Impact of Antibiotics Associated with the Development of Toxic
Epidermal Necrolysis on Early and Late-Onset Infectious
Complications

J 2021

Impact of Antibiotics Associated with the Development of Toxic Epidermal Necrolysis on Early and Late-Onset Infectious Complications

LIPOVÝ, Břetislav, Jakub HOLOUBEK, Marketa HANSLIANOVA, Michaela CVANOVÁ, Leo KLEIN et. al.

Basic information

Original name

Impact of Antibiotics Associated with the Development of Toxic Epidermal Necrolysis on Early and Late-Onset Infectious Complications

Authors

LIPOVÝ, Břetislav (203 Czech Republic, belonging to the institution), Jakub HOLOUBEK (203 Czech Republic, belonging to the institution), Marketa HANSLIANOVA (203 Czech Republic), Michaela CVANOVÁ (203 Czech Republic, belonging to the institution), Leo KLEIN (203 Czech Republic), Ivana GROSSOVA (203 Czech Republic), Robert ZAJICEK, Peter BUKOVCAN (703 Slovakia), Jan KOLLER (703 Slovakia), Matus BARAN (703 Slovakia), Peter LENGYEL (703 Slovakia), Lukas EIMER (203 Czech Republic), Marie JANDOVA (203 Czech Republic), Milan KOSTAL (203 Czech Republic), Pavel BRYCHTA (203 Czech Republic, belonging to the institution) and Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution)

Edition

Microorganisms, Basel, MDPI, 2021, 2076-2607

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10606 Microbiology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.926

RIV identification code

RIV/00216224:14110/21:00121573

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/microorganisms9010202

UT WoS

000610585100001

Keywords in English

toxic epidermal necrolysis; antibiotics; infectious complication; early-onset infection; late-onset infection

Abstract

V originále

Toxic epidermal necrolysis (TEN) is a rare disease, which predominantly manifests as damage to the skin and mucosa. Antibiotics count among the most common triggers of this hypersensitive reaction. Patients with TEN are highly susceptible to infectious complications due to the loss of protective barriers and immunosuppressant therapy. The aim of this study was to investigate the potential relationship between antibiotics used before the development of TEN and early and late-onset infectious complications in TEN patients. In this European multicentric retrospective study (Central European Lyell syndrome: therapeutic evaluation (CELESTE)), records showed that 18 patients with TEN used antibiotics (mostly aminopenicillins) before the disease development (group 1), while in 21 patients, TEN was triggered by another factor (group 2). The incidence of late-onset infectious complications (5 or more days after the transfer to the hospital) caused by Gram-positive bacteria (especially by Enterococcus faecalis/faecium) was significantly higher in group 1 than in group 2 (82.4% vs. 35.0%, p = 0.007/p(corr) = 0.014) while no statistically significant difference was observed between groups of patients with infection caused by Gram-negative bacteria, yeasts, and filamentous fungi (p > 0.05). Patients with post-antibiotic development of TEN are critically predisposed to late-onset infectious complications caused by Gram-positive bacteria, which may result from the dissemination of these bacteria from the primary focus.

Links

ROZV/28/LF5/2020, interní kód MU

Name: Molekulárně genetické a mikrobiologické analýzy u pacientů s termálně a netermálně indukovanou ztrátou kožního krytu

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

LIPOVÝ, Břetislav, Jakub HOLOUBEK, Marketa HANSLIANOVA, Michaela CVANOVÁ, Leo KLEIN, Ivana GROSSOVA, Robert ZAJICEK, Peter BUKOVCAN, Jan KOLLER, Matus BARAN, Peter LENGYEL, Lukas EIMER, Marie JANDOVA, Milan KOSTAL, Pavel BRYCHTA and Petra BOŘILOVÁ LINHARTOVÁ. Impact of Antibiotics Associated with the Development of Toxic Epidermal Necrolysis on Early and Late-Onset Infectious Complications. Microorganisms. Basel: MDPI, 2021, vol. 9, No 1, p. 1-15. ISSN 2076-2607. Available from: https://dx.doi.org/10.3390/microorganisms9010202.

