WNT5B in Physiology and Disease

@article{1772100,
   author = {Suthon, Sarocha and Perkins, Rachel S. and Bryja, Vítězslav and MirandaandCarboni, Gustavo A. and Krum, Susan A.},
   article_location = {Lausanne},
   article_number = {May},
   doi = {http://dx.doi.org/10.3389/fcell.2021.667581},
   keywords = {WNT5B; WNT signaling; development; cancer; WNT5A},
   language = {eng},
   issn = {2296-634X},
   journal = {Frontiers in Cell and Developmental Biology},
   title = {WNT5B in Physiology and Disease},
   url = {https://www.frontiersin.org/articles/10.3389/fcell.2021.667581/full},
   volume = {09},
   year = {2021}
}

TY  - JOUR
ID  - 1772100
AU  - Suthon, Sarocha - Perkins, Rachel S. - Bryja, Vítězslav - Miranda-Carboni, Gustavo A. - Krum, Susan A.
PY  - 2021
TI  - WNT5B in Physiology and Disease
JF  - Frontiers in Cell and Developmental Biology
VL  - 09
IS  - May
SP  - "667581"
EP  - "667581"
PB  - Frontiers Media S.A.
SN  - 2296634X
KW  - WNT5B
KW  - WNT signaling
KW  - development
KW  - cancer
KW  - WNT5A
UR  - https://www.frontiersin.org/articles/10.3389/fcell.2021.667581/full
N2  - WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical beta-catenin-independent signaling pathway and often functions as an antagonist of canonical WNT signaling. Although WNT5B has a high amino acid identity with WNT5A and is often assumed to have similar activities, WNT5B often exhibits unique expression patterns and functions. Here, we describe the distinct effects and mechanisms of WNT5B on development, bone, adipose tissue, cardiac tissue, the nervous system, the mammary gland, the lung and hematopoietic cells, compared to WNT5A. We also highlight aberrances in non-canonical WNT5B signaling contributing to diseases such as osteoarthritis, osteoporosis, obesity, type 2 diabetes mellitus, neuropathology, and chronic diseases associated with aging, as well as various cancers.
ER  - 

SUTHON, Sarocha, Rachel S. PERKINS, Vítězslav BRYJA, Gustavo A. MIRANDA-CARBONI and Susan A. KRUM. WNT5B in Physiology and Disease. \textit{Frontiers in Cell and Developmental Biology}. Lausanne: Frontiers Media S.A., 2021, vol.~09, May, p.~''667581'', 20 pp. ISSN~2296-634X. Available from: https://dx.doi.org/10.3389/fcell.2021.667581.