J 2021

The neural substrates of diminished humor comprehension in schizophrenia and its relationship with psychopathology

JÁNI, Martin, Olga PŁONKA, Artur DAREN, Piotr BŁĄDZIŃSKI, Aneta KALISZ et. al.

Basic information

Original name

The neural substrates of diminished humor comprehension in schizophrenia and its relationship with psychopathology

Authors

JÁNI, Martin (703 Slovakia, guarantor, belonging to the institution), Olga PŁONKA, Artur DAREN, Piotr BŁĄDZIŃSKI, Aneta KALISZ, Mirosław WYCZESANY and Przemysław ADAMCZYK

Edition

Acta Neurobiologiae Experimentalis, Warsaw, NENCKI INST EXPERIMENTAL BIOLOGY, 2021, 0065-1400

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.269

RIV identification code

RIV/00216224:14110/21:00121600

Organization unit

Faculty of Medicine

DOI

UT WoS

000665479700007

Keywords in English

electroencephalography; neuroimaging; psychopathology; schizophrenia; figurative language

Tags

Tags

International impact, Reviewed
Změněno: 24/8/2021 10:36, Mgr. Tereza Miškechová

Abstract

V originále

Patients with schizophrenia commonly revealed difficulties in understanding humor. Previous research suggested links between impaired humor comprehension, psychopathology symptoms and cognitive deficits. In this study, we investigated the associations between neural substrates of humor processing and psychopathology and cognition in schizophrenia. We assessed 25 schizophrenia outpatients in an functional magnetic resonance imaging (fMRI) procedure and 40 in an electroencephalography (EEG) procedure. A punchline‑based humor comprehension task was used in which outpatients rated stories by their comprehensibility and funniness. The symptom severity and cognition were correlated with activation within the humor processing network using fMRI and effective connectivity using an EEG‑based directed transfer function (DTF) method. More severe positive and disorganization symptoms were associated with impaired humor comprehension and with altered temporo‑parietal effective connectivity during humor processing. More severe excitement and emotional reactivity symptoms were associated with increased activation in the bilateral frontal and temporo‑parietal regions. Moreover, schizophrenia outpatients with better cognitive functioning were more accurate in humor comprehension that was associated with increased fronto‑temporo‑parietal activation and effective connectivity. We found the intensity of humor processing (fMRI) in schizophrenia is related to the level of cognitive abilities and the severity of schizophrenia psychopathology that is also reflected in altered effective connectivity (EEG‑DTF) in the humor processing network.