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@article{1763423,
author = {Halámková, Jana and Kazda, Tomáš and Pehalová, Lucie and Goněc, Roman and Kozáková, Šárka and Bohovicová, Lucia and Krakorova Adamkova, Dagmar and Slabý, Ondřej and Demlová, Regina and Svoboda, Marek and Kiss, Igor},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-021-82248-7},
keywords = {colorectal cancer; second primary malignancies},
language = {eng},
issn = {2045-2322},
journal = {Nature Scientific Reports},
title = {Second primary malignancies in colorectal cancer patients},
url = {https://www.nature.com/articles/s41598-021-82248-7.pdf},
volume = {11},
year = {2021}
}
TY - JOUR
ID - 1763423
AU - Halámková, Jana - Kazda, Tomáš - Pehalová, Lucie - Goněc, Roman - Kozáková, Šárka - Bohovicová, Lucia - Krakorova Adamkova, Dagmar - Slabý, Ondřej - Demlová, Regina - Svoboda, Marek - Kiss, Igor
PY - 2021
TI - Second primary malignancies in colorectal cancer patients
JF - Nature Scientific Reports
VL - 11
IS - 1
SP - 1-12
EP - 1-12
PB - NATURE RESEARCH
SN - 20452322
KW - colorectal cancer
KW - second primary malignancies
UR - https://www.nature.com/articles/s41598-021-82248-7.pdf
N2 - The prevalence of second primary malignancies (SPMs) in the western world is continually increasing with the risk of a new primary cancer in patients with previously diagnosed carcinoma at about 20%. The aim of this retrospective analysis is to identify SPMs in colorectal cancer patients in a single-institution cohort, describe the most frequent SPMs in colorectal cancer patients, and discover the time period to occurrence of second primary tumors. We identified 1174 patients diagnosed with colorectal cancer in the period 2003-2013, with follow-up till 31.12.2018, and median follow-up of 10.1 years, (median age 63 years, 724 men). A second primary neoplasm was diagnosed in 234 patients (19.9%). Older age patients, those with early-stage disease and those with no relapse have a higher risk of secondary cancer development. The median time from cancer diagnosis to development of CRC was 8.9 years for breast cancer and 3.4 years for prostate cancer. For the most common cancer diagnosis after primary CRC, the median time to development was 0-5.2 years, depending on the type of malignancy. Patients with a diagnosis of breast, prostate, or kidney cancer, or melanoma should be regularly screened for CRC. CRC patients should also be screened for additional CRC as well as cancers of the breast, prostate, kidney, and bladder. The screening of cancer patients for the most frequent malignancies along with systematic patient education in this field should be the standard of surveillance for colorectal cancer patients.
ER -
HALÁMKOVÁ, Jana, Tomáš KAZDA, Lucie PEHALOVÁ, Roman GONĚC, Šárka KOZÁKOVÁ, Lucia BOHOVICOVÁ, Dagmar KRAKOROVA ADAMKOVA, Ondřej SLABÝ, Regina DEMLOVÁ, Marek SVOBODA and Igor KISS. Second primary malignancies in colorectal cancer patients. \textit{Nature Scientific Reports}. London: NATURE RESEARCH, 2021, vol.~11, No~1, p.~1-12. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-021-82248-7.
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