| TICHA, Olga, Peter SLANINA, Lukas MOOS, Julie ŠTÍCHOVÁ, Marcela VLKOVÁ a Isabelle BEKEREDJIAN-DING. TNFR2 expression is a hallmark of human memory B cells with suppressive function. EUROPEAN JOURNAL OF IMMUNOLOGY. HOBOKEN: WILEY, 2021, roč. 51, č. 5, s. 1195-1205. ISSN 0014-2980. Dostupné z: https://dx.doi.org/10.1002/eji.202048988. |
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@article{1769698,
author = {Ticha, Olga and Slanina, Peter and Moos, Lukas and Štíchová, Julie and Vlková, Marcela and BekeredjianandDing, Isabelle},
article_location = {HOBOKEN},
article_number = {5},
doi = {http://dx.doi.org/10.1002/eji.202048988},
keywords = {B cells; Breg; IL‐ 10; TLR9; TNFR2},
language = {eng},
issn = {0014-2980},
journal = {EUROPEAN JOURNAL OF IMMUNOLOGY},
title = {TNFR2 expression is a hallmark of human memory B cells with suppressive function},
url = {https://onlinelibrary.wiley.com/journal/15214141},
volume = {51},
year = {2021}
}
TY - JOUR
ID - 1769698
AU - Ticha, Olga - Slanina, Peter - Moos, Lukas - Štíchová, Julie - Vlková, Marcela - Bekeredjian-Ding, Isabelle
PY - 2021
TI - TNFR2 expression is a hallmark of human memory B cells with suppressive function
JF - EUROPEAN JOURNAL OF IMMUNOLOGY
VL - 51
IS - 5
SP - 1195-1205
EP - 1195-1205
PB - WILEY
SN - 00142980
KW - B cells
KW - Breg
KW - IL‐ 10
KW - TLR9
KW - TNFR2
UR - https://onlinelibrary.wiley.com/journal/15214141
N2 - Tumor Necrosis Factor Receptor 2 (TNFR2) expression is increasingly being linked to tolerogenic immune reactions and cells with suppressor function including a subset of T-regulatory cells. B-regulatory cells play an important role in control of T-cell responses and inflammation. Recently, we described TNFR2 as a marker for IL-10-producing B cells, a hallmark of this cell subset. Here, we demonstrate that proliferation of T cells is reduced in the presence of TNFR2 positive human memory B cells generated with TLR9 ligand, while TNFR2- and TNFR2+CD27- B cells display costimulatory activity. Our data further reveal that IL-10 secretion is characteristic of IgM+ naive and memory B cells but suppressive activity is not restricted to IL-10: (i) the inhibitory effect of TNFR2+ switched memory B cells was comparable to that exerted by TNFR2+ IgM+ memory B cells although IL-10 secretion levels in the cocultures were lower; (ii) supernatants from TNFR2+ memory B cells failed to suppress T-cell proliferation. Based on our findings, we propose that formation of Breg is a specific characteristic of human memory B cells undergoing terminal differentiation. Our data further corroborate that TNFR2 represents a viable marker for identification of memory B cells with regulatory function.
ER -
TICHA, Olga, Peter SLANINA, Lukas MOOS, Julie ŠTÍCHOVÁ, Marcela VLKOVÁ a Isabelle BEKEREDJIAN-DING. TNFR2 expression is a hallmark of human memory B cells with suppressive function. \textit{EUROPEAN JOURNAL OF IMMUNOLOGY}. HOBOKEN: WILEY, 2021, roč.~51, č.~5, s.~1195-1205. ISSN~0014-2980. Dostupné z: https://dx.doi.org/10.1002/eji.202048988.
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