MARGIOTTA, Azzurra. Role of SNAREs in Neurodegenerative Diseases. Cells. Basel: MDPI, 2021, vol. 10, No 5, p. 1-15. ISSN 2073-4409. Available from: https://dx.doi.org/10.3390/cells10050991.
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Basic information
Original name Role of SNAREs in Neurodegenerative Diseases
Authors MARGIOTTA, Azzurra (380 Italy, guarantor, belonging to the institution).
Edition Cells, Basel, MDPI, 2021, 2073-4409.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10601 Cell biology
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 7.666
RIV identification code RIV/00216224:14110/21:00121544
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.3390/cells10050991
UT WoS 000654677300001
Keywords in English SNAREs; neurodegenerative disease; ALS; Parkinson disease; Alzheimer disease; VAMP2; syn1; SNAP-25
Tags 14110513, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 3/6/2021 13:32.
Abstract
Neurodegenerative diseases are pathologies of the central and peripheral nervous systems characterized by loss of brain functions and problems in movement which occur due to the slow and progressive degeneration of cellular elements. Several neurodegenerative diseases are known such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and many studies on the molecular mechanisms underlying these pathologies have been conducted. Altered functions of some key proteins and the presence of intraneuronal aggregates have been identified as responsible for the development of the diseases. Interestingly, the formation of the SNARE complex has been discovered to be fundamental for vesicle fusion, vesicle recycling and neurotransmitter release. Indeed, inhibition of the formation of the SNARE complex, defects in the SNARE-dependent exocytosis and altered regulation of SNARE-mediated vesicle fusion have been associated with neurodegeneration. In this review, the biological aspects of neurodegenerative diseases and the role of SNARE proteins in relation to the onset of these pathologies are described.
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