| GRILLOVÁ, Linda, Jana MUSILOVA, Klára JANEČKOVÁ, Petra POSPÍŠILOVÁ, Ivana KUKLOVA, Vladana WOZNICOVÁ, Hana ZAKOUCKA and David ŠMAJS. The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals. INFECTION AND IMMUNITY. WASHINGTON: American Society for Microbiology, 2021, vol. 89, No 1, p. 1-6. ISSN 0019-9567. Available from: https://dx.doi.org/10.1128/IAI.00503-20. |
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@article{1773198,
author = {Grillová, Linda and Musilova, Jana and Janečková, Klára and Pospíšilová, Petra and Kuklova, Ivana and Woznicová, Vladana and Zakoucka, Hana and Šmajs, David},
article_location = {WASHINGTON},
article_number = {1},
doi = {http://dx.doi.org/10.1128/IAI.00503-20},
keywords = {Toll-like receptor 2; Treponema pallidum subsp. pallidum; Arg753Gln polymorphism; case-control study},
language = {eng},
issn = {0019-9567},
journal = {INFECTION AND IMMUNITY},
title = {The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals},
url = {https://journals.asm.org/doi/epub/10.1128/IAI.00503-20},
volume = {89},
year = {2021}
}
TY - JOUR
ID - 1773198
AU - Grillová, Linda - Musilova, Jana - Janečková, Klára - Pospíšilová, Petra - Kuklova, Ivana - Woznicová, Vladana - Zakoucka, Hana - Šmajs, David
PY - 2021
TI - The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals
JF - INFECTION AND IMMUNITY
VL - 89
IS - 1
SP - 1-6
EP - 1-6
PB - American Society for Microbiology
SN - 00199567
KW - Toll-like receptor 2
KW - Treponema pallidum subsp. pallidum
KW - Arg753Gln polymorphism
KW - case-control study
UR - https://journals.asm.org/doi/epub/10.1128/IAI.00503-20
N2 - Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum. Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and alter the responsiveness to, or the course of, various infectious diseases, including those caused by pathogenic spirochetes. To investigate whether TLR2 polymorphism may influence susceptibility to syphilis, 221 healthy individuals with no history of syphilis (controls) and 137 patients diagnosed with syphilis (cases) were screened for the presence of the Arg753Gln polymorphism in the TLR2 gene (2258G -> A; rs5743708). The Arg753Gln variant occurs at a significantly lower frequency in syphilis patients (4 of 137 [3%]) than in controls (24 of 221 [10.9%]). These data suggest that TLR2 Arg753Gln may protect from the development of syphilis due to reduced signaling.
ER -
GRILLOVÁ, Linda, Jana MUSILOVA, Klára JANEČKOVÁ, Petra POSPÍŠILOVÁ, Ivana KUKLOVA, Vladana WOZNICOVÁ, Hana ZAKOUCKA and David ŠMAJS. The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals. \textit{INFECTION AND IMMUNITY}. WASHINGTON: American Society for Microbiology, 2021, vol.~89, No~1, p.~1-6. ISSN~0019-9567. Available from: https://dx.doi.org/10.1128/IAI.00503-20.
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