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@article{1770478,
author = {Sedláková, Veronika and McTiernan, Christopher and Cortes, David and Suuronen, Erik J. and Alarcon, Emilio I.},
article_location = {Basel},
article_number = {4},
doi = {http://dx.doi.org/10.1159/000512792},
keywords = {3D printing; Cardiac tissue; Valve; Maturation; Bioreactor},
language = {eng},
issn = {1422-6405},
journal = {Cells, tissues, organs},
title = {3D Bioprinted Cardiac Tissues and Devices for Tissue Maturation},
url = {https://www.karger.com/Article/FullText/512792},
volume = {211},
year = {2022}
}
TY - JOUR
ID - 1770478
AU - Sedláková, Veronika - McTiernan, Christopher - Cortes, David - Suuronen, Erik J. - Alarcon, Emilio I.
PY - 2022
TI - 3D Bioprinted Cardiac Tissues and Devices for Tissue Maturation
JF - Cells, tissues, organs
VL - 211
IS - 4
SP - 406-419
EP - 406-419
PB - Karger
SN - 14226405
KW - 3D printing
KW - Cardiac tissue
KW - Valve
KW - Maturation
KW - Bioreactor
UR - https://www.karger.com/Article/FullText/512792
N2 - Cardiovascular diseases are the leading cause of mortality worldwide. Given the limited endogenous regenerative capabilities of cardiac tissue, patient-specific anatomy, challenges in treatment options, and shortage of donor tissues for transplantation, there is an urgent need for novel approaches in cardiac tissue repair. 3D bioprinting is a technology based on additive manufacturing which allows for the design of precisely controlled and spatially organized structures, which could possibly lead to solutions in cardiac tissue repair. In this review, we describe the basic morphological and physiological specifics of the heart and cardiac tissues and introduce the readers to the fundamental principles underlying 3D printing technology and some of the materials/approaches which have been used to date for cardiac repair. By summarizing recent progress in 3D printing of cardiac tissue and valves with respect to the key features of cardiovascular tissue (such as contractility, conductivity, and vascularization), we highlight how 3D printing can facilitate surgical planning and provide custom-fit implants and properties that match those from the native heart. Finally, we also discuss the suitability of this technology in the design and fabrication of custom-made devices intended for the maturation of the cardiac tissue, a process that has been shown to increase the viability of implants. Altogether this review shows that 3D printing and bioprinting are versatile and highly modulative technologies with wide applications in cardiac regeneration and beyond.
ER -
SEDLÁKOVÁ, Veronika, Christopher MCTIERNAN, David CORTES, Erik J. SUURONEN and Emilio I. ALARCON. 3D Bioprinted Cardiac Tissues and Devices for Tissue Maturation. \textit{Cells, tissues, organs}. Basel: Karger, 2022, vol.~211, No~4, p.~406-419. ISSN~1422-6405. Available from: https://dx.doi.org/10.1159/000512792.
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