Pattern of Relapse and Treatment Response in WNT-Activated
Medulloblastoma

J 2020

Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma

NOBRE, L., M. ZAPOTOCKY, S. KHAN, K. FUKUOKA, A. FONSECA et. al.

Basic information

Original name

Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma

Authors

NOBRE, L., M. ZAPOTOCKY, S. KHAN, K. FUKUOKA, A. FONSECA, T. MCKEOWN, D. SUMERAUER, A. VICHA, W. A. GRAJKOWSKA, J. TRUBICKA, K. K. W. LI, H. K. NG, L. MASSIMI, J. Y. LEE, S. K. KIM, S. ZELCER, A. VASILJEVIC, C. FAURE-CONTER, P. HAUSER, B. LACH, M. L. VAN VEELEN-VINCENT, PJ FRENCH, Meir EG VAN, W. A. WEISS, N. GUPTA, I. F. POLLACK, R. L. HAMILTON, A. A. N. RAO, C. GIANNINI, J. B. RUBIN, A. S. MOORE, L. B. CHAMBLESS, R. VIBHAKAR, Y. S. RA, M. MASSIMINO, R. E. MCLENDON, H. WHEELER, M. ZOLLO, V. FERRUCI, T. KUMABE, C. C. FARIA, Jaroslav ŠTĚRBA (203 Czech Republic, belonging to the institution), S. JUNG, E. LOPEZ-AGUILAR, J. MORA, C. G. CARLOTTI, J. M. OLSON, S. LEARY, J. CAIN, L. KRSKOVA, J. ZAMECNIK, C. E. HAWKINS, U. TABORI, A. N. HUANG, U. BARTELS, P. A. NORTHCOTT, M. D. TAYLOR, S. YIP, J. R. HANSFORD, E. BOUFFET and V. RAMASWAMY (guarantor)

Edition

CELL REPORTS MEDICINE, AMSTERDAM, ELSEVIER, 2020, 2666-3791

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14110/20:00118572

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.xcrm.2020.100038

UT WoS

000642296600006

Keywords in English

WNT-Activated Medulloblastoma

Abstract

V originále

Over the past decade, wingless-activated (WNT) medulloblastoma has been identified as a candidate for therapy de-escalation based on excellent survival; however, a paucity of relapses has precluded additional analyses of markers of relapse. To address this gap in knowledge, an international cohort of 93 molecularly confirmed WNT MB was assembled, where 5-year progression-free survival is 0.84 (95%, 0.763-0.925) with 15 relapsed individuals identified. Maintenance chemotherapy is identified as a strong predictor of relapse, with individuals receiving high doses of cyclophosphamide or ifosphamide having only one very late molecularly confirmed relapse (p = 0.032). The anatomical location of recurrence is metastatic in 12 of 15 relapses, with 8 of 12 metastatic relapses in the lateral ventricles. Maintenance chemotherapy, specifically cumulative cyclophosphamide doses, is a significant predictor of relapse across WNT MB. Future efforts to de-escalate therapy need to carefully consider not only the radiation dose but also the chemotherapy regimen and the propensity for metastatic relapses.

Citovat

NOBRE, L., M. ZAPOTOCKY, S. KHAN, K. FUKUOKA, A. FONSECA, T. MCKEOWN, D. SUMERAUER, A. VICHA, W. A. GRAJKOWSKA, J. TRUBICKA, K. K. W. LI, H. K. NG, L. MASSIMI, J. Y. LEE, S. K. KIM, S. ZELCER, A. VASILJEVIC, C. FAURE-CONTER, P. HAUSER, B. LACH, M. L. VAN VEELEN-VINCENT, PJ FRENCH, Meir EG VAN, W. A. WEISS, N. GUPTA, I. F. POLLACK, R. L. HAMILTON, A. A. N. RAO, C. GIANNINI, J. B. RUBIN, A. S. MOORE, L. B. CHAMBLESS, R. VIBHAKAR, Y. S. RA, M. MASSIMINO, R. E. MCLENDON, H. WHEELER, M. ZOLLO, V. FERRUCI, T. KUMABE, C. C. FARIA, Jaroslav ŠTĚRBA, S. JUNG, E. LOPEZ-AGUILAR, J. MORA, C. G. CARLOTTI, J. M. OLSON, S. LEARY, J. CAIN, L. KRSKOVA, J. ZAMECNIK, C. E. HAWKINS, U. TABORI, A. N. HUANG, U. BARTELS, P. A. NORTHCOTT, M. D. TAYLOR, S. YIP, J. R. HANSFORD, E. BOUFFET and V. RAMASWAMY. Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma. CELL REPORTS MEDICINE. AMSTERDAM: ELSEVIER, 2020, vol. 1, No 3, p. 1-11. ISSN 2666-3791. Available from: https://dx.doi.org/10.1016/j.xcrm.2020.100038.