@article{1767998,
   author = {Lipový, Břetislav and Holoubek, Jakub and Hanslianova, Marketa and Cvanová, Michaela and Klein, Leo and Grossova, Ivana and Zajicek, Robert and Bukovcan, Peter and Koller, Jan and Baran, Matus and Lengyel, Peter and Eimer, Lukas and Jandova, Marie and Kostal, Milan and Brychta, Pavel and Bořilová Linhartová, Petra},
   article_location = {Basel},
   article_number = {1},
   doi = {http://dx.doi.org/10.3390/microorganisms9010202},
   keywords = {toxic epidermal necrolysis; antibiotics; infectious complication; early-onset infection; late-onset infection},
   language = {eng},
   issn = {2076-2607},
   journal = {Microorganisms},
   title = {Impact of Antibiotics Associated with the Development of Toxic Epidermal Necrolysis on Early and Late-Onset Infectious Complications},
   url = {https://www.mdpi.com/2076-2607/9/1/202},
   volume = {9},
   year = {2021}
}

TY  - JOUR
ID  - 1767998
AU  - Lipový, Břetislav - Holoubek, Jakub - Hanslianova, Marketa - Cvanová, Michaela - Klein, Leo - Grossova, Ivana - Zajicek, Robert - Bukovcan, Peter - Koller, Jan - Baran, Matus - Lengyel, Peter - Eimer, Lukas - Jandova, Marie - Kostal, Milan - Brychta, Pavel - Bořilová Linhartová, Petra
PY  - 2021
TI  - Impact of Antibiotics Associated with the Development of Toxic Epidermal Necrolysis on Early and Late-Onset Infectious Complications
JF  - Microorganisms
VL  - 9
IS  - 1
SP  - 1-15
EP  - 1-15
PB  - MDPI
SN  - 20762607
KW  - toxic epidermal necrolysis
KW  - antibiotics
KW  - infectious complication
KW  - early-onset infection
KW  - late-onset infection
UR  - https://www.mdpi.com/2076-2607/9/1/202
N2  - Toxic epidermal necrolysis (TEN) is a rare disease, which predominantly manifests as damage to the skin and mucosa. Antibiotics count among the most common triggers of this hypersensitive reaction. Patients with TEN are highly susceptible to infectious complications due to the loss of protective barriers and immunosuppressant therapy. The aim of this study was to investigate the potential relationship between antibiotics used before the development of TEN and early and late-onset infectious complications in TEN patients. In this European multicentric retrospective study (Central European Lyell syndrome: therapeutic evaluation (CELESTE)), records showed that 18 patients with TEN used antibiotics (mostly aminopenicillins) before the disease development (group 1), while in 21 patients, TEN was triggered by another factor (group 2). The incidence of late-onset infectious complications (5 or more days after the transfer to the hospital) caused by Gram-positive bacteria (especially by Enterococcus faecalis/faecium) was significantly higher in group 1 than in group 2 (82.4% vs. 35.0%, p = 0.007/p(corr) = 0.014) while no statistically significant difference was observed between groups of patients with infection caused by Gram-negative bacteria, yeasts, and filamentous fungi (p > 0.05). Patients with post-antibiotic development of TEN are critically predisposed to late-onset infectious complications caused by Gram-positive bacteria, which may result from the dissemination of these bacteria from the primary focus.
ER  -

LIPOVÝ, Břetislav, Jakub HOLOUBEK, Marketa HANSLIANOVA, Michaela CVANOVÁ, Leo KLEIN, Ivana GROSSOVA, Robert ZAJICEK, Peter BUKOVCAN, Jan KOLLER, Matus BARAN, Peter LENGYEL, Lukas EIMER, Marie JANDOVA, Milan KOSTAL, Pavel BRYCHTA and Petra BOŘILOVÁ LINHARTOVÁ. Impact of Antibiotics Associated with the Development of Toxic Epidermal Necrolysis on Early and Late-Onset Infectious Complications. \textit{Microorganisms}. Basel: MDPI, 2021, vol.~9, No~1, p.~1-15. ISSN~2076-2607. Available from: https://dx.doi.org/10.3390/microorganisms9010202.

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