On the Role of Bilateral Brain Hypofunction and Abnormal
Lateralization of Cortical Information Flow as Neural
Underpinnings of Conventional Metaphor Processing Impairment in
Schizophrenia: An fMRI and EEG Study

J 2021

On the Role of Bilateral Brain Hypofunction and Abnormal Lateralization of Cortical Information Flow as Neural Underpinnings of Conventional Metaphor Processing Impairment in Schizophrenia: An fMRI and EEG Study

ADAMCZYK, Przemysław, Martin JÁNI, Tomasz S. LIGEZA, Olga PŁONKA, Piotr BŁĄDZIŃSKI et. al.

Basic information

Original name

On the Role of Bilateral Brain Hypofunction and Abnormal Lateralization of Cortical Information Flow as Neural Underpinnings of Conventional Metaphor Processing Impairment in Schizophrenia: An fMRI and EEG Study

Authors

ADAMCZYK, Przemysław (guarantor), Martin JÁNI (703 Slovakia, belonging to the institution), Tomasz S. LIGEZA, Olga PŁONKA, Piotr BŁĄDZIŃSKI and Miroslaw WYCZESANY

Edition

Brain Topography, Dordrecht, Springer, 2021, 0896-0267

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.275

RIV identification code

RIV/00216224:14110/21:00121599

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s10548-021-00849-x

UT WoS

000648852000002

Keywords in English

Metaphor; Schizophrenia; Effective connectivity; Lateralization; Electroencephalography; Directed transfer function; Functional magnetic resonance imaging

Abstract

V originále

Figurative language processing (e.g. metaphors) is commonly impaired in schizophrenia. In the present study, we investigated the neural activity and propagation of information within neural circuits related to the figurative speech, as a neural substrate of impaired conventional metaphor processing in schizophrenia. The study included 30 schizophrenia outpatients and 30 healthy controls, all of whom were assessed with a functional Magnetic Resonance Imaging (fMRI) and electroencephalography (EEG) punchline-based metaphor comprehension task including literal (neutral), figurative (metaphorical) and nonsense (absurd) endings. The blood oxygenation level-dependent signal was recorded with 3T MRI scanner and direction and strength of cortical information flow in the time course of task processing was estimated with a 64-channel EEG input for directed transfer function. The presented results revealed that the behavioral manifestation of impaired figurative language in schizophrenia is related to the hypofunction in the bilateral fronto-temporo-parietal brain regions (fMRI) and various differences in effective connectivity in the fronto-temporo-parietal circuit (EEG). Schizophrenia outpatients showed an abnormal pattern of connectivity during metaphor processing which was related to bilateral (but more pronounced at the left hemisphere) hypoactivation of the brain. Moreover, we found reversed lateralization patterns, i.e. a rightward-shifted pattern during metaphor processing in schizophrenia compared to the control group. In conclusion, the presented findings revealed that the impairment of the conventional metaphor processing in schizophrenia is related to the bilateral brain hypofunction, which supports the evidence on reversed lateralization of the language neural network and the existence of compensatory recruitment of alternative neural circuits in schizophrenia.

Citovat

ADAMCZYK, Przemysław, Martin JÁNI, Tomasz S. LIGEZA, Olga PŁONKA, Piotr BŁĄDZIŃSKI and Miroslaw WYCZESANY. On the Role of Bilateral Brain Hypofunction and Abnormal Lateralization of Cortical Information Flow as Neural Underpinnings of Conventional Metaphor Processing Impairment in Schizophrenia: An fMRI and EEG Study. Brain Topography. Dordrecht: Springer, 2021, vol. 34, No 4, p. 537-554. ISSN 0896-0267. Available from: https://dx.doi.org/10.1007/s10548-021-00849-x.

