The Prevalence of Dysglycemia-Based Chronic Disease in a European Population - a New Paradigm to Address Diabetes Burden: A Kardiovize Study

GONZALEZ-RIVAS, J. P., J. I. MECHANICK, M. M. INFANTE-GARCIA, J. R. MEDINA-INOJOSA, Iuliia PAVLOVSKA, Ota HLINOMAZ, Petr ŽÁK, Sarka KUNZOVA, R. NIETO-MARTINEZ, Maria SKLADANA, Jan BROZ, J. P. HERNANDEZ, F. LOPEZ-JIMENEZ and G. B. STOKIN. The Prevalence of Dysglycemia-Based Chronic Disease in a European Population - a New Paradigm to Address Diabetes Burden: A Kardiovize Study. Endocrine Practice. Jacksonville: American Association of Clinical Endocrinology, 2021, vol. 27, No 5, p. 455-462. ISSN 1530-891X. Available from: https://dx.doi.org/10.1016/j.eprac.2020.10.003.

Basic information

Original name

The Prevalence of Dysglycemia-Based Chronic Disease in a European Population - a New Paradigm to Address Diabetes Burden: A Kardiovize Study

Authors

GONZALEZ-RIVAS, J. P. (guarantor), J. I. MECHANICK, M. M. INFANTE-GARCIA, J. R. MEDINA-INOJOSA, Iuliia PAVLOVSKA (804 Ukraine, belonging to the institution), Ota HLINOMAZ (203 Czech Republic), Petr ŽÁK (203 Czech Republic), Sarka KUNZOVA (203 Czech Republic), R. NIETO-MARTINEZ, Maria SKLADANA, Jan BROZ (203 Czech Republic), J. P. HERNANDEZ, F. LOPEZ-JIMENEZ and G. B. STOKIN

Edition

Endocrine Practice, Jacksonville, American Association of Clinical Endocrinology, 2021, 1530-891X

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30202 Endocrinology and metabolism

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.701

RIV identification code

RIV/00216224:14110/21:00121637

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.eprac.2020.10.003

UT WoS

000644659800012

Keywords in English

cardiovascular disease; diabetes; epidemiology; type 2 diabetes mellitus

Tags

14110525, rivok

Tags

International impact, Reviewed

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Abstract

V originále

Objective: To determine the prevalence rate and associated risk factors for each stage of the Dysglycemia-Based Chronic Disease (DBCD) model, which 4 distinct stages and prompts early prevention to avert Diabetes and cardiometabolic complications. Methods: Subjects between 25 and 64 years old from a random population-based sample were evaluated in Czechia from 2013 to 2014 using a cross-sectional design. DBCD stages were: stage 1 "insulin resistance" (inferred risk from abdominal obesity or a family history of diabetes); stage 2 "prediabetes"(fasting glucose between 5.6 and 6.9 mmol/L); stage 3 "type 2 diabetes (T2D)" (self-report of T2D or fasting glucose >= 7 mmol/L); and stage 4 "vascular complications" (T2D with cardiovascular disease). Results: A total of 2147 subjects were included (57.8% women) with a median age of 48 years. The prevalence of each DBCD stage were as follows: 54.2% (stage 1); 10.3% (stage 2), 3.7% (stage 3); and 1.2% (stage 4). Stages 2 to 4 were more frequent in men and stage 1 in women (P < .001). Using binary logistic regression analysis adjusting by age/sex, all DBCD stages were strongly associated with abnormal adiposity, hypertension, dyslipidemia, and smoking status. Subjects with lower educational levels and lower income were more likely to present DBCD. Conclusion: Using the new DBCD framework and available metrics, 69.4% of the population had DBCD, identifying far more people at risk than a simple prevalence rate for T2D (9.2% in Czechia, 2013-2014). All stages were associated with traditional cardiometabolic risk factors, implicating common pathophysiologic mechanisms and a potential for early preventive care. The social determinants of health were related with all DBCD stages in alarming proportions and will need to be further studied. (C) 2020 AACE. Published by Elsevier Inc.