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@article{1776157,
author = {Zvárová, Veronika and Dolina, Jiří and Šenkyřík, Michal and Kroupa, Radek and Horňáková, Ľubomíra and Jabandžiev, Petr and Hrabovský, Štěpán and Číhalová, Marta and Hustý, Jakub and Mytsak, Kornelia and Kunovský, Lumír},
article_location = {Praha},
article_number = {3},
doi = {http://dx.doi.org/10.36290/vnl.2021.048},
keywords = {pregnancy; gravidity; liver; cirrhosis; varices; transjugular intrahepatic portosystemic shunt; lymphoma},
language = {eng},
issn = {0042-773X},
journal = {Vnitřní lékařství},
title = {Liver cirrhosis and pregnancy: a case report and review of literature},
url = {https://casopisvnitrnilekarstvi.cz/artkey/vnl-202103-0015_liver-cirrhosis-and-pregnancy-a-case-report-and-review-of-literature.php},
volume = {67},
year = {2021}
}
TY - JOUR
ID - 1776157
AU - Zvárová, Veronika - Dolina, Jiří - Šenkyřík, Michal - Kroupa, Radek - Horňáková, Ľubomíra - Jabandžiev, Petr - Hrabovský, Štěpán - Číhalová, Marta - Hustý, Jakub - Mytsak, Kornelia - Kunovský, Lumír
PY - 2021
TI - Liver cirrhosis and pregnancy: a case report and review of literature
JF - Vnitřní lékařství
VL - 67
IS - 3
SP - "e28"-"e32"
EP - "e28"-"e32"
PB - Česká internistická společnost J.E. Purk
SN - 0042773X
KW - pregnancy
KW - gravidity
KW - liver
KW - cirrhosis
KW - varices
KW - transjugular intrahepatic portosystemic shunt
KW - lymphoma
UR - https://casopisvnitrnilekarstvi.cz/artkey/vnl-202103-0015_liver-cirrhosis-and-pregnancy-a-case-report-and-review-of-literature.php
N2 - Liver cirrhosis is a chronic liver disease in which the liver tissue and the vascular beds are remodeled leading to impaired hepatic function. Portal hypertension and subsequent esophageal varices are a frequent complication of liver cirrhosis and are a cause of mortality in patients with liver cirrhosis. Pregnancy in women with liver cirrhosis is uncommon, the incidence being about 1 in 5 950 pregnancies. Hepatocellular damage and the associated alteration in the metabolism of the sex hormones is thought to be responsible and leads to anovulation. In spite of all these factors, women with cirrhosis can and do become pregnant. Pregnancy is successful in most of the patients with chronic liver disease, but maternal and fetal complication rates are still high for decompensated liver cirrhosis. Portal hypertension associated with pregnancy is a high-risk situation as both pregnancy and portal hypertension share some of the hemodynamic changes. Risks of variceal bleeding and hepatic decompensation increases many fold during pregnancy. Despite the possible complications mentioned above, the maternal-fetal morbidity and mortality rates have been decreased by the current developments in hepatology, prevention of bleeding from varices with drugs and/or endoscopic variceal ligation, improvement in liver transplantation, and an increased experience in these issues. We present a case of a 31-year-old female patient with liver cirrhosis who successfully managed pregnancy and birth without complications after the insertion of transjugular intrahepatic portosystemic shunt (TIPS). Unfortunately, 2 years after delivery, the patient developed lymphoblastic lymphoma and, despite intensive therapy for this disease, the patient died at the age of 40. We did not find any link between liver cirrhosis and lymphoblastic lymphoma.
ER -
ZVÁROVÁ, Veronika, Jiří DOLINA, Michal ŠENKYŘÍK, Radek KROUPA, Ľubomíra HORŇÁKOVÁ, Petr JABANDŽIEV, Štěpán HRABOVSKÝ, Marta ČÍHALOVÁ, Jakub HUSTÝ, Kornelia MYTSAK and Lumír KUNOVSKÝ. Liver cirrhosis and pregnancy: a case report and review of literature. \textit{Vnitřní lékařství}. Praha: Česká internistická společnost J.E. Purk, 2021, vol.~67, No~3, p.~''e28''-''e32'', 4 pp. ISSN~0042-773X. Available from: https://dx.doi.org/10.36290/vnl.2021.048.
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