Role of SNAREs in Neurodegenerative Diseases

J 2021

Role of SNAREs in Neurodegenerative Diseases

MARGIOTTA, Azzurra

Basic information

Original name

Role of SNAREs in Neurodegenerative Diseases

Authors

MARGIOTTA, Azzurra (380 Italy, guarantor, belonging to the institution)

Edition

Cells, Basel, MDPI, 2021, 2073-4409

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.666

RIV identification code

RIV/00216224:14110/21:00121544

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/cells10050991

UT WoS

000654677300001

Keywords in English

SNAREs; neurodegenerative disease; ALS; Parkinson disease; Alzheimer disease; VAMP2; syn1; SNAP-25

Abstract

V originále

Neurodegenerative diseases are pathologies of the central and peripheral nervous systems characterized by loss of brain functions and problems in movement which occur due to the slow and progressive degeneration of cellular elements. Several neurodegenerative diseases are known such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and many studies on the molecular mechanisms underlying these pathologies have been conducted. Altered functions of some key proteins and the presence of intraneuronal aggregates have been identified as responsible for the development of the diseases. Interestingly, the formation of the SNARE complex has been discovered to be fundamental for vesicle fusion, vesicle recycling and neurotransmitter release. Indeed, inhibition of the formation of the SNARE complex, defects in the SNARE-dependent exocytosis and altered regulation of SNARE-mediated vesicle fusion have been associated with neurodegeneration. In this review, the biological aspects of neurodegenerative diseases and the role of SNARE proteins in relation to the onset of these pathologies are described.

Citovat

MARGIOTTA, Azzurra. Role of SNAREs in Neurodegenerative Diseases. Cells. Basel: MDPI, 2021, vol. 10, No 5, p. 1-15. ISSN 2073-4409. Available from: https://dx.doi.org/10.3390/cells10050991.

@article{1766117,
   author = {Margiotta, Azzurra},
   article_location = {Basel},
   article_number = {5},
   doi = {http://dx.doi.org/10.3390/cells10050991},
   keywords = {SNAREs; neurodegenerative disease; ALS; Parkinson disease; Alzheimer disease; VAMP2; syn1; SNAP-25},
   language = {eng},
   issn = {2073-4409},
   journal = {Cells},
   title = {Role of SNAREs in Neurodegenerative Diseases},
   url = {https://www.mdpi.com/2073-4409/10/5/991},
   volume = {10},
   year = {2021}
}

TY  - JOUR
ID  - 1766117
AU  - Margiotta, Azzurra
PY  - 2021
TI  - Role of SNAREs in Neurodegenerative Diseases
JF  - Cells
VL  - 10
IS  - 5
SP  - 1-15
EP  - 1-15
PB  - MDPI
SN  - 20734409
KW  - SNAREs
KW  - neurodegenerative disease
KW  - ALS
KW  - Parkinson disease
KW  - Alzheimer disease
KW  - VAMP2
KW  - syn1
KW  - SNAP-25
UR  - https://www.mdpi.com/2073-4409/10/5/991
N2  - Neurodegenerative diseases are pathologies of the central and peripheral nervous systems characterized by loss of brain functions and problems in movement which occur due to the slow and progressive degeneration of cellular elements. Several neurodegenerative diseases are known such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and many studies on the molecular mechanisms underlying these pathologies have been conducted. Altered functions of some key proteins and the presence of intraneuronal aggregates have been identified as responsible for the development of the diseases. Interestingly, the formation of the SNARE complex has been discovered to be fundamental for vesicle fusion, vesicle recycling and neurotransmitter release. Indeed, inhibition of the formation of the SNARE complex, defects in the SNARE-dependent exocytosis and altered regulation of SNARE-mediated vesicle fusion have been associated with neurodegeneration. In this review, the biological aspects of neurodegenerative diseases and the role of SNARE proteins in relation to the onset of these pathologies are described.
ER  -

MARGIOTTA, Azzurra. Role of SNAREs in Neurodegenerative Diseases. \textit{Cells}. Basel: MDPI, 2021, vol.~10, No~5, p.~1-15. ISSN~2073-4409. Available from: https://dx.doi.org/10.3390/cells10050991.

Detailed Information on Publication Record