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@article{1774937,
author = {Neil, Dani and Herbst, Rebecca H. and McCabe, Cristin and Green, Gilad S. and Kaiser, Karol and Head, Joshua P. and Cui, Jin and Shipley, Frederick B. and Jang, Ahram and Dionne, Danielle and Nguyen, Lan and Rodman, Christopher and Riesenfeld, Samantha J. and Prochazka, Jan and Prochazkova, Michaela and Sedlacek, Radislav and Zhang, Feng and Bryja, Vítězslav and RozenblattandRosen, Orit and Habib, Naomi and Regev, Aviv and Lehtinen, Maria K},
article_location = {Cambridge},
article_number = {11},
doi = {http://dx.doi.org/10.1016/j.cell.2021.04.003},
keywords = {choroid plexus; brain barrier; cerebrospinal fluid; single-cell RNA sequencing; single-nucleus RNA sequencing; aging; development},
language = {eng},
issn = {0092-8674},
journal = {Cell},
title = {A cellular and spatial map of the choroid plexus across brain ventricles and ages},
url = {https://doi.org/10.1016/j.cell.2021.04.003},
volume = {184},
year = {2021}
}
TY - JOUR
ID - 1774937
AU - Neil, Dani - Herbst, Rebecca H. - McCabe, Cristin - Green, Gilad S. - Kaiser, Karol - Head, Joshua P. - Cui, Jin - Shipley, Frederick B. - Jang, Ahram - Dionne, Danielle - Nguyen, Lan - Rodman, Christopher - Riesenfeld, Samantha J. - Prochazka, Jan - Prochazkova, Michaela - Sedlacek, Radislav - Zhang, Feng - Bryja, Vítězslav - Rozenblatt-Rosen, Orit - Habib, Naomi - Regev, Aviv - Lehtinen, Maria K
PY - 2021
TI - A cellular and spatial map of the choroid plexus across brain ventricles and ages
JF - Cell
VL - 184
IS - 11
SP - "3056-3074", "e1-e21"
EP - "3056-3074", "e1-e21"
PB - Cell Press
SN - 00928674
KW - choroid plexus
KW - brain barrier
KW - cerebrospinal fluid
KW - single-cell RNA sequencing
KW - single-nucleus RNA sequencing
KW - aging
KW - development
UR - https://doi.org/10.1016/j.cell.2021.04.003
N2 - The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. We delineate diverse cell types, subtypes, cell states, and expression programs in epithelial and mesenchymal cells across ages and ventricles. In the developing ChP, we predict a common progenitor pool for epithelial and neuronal cells, validated by lineage tracing. Epithelial and fibroblast cells show regionalized expression by ventricle, starting at embryonic stages and persisting with age, with a dramatic transcriptional shift with maturation, and a smaller shift in each aged cell type. With aging, epithelial cells upregulate host-defense programs, and resident macrophages upregulate interleukin-1 beta (IL-1 beta) signaling genes. Our atlas reveals cellular diversity, architecture and signaling across ventricles during development, maturation, and aging of the ChP-brain barrier.
ER -
NEIL, Dani, Rebecca H. HERBST, Cristin MCCABE, Gilad S. GREEN, Karol KAISER, Joshua P. HEAD, Jin CUI, Frederick B. SHIPLEY, Ahram JANG, Danielle DIONNE, Lan NGUYEN, Christopher RODMAN, Samantha J. RIESENFELD, Jan PROCHAZKA, Michaela PROCHAZKOVA, Radislav SEDLACEK, Feng ZHANG, Vítězslav BRYJA, Orit ROZENBLATT-ROSEN, Naomi HABIB, Aviv REGEV and Maria K LEHTINEN. A cellular and spatial map of the choroid plexus across brain ventricles and ages. \textit{Cell}. Cambridge: Cell Press, 2021, vol.~184, No~11, p.~''3056-3074'', ''e1-e21'', 40 pp. ISSN~0092-8674. Available from: https://dx.doi.org/10.1016/j.cell.2021.04.003.
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