The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower
Occurrence in Patients with Syphilis, Suggesting Its Protective
Effect in Czech and Slovak Individuals

J 2021

The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals

GRILLOVÁ, Linda, Jana MUSILOVA, Klára JANEČKOVÁ, Petra POSPÍŠILOVÁ, Ivana KUKLOVA et. al.

Basic information

Original name

The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals

Authors

GRILLOVÁ, Linda (203 Czech Republic, belonging to the institution), Jana MUSILOVA (203 Czech Republic), Klára JANEČKOVÁ (203 Czech Republic, belonging to the institution), Petra POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Ivana KUKLOVA (203 Czech Republic), Vladana WOZNICOVÁ (203 Czech Republic, belonging to the institution), Hana ZAKOUCKA (203 Czech Republic) and David ŠMAJS (203 Czech Republic, guarantor, belonging to the institution)

Edition

INFECTION AND IMMUNITY, WASHINGTON, American Society for Microbiology, 2021, 0019-9567

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30303 Infectious Diseases

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.609

RIV identification code

RIV/00216224:14110/21:00120100

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1128/IAI.00503-20

UT WoS

000600550700003

Keywords in English

Toll-like receptor 2; Treponema pallidum subsp. pallidum; Arg753Gln polymorphism; case-control study

Abstract

V originále

Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum. Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and alter the responsiveness to, or the course of, various infectious diseases, including those caused by pathogenic spirochetes. To investigate whether TLR2 polymorphism may influence susceptibility to syphilis, 221 healthy individuals with no history of syphilis (controls) and 137 patients diagnosed with syphilis (cases) were screened for the presence of the Arg753Gln polymorphism in the TLR2 gene (2258G -> A; rs5743708). The Arg753Gln variant occurs at a significantly lower frequency in syphilis patients (4 of 137 [3%]) than in controls (24 of 221 [10.9%]). These data suggest that TLR2 Arg753Gln may protect from the development of syphilis due to reduced signaling.

Links

MUNI/A/1325/2020, interní kód MU

Name: Biomedicínské vědy

Investor: Masaryk University

NV17-31333A, research and development project

Name: Vývoj nového typovacího systému pro původce syfilis, Treponema pallidum subsp. pallidum, zaměřeného na proteomické rozdíly

Citovat

GRILLOVÁ, Linda, Jana MUSILOVA, Klára JANEČKOVÁ, Petra POSPÍŠILOVÁ, Ivana KUKLOVA, Vladana WOZNICOVÁ, Hana ZAKOUCKA and David ŠMAJS. The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals. INFECTION AND IMMUNITY. WASHINGTON: American Society for Microbiology, 2021, vol. 89, No 1, p. 1-6. ISSN 0019-9567. Available from: https://dx.doi.org/10.1128/IAI.00503-20.

@article{1773198,
   author = {Grillová, Linda and Musilova, Jana and Janečková, Klára and Pospíšilová, Petra and Kuklova, Ivana and Woznicová, Vladana and Zakoucka, Hana and Šmajs, David},
   article_location = {WASHINGTON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1128/IAI.00503-20},
   keywords = {Toll-like receptor 2; Treponema pallidum subsp. pallidum; Arg753Gln polymorphism; case-control study},
   language = {eng},
   issn = {0019-9567},
   journal = {INFECTION AND IMMUNITY},
   title = {The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals},
   url = {https://journals.asm.org/doi/epub/10.1128/IAI.00503-20},
   volume = {89},
   year = {2021}
}

TY  - JOUR
ID  - 1773198
AU  - Grillová, Linda - Musilova, Jana - Janečková, Klára - Pospíšilová, Petra - Kuklova, Ivana - Woznicová, Vladana - Zakoucka, Hana - Šmajs, David
PY  - 2021
TI  - The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals
JF  - INFECTION AND IMMUNITY
VL  - 89
IS  - 1
SP  - 1-6
EP  - 1-6
PB  - American Society for Microbiology
SN  - 00199567
KW  - Toll-like receptor 2
KW  - Treponema pallidum subsp. pallidum
KW  - Arg753Gln polymorphism
KW  - case-control study
UR  - https://journals.asm.org/doi/epub/10.1128/IAI.00503-20
N2  - Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum. Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and alter the responsiveness to, or the course of, various infectious diseases, including those caused by pathogenic spirochetes. To investigate whether TLR2 polymorphism may influence susceptibility to syphilis, 221 healthy individuals with no history of syphilis (controls) and 137 patients diagnosed with syphilis (cases) were screened for the presence of the Arg753Gln polymorphism in the TLR2 gene (2258G -> A; rs5743708). The Arg753Gln variant occurs at a significantly lower frequency in syphilis patients (4 of 137 [3%]) than in controls (24 of 221 [10.9%]). These data suggest that TLR2 Arg753Gln may protect from the development of syphilis due to reduced signaling.
ER  -

GRILLOVÁ, Linda, Jana MUSILOVA, Klára JANEČKOVÁ, Petra POSPÍŠILOVÁ, Ivana KUKLOVA, Vladana WOZNICOVÁ, Hana ZAKOUCKA and David ŠMAJS. The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals. \textit{INFECTION AND IMMUNITY}. WASHINGTON: American Society for Microbiology, 2021, vol.~89, No~1, p.~1-6. ISSN~0019-9567. Available from: https://dx.doi.org/10.1128/IAI.00503-20.

Detailed Information on Publication Record