@article{1769297,
   author = {Adamczyk, Przemysław and Jáni, Martin and Ligeza, Tomasz S. and Płonka, Olga and Błądziński, Piotr and Wyczesany, Miroslaw},
   article_location = {Dordrecht},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s10548-021-00849-x},
   keywords = {Metaphor; Schizophrenia; Effective connectivity; Lateralization; Electroencephalography; Directed transfer function; Functional magnetic resonance imaging},
   language = {eng},
   issn = {0896-0267},
   journal = {Brain Topography},
   title = {On the Role of Bilateral Brain Hypofunction and Abnormal Lateralization of Cortical Information Flow as Neural Underpinnings of Conventional Metaphor Processing Impairment in Schizophrenia: An fMRI and EEG Study},
   url = {https://link.springer.com/article/10.1007%2Fs10548-021-00849-x},
   volume = {34},
   year = {2021}
}

TY  - JOUR
ID  - 1769297
AU  - Adamczyk, Przemysław - Jáni, Martin - Ligeza, Tomasz S. - Płonka, Olga - Błądziński, Piotr - Wyczesany, Miroslaw
PY  - 2021
TI  - On the Role of Bilateral Brain Hypofunction and Abnormal Lateralization of Cortical Information Flow as Neural Underpinnings of Conventional Metaphor Processing Impairment in Schizophrenia: An fMRI and EEG Study
JF  - Brain Topography
VL  - 34
IS  - 4
SP  - 537-554
EP  - 537-554
PB  - Springer
SN  - 08960267
KW  - Metaphor
KW  - Schizophrenia
KW  - Effective connectivity
KW  - Lateralization
KW  - Electroencephalography
KW  - Directed transfer function
KW  - Functional magnetic resonance imaging
UR  - https://link.springer.com/article/10.1007%2Fs10548-021-00849-x
N2  - Figurative language processing (e.g. metaphors) is commonly impaired in schizophrenia. In the present study, we investigated the neural activity and propagation of information within neural circuits related to the figurative speech, as a neural substrate of impaired conventional metaphor processing in schizophrenia. The study included 30 schizophrenia outpatients and 30 healthy controls, all of whom were assessed with a functional Magnetic Resonance Imaging (fMRI) and electroencephalography (EEG) punchline-based metaphor comprehension task including literal (neutral), figurative (metaphorical) and nonsense (absurd) endings. The blood oxygenation level-dependent signal was recorded with 3T MRI scanner and direction and strength of cortical information flow in the time course of task processing was estimated with a 64-channel EEG input for directed transfer function. The presented results revealed that the behavioral manifestation of impaired figurative language in schizophrenia is related to the hypofunction in the bilateral fronto-temporo-parietal brain regions (fMRI) and various differences in effective connectivity in the fronto-temporo-parietal circuit (EEG). Schizophrenia outpatients showed an abnormal pattern of connectivity during metaphor processing which was related to bilateral (but more pronounced at the left hemisphere) hypoactivation of the brain. Moreover, we found reversed lateralization patterns, i.e. a rightward-shifted pattern during metaphor processing in schizophrenia compared to the control group. In conclusion, the presented findings revealed that the impairment of the conventional metaphor processing in schizophrenia is related to the bilateral brain hypofunction, which supports the evidence on reversed lateralization of the language neural network and the existence of compensatory recruitment of alternative neural circuits in schizophrenia.
ER  -

ADAMCZYK, Przemysław, Martin JÁNI, Tomasz S. LIGEZA, Olga PŁONKA, Piotr BŁĄDZI$\backslash$'NSKI and Miroslaw WYCZESANY. On the Role of Bilateral Brain Hypofunction and Abnormal Lateralization of Cortical Information Flow as Neural Underpinnings of Conventional Metaphor Processing Impairment in Schizophrenia: An fMRI and EEG Study. \textit{Brain Topography}. Dordrecht: Springer, 2021, vol.~34, No~4, p.~537-554. ISSN~0896-0267. Available from: https://dx.doi.org/10.1007/s10548-021-00849-x.

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