RICHTER, J., A. LUBKING, S. SODERLUND, K. LOTFI, B. MARKEVARN, A. SJALANDER, L. STENKE, S. DENEBERG, E. AHLSTRAND, K. MYHR-ERIKSSON, P. PANAYIOTIDIS, T. GEDDE-DAHL, Daniela ŽÁČKOVÁ, Jiří MAYER, U. OLSSON-STROMBERG, F. X. MAHON, S. SAUSSELE, H. HJORTH-HANSEN and P. KOSKENVESA. Molecular status 36 months after TKI discontinuation in CML is highly predictive for subsequent loss of MMR-final report from AFTER-SKI. Leukemia. London: Nature Publishing Group, 2021, vol. 35, No 8, p. 2416-2418. ISSN 0887-6924. Available from: https://dx.doi.org/10.1038/s41375-021-01173-w.
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Basic information
Original name Molecular status 36 months after TKI discontinuation in CML is highly predictive for subsequent loss of MMR-final report from AFTER-SKI
Authors RICHTER, J. (guarantor), A. LUBKING, S. SODERLUND, K. LOTFI, B. MARKEVARN, A. SJALANDER, L. STENKE, S. DENEBERG, E. AHLSTRAND, K. MYHR-ERIKSSON, P. PANAYIOTIDIS, T. GEDDE-DAHL, Daniela ŽÁČKOVÁ (203 Czech Republic, belonging to the institution), Jiří MAYER (203 Czech Republic, belonging to the institution), U. OLSSON-STROMBERG, F. X. MAHON, S. SAUSSELE, H. HJORTH-HANSEN and P. KOSKENVESA.
Edition Leukemia, London, Nature Publishing Group, 2021, 0887-6924.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30205 Hematology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 12.883
RIV identification code RIV/00216224:14110/21:00121497
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1038/s41375-021-01173-w
UT WoS 000618175800004
Keywords in English TKI discontinuation; CML; MMR-final report; AFTER-SKI
Tags 14110212, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 21/10/2021 10:00.
Abstract
Discontinuation of tyrosine kinase inhibitor (TKI) treatment for chronic phase (CP) CML patients with a deep molecular response (DMR) has entered standard practice. This is based on numerous clinical studies showing that ~50% of patients with DMR can stop TKI treatment without imminent disease relapse. However, in most of these trials long-term follow-up has been limited.
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