PREVIS: Predictive visual analytics of anatomical variability for radiotherapy decision support

FURMANOVÁ, Katarína, Ludvig P MUREN, Oscar CASARES-MAGAZ, Vitali MOISEENKO, John P EINCK, Sara PILSKOG and Renata G RAIDOU. PREVIS: Predictive visual analytics of anatomical variability for radiotherapy decision support. Computers & Graphics. Elsevier Science, 2021, vol. 97, April, p. 126-138. ISSN 0097-8493. Available from: https://dx.doi.org/10.1016/j.cag.2021.04.010.

Basic information

Original name

PREVIS: Predictive visual analytics of anatomical variability for radiotherapy decision support

Authors

FURMANOVÁ, Katarína (703 Slovakia, belonging to the institution), Ludvig P MUREN, Oscar CASARES-MAGAZ, Vitali MOISEENKO, John P EINCK, Sara PILSKOG and Renata G RAIDOU

Edition

Computers & Graphics, Elsevier Science, 2021, 0097-8493

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10200 1.2 Computer and information sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.821

RIV identification code

RIV/00216224:14330/21:00124927

Organization unit

Faculty of Informatics

DOI

http://dx.doi.org/10.1016/j.cag.2021.04.010

UT WoS

000661427000001

Keywords in English

Medical Visualization; Visual Analytics; Comparative Visualization; Ensemble Visualization; Radiotherapy Planning; Cohort Study

Tags

International impact, Reviewed

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Abstract

V originále

Radiotherapy (RT) requires meticulous planning prior to treatment, where the RT plan is optimized with organ delineations on a pre-treatment Computed Tomography (CT) scan of the patient. The conventionally fractionated treatment usually lasts several weeks. Random changes (e.g., rectal and bladder filling in prostate cancer patients) and systematic changes (e.g., weight loss) occur while the patient is being treated. Therefore, the delivered dose distribution may deviate from the planned. Modern technology, in particular image guidance, allows to minimize these deviations, but risks for the patient remain. We present PREVIS: a visual analytics tool for (i) the exploration and prediction of changes in patient anatomy during the upcoming treatment, and (ii) the assessment of treatment strategies, with respect to the anticipated changes. Records of during-treatment changes from a retrospective imaging cohort with complete data are employed in PREVIS, to infer expected anatomical changes of new incoming patients with incomplete data, using a generative model. Abstracted representations of the retrospective cohort partitioning provide insight into an underlying automated clustering, showing main modes of variation for past patients. Interactive similarity representations support an informed selection of matching between new incoming patients and past patients. A Principal Component Analysis (PCA)-based generative model describes the predicted spatial probability distributions of the incoming patient’s organs in the upcoming weeks of treatment, based on observations of past patients. The generative model is interactively linked to treatment plan evaluation, supporting the selection of the optimal treatment strategy. We present a usage scenario, demonstrating the applicability of PREVIS in a clinical research setting, and we evaluate our visual analytics tool with eight clinical researchers.