@article{1766037,
   author = {Nobre, L. and Zapotocky, M. and Khan, S. and Fukuoka, K. and Fonseca, A. and McKeown, T. and Sumerauer, D. and Vicha, A. and Grajkowska, W. A. and Trubicka, J. and Li, K. K. W. and Ng, H. K. and Massimi, L. and Lee, J. Y. and Kim, S. K. and Zelcer, S. and Vasiljevic, A. and FaureandConter, C. and Hauser, P. and Lach, B. and Van VeelenandVincent, M. L. and French, PJ and Van, Meir EG and Weiss, W. A. and Gupta, N. and Pollack, I. F. and Hamilton, R. L. and Rao, A. A. N. and Giannini, C. and Rubin, J. B. and Moore, A. S. and Chambless, L. B. and Vibhakar, R. and Ra, Y. S. and Massimino, M. and McLendon, R. E. and Wheeler, H. and Zollo, M. and Ferruci, V. and Kumabe, T. and Faria, C. C. and Štěrba, Jaroslav and Jung, S. and LopezandAguilar, E. and Mora, J. and Carlotti, C. G. and Olson, J. M. and Leary, S. and Cain, J. and Krskova, L. and Zamecnik, J. and Hawkins, C. E. and Tabori, U. and Huang, A. N. and Bartels, U. and Northcott, P. A. and Taylor, M. D. and Yip, S. and Hansford, J. R. and Bouffet, E. and Ramaswamy, V.},
   article_location = {AMSTERDAM},
   article_number = {3},
   doi = {http://dx.doi.org/10.1016/j.xcrm.2020.100038},
   keywords = {WNT-Activated Medulloblastoma},
   language = {eng},
   issn = {2666-3791},
   journal = {CELL REPORTS MEDICINE},
   title = {Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma},
   url = {https://www.cell.com/cell-reports-medicine/pdf/S2666-3791(20)30050-1.pdf},
   volume = {1},
   year = {2020}
}

TY  - JOUR
ID  - 1766037
AU  - Nobre, L. - Zapotocky, M. - Khan, S. - Fukuoka, K. - Fonseca, A. - McKeown, T. - Sumerauer, D. - Vicha, A. - Grajkowska, W. A. - Trubicka, J. - Li, K. K. W. - Ng, H. K. - Massimi, L. - Lee, J. Y. - Kim, S. K. - Zelcer, S. - Vasiljevic, A. - Faure-Conter, C. - Hauser, P. - Lach, B. - Van Veelen-Vincent, M. L. - French, PJ - Van, Meir EG - Weiss, W. A. - Gupta, N. - Pollack, I. F. - Hamilton, R. L. - Rao, A. A. N. - Giannini, C. - Rubin, J. B. - Moore, A. S. - Chambless, L. B. - Vibhakar, R. - Ra, Y. S. - Massimino, M. - McLendon, R. E. - Wheeler, H. - Zollo, M. - Ferruci, V. - Kumabe, T. - Faria, C. C. - Štěrba, Jaroslav - Jung, S. - Lopez-Aguilar, E. - Mora, J. - Carlotti, C. G. - Olson, J. M. - Leary, S. - Cain, J. - Krskova, L. - Zamecnik, J. - Hawkins, C. E. - Tabori, U. - Huang, A. N. - Bartels, U. - Northcott, P. A. - Taylor, M. D. - Yip, S. - Hansford, J. R. - Bouffet, E. - Ramaswamy, V.
PY  - 2020
TI  - Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma
JF  - CELL REPORTS MEDICINE
VL  - 1
IS  - 3
SP  - 1-11
EP  - 1-11
PB  - ELSEVIER
SN  - 26663791
KW  - WNT-Activated Medulloblastoma
UR  - https://www.cell.com/cell-reports-medicine/pdf/S2666-3791(20)30050-1.pdf
N2  - Over the past decade, wingless-activated (WNT) medulloblastoma has been identified as a candidate for therapy de-escalation based on excellent survival; however, a paucity of relapses has precluded additional analyses of markers of relapse. To address this gap in knowledge, an international cohort of 93 molecularly confirmed WNT MB was assembled, where 5-year progression-free survival is 0.84 (95%, 0.763-0.925) with 15 relapsed individuals identified. Maintenance chemotherapy is identified as a strong predictor of relapse, with individuals receiving high doses of cyclophosphamide or ifosphamide having only one very late molecularly confirmed relapse (p = 0.032). The anatomical location of recurrence is metastatic in 12 of 15 relapses, with 8 of 12 metastatic relapses in the lateral ventricles. Maintenance chemotherapy, specifically cumulative cyclophosphamide doses, is a significant predictor of relapse across WNT MB. Future efforts to de-escalate therapy need to carefully consider not only the radiation dose but also the chemotherapy regimen and the propensity for metastatic relapses.
ER  -

NOBRE, L., M. ZAPOTOCKY, S. KHAN, K. FUKUOKA, A. FONSECA, T. MCKEOWN, D. SUMERAUER, A. VICHA, W. A. GRAJKOWSKA, J. TRUBICKA, K. K. W. LI, H. K. NG, L. MASSIMI, J. Y. LEE, S. K. KIM, S. ZELCER, A. VASILJEVIC, C. FAURE-CONTER, P. HAUSER, B. LACH, M. L. VAN VEELEN-VINCENT, PJ FRENCH, Meir EG VAN, W. A. WEISS, N. GUPTA, I. F. POLLACK, R. L. HAMILTON, A. A. N. RAO, C. GIANNINI, J. B. RUBIN, A. S. MOORE, L. B. CHAMBLESS, R. VIBHAKAR, Y. S. RA, M. MASSIMINO, R. E. MCLENDON, H. WHEELER, M. ZOLLO, V. FERRUCI, T. KUMABE, C. C. FARIA, Jaroslav ŠTĚRBA, S. JUNG, E. LOPEZ-AGUILAR, J. MORA, C. G. CARLOTTI, J. M. OLSON, S. LEARY, J. CAIN, L. KRSKOVA, J. ZAMECNIK, C. E. HAWKINS, U. TABORI, A. N. HUANG, U. BARTELS, P. A. NORTHCOTT, M. D. TAYLOR, S. YIP, J. R. HANSFORD, E. BOUFFET and V. RAMASWAMY. Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma. \textit{CELL REPORTS MEDICINE}. AMSTERDAM: ELSEVIER, 2020, vol.~1, No~3, p.~1-11. ISSN~2666-3791. Available from: https://dx.doi.org/10.1016/j.xcrm.2020.100038.

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