Urine immunofixation negativity is not necessary for complete
response in intact immunoglobulin multiple myeloma:
Retrospective real-world confirmation

J 2021

Urine immunofixation negativity is not necessary for complete response in intact immunoglobulin multiple myeloma: Retrospective real-world confirmation

RADOCHA, Jakub, Tomas JELINEK, Luděk POUR, Ivan SPICKA, Jiri MINARIK et. al.

Basic information

Original name

Urine immunofixation negativity is not necessary for complete response in intact immunoglobulin multiple myeloma: Retrospective real-world confirmation

Authors

RADOCHA, Jakub (203 Czech Republic, guarantor), Tomas JELINEK (203 Czech Republic), Luděk POUR (203 Czech Republic, belonging to the institution), Ivan SPICKA (203 Czech Republic), Jiri MINARIK (203 Czech Republic), Tereza POPKOVA (203 Czech Republic), Alexandra JUNGOVA (203 Czech Republic), Petr PAVLICEK (203 Czech Republic), Lucie BROŽOVÁ (203 Czech Republic), Martin ŠTORK (203 Czech Republic, belonging to the institution), Frantisek SEDLAK (203 Czech Republic), Petra KRHOVSKA (203 Czech Republic), Vladimir MAISNAR (203 Czech Republic), Adriana HEINDORFER (203 Czech Republic), Michal SYKORA (203 Czech Republic), Marek WROBEL (203 Czech Republic), Peter MIKULA (203 Czech Republic), Petr KESSLER (203 Czech Republic), Jana ULLRYCHOVA (203 Czech Republic) and Roman HAJEK (203 Czech Republic)

Edition

International Journal of Laboratory Hematology, MALDEN, WILEY-BLACKWELL, 2021, 1751-5521

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30205 Hematology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.450

RIV identification code

RIV/00216224:14110/21:00121704

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/ijlh.13460

UT WoS

000607843000001

Keywords in English

Urine immunofixation negativity; intact immunoglobulin multiple myeloma

Abstract

V originále

The definition of complete disease response (CR) in multiple myeloma (MM) continues to be reevaluated. The last widely accepted model of response assessment was proposed by the International Myeloma Working Group (IMWG) in 2016.1 Urine immunofixation (uIFE), one of the CR parameters, is being frequently omitted from CR evaluation in routine clinical practice. Patients with missing uIFE are then reported as having very good partial response (VGPR).2 It has been recently suggested in retrospective analysis by Lahuerta et al3 that patients with intact immunoglobulin myeloma (IIMM) who lack uIFE examination present with the very same prognosis as the patients with negative uIFE and therefore uIFE might not be necessary for CR definition in such patients.

Citovat

RADOCHA, Jakub, Tomas JELINEK, Luděk POUR, Ivan SPICKA, Jiri MINARIK, Tereza POPKOVA, Alexandra JUNGOVA, Petr PAVLICEK, Lucie BROŽOVÁ, Martin ŠTORK, Frantisek SEDLAK, Petra KRHOVSKA, Vladimir MAISNAR, Adriana HEINDORFER, Michal SYKORA, Marek WROBEL, Peter MIKULA, Petr KESSLER, Jana ULLRYCHOVA and Roman HAJEK. Urine immunofixation negativity is not necessary for complete response in intact immunoglobulin multiple myeloma: Retrospective real-world confirmation. International Journal of Laboratory Hematology. MALDEN: WILEY-BLACKWELL, 2021, vol. 43, No 5, p. "E244"-"E247", 4 pp. ISSN 1751-5521. Available from: https://dx.doi.org/10.1111/ijlh.13460.

@article{1773329,
   author = {Radocha, Jakub and Jelinek, Tomas and Pour, Luděk and Spicka, Ivan and Minarik, Jiri and Popkova, Tereza and Jungova, Alexandra and Pavlicek, Petr and Brožová, Lucie and Štork, Martin and Sedlak, Frantisek and Krhovska, Petra and Maisnar, Vladimir and Heindorfer, Adriana and Sykora, Michal and Wrobel, Marek and Mikula, Peter and Kessler, Petr and Ullrychova, Jana and Hajek, Roman},
   article_location = {MALDEN},
   article_number = {5},
   doi = {http://dx.doi.org/10.1111/ijlh.13460},
   keywords = {Urine immunofixation negativity; intact immunoglobulin multiple myeloma},
   language = {eng},
   issn = {1751-5521},
   journal = {International Journal of Laboratory Hematology},
   title = {Urine immunofixation negativity is not necessary for complete response in intact immunoglobulin multiple myeloma: Retrospective real-world confirmation},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/ijlh.13460},
   volume = {43},
   year = {2021}
}

TY  - JOUR
ID  - 1773329
AU  - Radocha, Jakub - Jelinek, Tomas - Pour, Luděk - Spicka, Ivan - Minarik, Jiri - Popkova, Tereza - Jungova, Alexandra - Pavlicek, Petr - Brožová, Lucie - Štork, Martin - Sedlak, Frantisek - Krhovska, Petra - Maisnar, Vladimir - Heindorfer, Adriana - Sykora, Michal - Wrobel, Marek - Mikula, Peter - Kessler, Petr - Ullrychova, Jana - Hajek, Roman
PY  - 2021
TI  - Urine immunofixation negativity is not necessary for complete response in intact immunoglobulin multiple myeloma: Retrospective real-world confirmation
JF  - International Journal of Laboratory Hematology
VL  - 43
IS  - 5
SP  - "E244"-"E247"
EP  - "E244"-"E247"
PB  - WILEY-BLACKWELL
SN  - 17515521
KW  - Urine immunofixation negativity
KW  - intact immunoglobulin multiple myeloma
UR  - https://onlinelibrary.wiley.com/doi/10.1111/ijlh.13460
N2  - The definition of complete disease response (CR) in multiple myeloma (MM) continues to be reevaluated. The last widely accepted model of response assessment was proposed by the International Myeloma Working Group (IMWG) in 2016.1 Urine immunofixation (uIFE), one of the CR parameters, is being frequently omitted from CR evaluation in routine clinical practice. Patients with missing uIFE are then reported as having very good partial response (VGPR).2 It has been recently suggested in retrospective analysis by Lahuerta et al3 that patients with intact immunoglobulin myeloma (IIMM) who lack uIFE examination present with the very same prognosis as the patients with negative uIFE and therefore uIFE might not be necessary for CR definition in such patients.
ER  -

RADOCHA, Jakub, Tomas JELINEK, Luděk POUR, Ivan SPICKA, Jiri MINARIK, Tereza POPKOVA, Alexandra JUNGOVA, Petr PAVLICEK, Lucie BROŽOVÁ, Martin ŠTORK, Frantisek SEDLAK, Petra KRHOVSKA, Vladimir MAISNAR, Adriana HEINDORFER, Michal SYKORA, Marek WROBEL, Peter MIKULA, Petr KESSLER, Jana ULLRYCHOVA and Roman HAJEK. Urine immunofixation negativity is not necessary for complete response in intact immunoglobulin multiple myeloma: Retrospective real-world confirmation. \textit{International Journal of Laboratory Hematology}. MALDEN: WILEY-BLACKWELL, 2021, vol.~43, No~5, p.~''E244''-''E247'', 4 pp. ISSN~1751-5521. Available from: https://dx.doi.org/10.1111/ijlh.13460.

Detailed Information on Publication Record