TKADLEC, Jan, Vaclav CAPEK, Marie BRAJEROVA, Eva SMELIKOVA, Oto MELTER, Tamara BERGEROVA, Sylvia POLIVKOVA, Magda BALEJOVA, Marketa HANSLIANOVA, Daniela FACKOVA, Katerina NERADOVA, Renata TEJKALOVÁ, Iva VAGNEROVA, Natasa BARTONIKOVA, Eva CHMELAROVA, Pavel DREVINEK and Marcela KRUTOVA. The molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in the Czech Republic. Journal of Antimicrobial Chemotherapy. OXFORD: Oxford University Press, 2021, vol. 76, No 1, p. 55-64. ISSN 0305-7453. Available from: https://dx.doi.org/10.1093/jac/dkaa404.
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Basic information
Original name The molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in the Czech Republic
Authors TKADLEC, Jan (203 Czech Republic, guarantor), Vaclav CAPEK (203 Czech Republic), Marie BRAJEROVA (203 Czech Republic), Eva SMELIKOVA (203 Czech Republic), Oto MELTER (203 Czech Republic), Tamara BERGEROVA (203 Czech Republic), Sylvia POLIVKOVA (203 Czech Republic), Magda BALEJOVA (203 Czech Republic), Marketa HANSLIANOVA (203 Czech Republic), Daniela FACKOVA (203 Czech Republic), Katerina NERADOVA (203 Czech Republic), Renata TEJKALOVÁ (203 Czech Republic, belonging to the institution), Iva VAGNEROVA (203 Czech Republic), Natasa BARTONIKOVA (203 Czech Republic), Eva CHMELAROVA (203 Czech Republic), Pavel DREVINEK (203 Czech Republic) and Marcela KRUTOVA (203 Czech Republic).
Edition Journal of Antimicrobial Chemotherapy, OXFORD, Oxford University Press, 2021, 0305-7453.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10606 Microbiology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 5.758
RIV identification code RIV/00216224:14110/21:00121695
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1093/jac/dkaa404
UT WoS 000620811500006
Keywords in English molecular epidemiology; methicillin-resistant Staphylococcus aureus
Tags 14110113, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 2/6/2021 13:23.
Abstract
Objectives: To gain data on the current molecular epidemiology and resistance of MRSA in the Czech Republic. Methods: Between September 2017 and January 2018, a total of 441 single-patient MRSA isolates were collected from 11 Czech hospitals and analysed by spa typing, SCCmec typing, antibiotic susceptibility testing, detection of the PVL toxin and the arcA gene. Results: Of all MRSA isolates, 81.41% (n = 359) belonged to the CC5-MRSA clone represented by the spa types t003 (n = 136), t586 (n = 92), t014 (n = 81), t002 (n = 20) and other spa types (n = 30); a majority of the CC5 isolates (n = 348, 96.94%) carried SCCmec type II. The occurrence of CC5-MRSA was more Likely in older inpatients and associated with a healthcare origin (P< 0.001). The CC5-MRSA isolates were resistant to more antimicrobial drugs compared with the other MRSAs (P< 0.001). Interestingly, t586 was detected in blood samples more often than the other spa types and, contrary to other spa types belonging to CC5-MRSA, t586 was not associated with patients of advanced age. Other frequently found Lineages were CC8 (n = 17), CC398 (n = 11) and CC59 (n = 10). The presence of the PVL was detected in 8.62% (n = 38) of the MRSA isolates. Conclusions: The healthcare-associated CC5-MRSA-II Lineage (t003, t586, t014) was found to be predominant in the Czech Republic. t586 is a newly emerging spa type in the Czech Republic, yet reported rarely in other countries. Our observations stress the need for MRSA surveillance in the Czech Republic in order to monitor changes in MRSA epidemiology.
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