Detailed Information on Publication Record
2021
The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals
GRILLOVÁ, Linda, Jana MUSILOVA, Klára JANEČKOVÁ, Petra POSPÍŠILOVÁ, Ivana KUKLOVA et. al.Basic information
Original name
The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals
Authors
GRILLOVÁ, Linda (203 Czech Republic, belonging to the institution), Jana MUSILOVA (203 Czech Republic), Klára JANEČKOVÁ (203 Czech Republic, belonging to the institution), Petra POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Ivana KUKLOVA (203 Czech Republic), Vladana WOZNICOVÁ (203 Czech Republic, belonging to the institution), Hana ZAKOUCKA (203 Czech Republic) and David ŠMAJS (203 Czech Republic, guarantor, belonging to the institution)
Edition
INFECTION AND IMMUNITY, WASHINGTON, American Society for Microbiology, 2021, 0019-9567
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30303 Infectious Diseases
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 3.609
RIV identification code
RIV/00216224:14110/21:00120100
Organization unit
Faculty of Medicine
UT WoS
000600550700003
Keywords in English
Toll-like receptor 2; Treponema pallidum subsp. pallidum; Arg753Gln polymorphism; case-control study
Tags
International impact, Reviewed
Změněno: 21/2/2022 12:58, Mgr. Tereza Miškechová
Abstract
V originále
Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum. Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and alter the responsiveness to, or the course of, various infectious diseases, including those caused by pathogenic spirochetes. To investigate whether TLR2 polymorphism may influence susceptibility to syphilis, 221 healthy individuals with no history of syphilis (controls) and 137 patients diagnosed with syphilis (cases) were screened for the presence of the Arg753Gln polymorphism in the TLR2 gene (2258G -> A; rs5743708). The Arg753Gln variant occurs at a significantly lower frequency in syphilis patients (4 of 137 [3%]) than in controls (24 of 221 [10.9%]). These data suggest that TLR2 Arg753Gln may protect from the development of syphilis due to reduced signaling.
Links
MUNI/A/1325/2020, interní kód MU |
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NV17-31333A, research and development project |
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