| KRTIČKA, Milan, Lenka MICHLOVSKA, Vladimír NEKUDA, Petr POLACEK, Kristyna VALOVA, Jan ZIDEK, Jozef KAISER, Tomas ZIKMUND and Lucy VOJTOVA. Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue. Journal of the Mechanical Behavior of Biomedical Materials. Elsevier: Amsterdam, 2021, vol. 115, MAR 2021, p. 1-8. ISSN 1751-6161. Available from: https://dx.doi.org/10.1016/j.jmbbm.2020.104249. |
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@article{1776218,
author = {Krtička, Milan and Michlovska, Lenka and Nekuda, Vladimír and Polacek, Petr and Valova, Kristyna and Zidek, Jan and Kaiser, Jozef and Zikmund, Tomas and Vojtova, Lucy},
article_location = {Elsevier},
article_number = {MAR 2021},
doi = {http://dx.doi.org/10.1016/j.jmbbm.2020.104249},
keywords = {Adhesive; Fracture; Bone; Ex-vivo; Biomechanics; Rheology; Thixotropy; Biodegradable polymer; Microtomography},
language = {eng},
issn = {1751-6161},
journal = {Journal of the Mechanical Behavior of Biomedical Materials},
title = {Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue},
url = {https://www.sciencedirect.com/science/article/pii/S1751616120307888?via%3Dihub},
volume = {115},
year = {2021}
}
TY - JOUR
ID - 1776218
AU - Krtička, Milan - Michlovska, Lenka - Nekuda, Vladimír - Polacek, Petr - Valova, Kristyna - Zidek, Jan - Kaiser, Jozef - Zikmund, Tomas - Vojtova, Lucy
PY - 2021
TI - Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue
JF - Journal of the Mechanical Behavior of Biomedical Materials
VL - 115
IS - MAR 2021
SP - 1-8
EP - 1-8
PB - Amsterdam
SN - 17516161
KW - Adhesive
KW - Fracture
KW - Bone
KW - Ex-vivo
KW - Biomechanics
KW - Rheology
KW - Thixotropy
KW - Biodegradable polymer
KW - Microtomography
UR - https://www.sciencedirect.com/science/article/pii/S1751616120307888?via%3Dihub
N2 - Aims: The aim of this study was to answer the question whether our newly developed injectable biodegradable "self-setting" polymer-composite as a bone adhesive is a good "bone-glue" candidate to efficiently fix comminuted fractures of pig femoral bones used as an ex-vivo experimental model. Methods: Mechanical properties of adhesive prepared from mtricalcium phosphate (TCP) powder and thermogelling copolymer were optimized by selecting the appropriate composition with adhesion enhancers based on dopamine and sodium iodinate. Setting time and injectability were controlled by rheology. Ex-vivo experiments of fixed pig bones were provided in terms of either the three-point bending test of bending wedge type fractured pig femurs (with LCP) or the axial compression test of 45 degrees oblique fractured femurs (without LCP) in physiological saline solution at 37 degrees C. Fractured bones treated with optimized adhesive before and after bending tests were imaged by X-ray microtomography (mu CT). Results: Based on the rheological measurement, the adhesive modified with both dopamine and sodium iodinate exhibited optimal thixotropic properties required for injection via thin 22 G needle. This optimal adhesive composition showed an 8 min lag phase (processing time) followed by fast increase in storage modulus at 37 degrees C up to 1 GPa within 110 min. Self-setting of dopamine/iodinate modified adhesive was completed in 48 h exhibiting the maximum strength at compression of 7.98 MPa +/- 1.39 MPa. Whereas unmodified adhesive failed in glue-to-bone adhesion, dopamine and dopamine/iodinate modified adhesive used for 45 degrees oblique fracture fixation showed good and similar strength at compression (3.05 and 2.79 MPa, respectively). However, significantly higher elasticity of about 250% exhibited adhesive with iodinate enhancer. Moreover, mechanical properties of B2 fractures fixed with both LCP and dopamine/iodinate adhesive were approaching closely to the properties of original bone. Excellent adhesion between the adhesive and the bone fragments was proved by mu CT. Conclusion: The polymer-composite bone adhesive modified with dopamine/iodinate exhibited very good fixation ability of femoral artificial comminuted fractures in an experimental model.
ER -
KRTIČKA, Milan, Lenka MICHLOVSKA, Vladimír NEKUDA, Petr POLACEK, Kristyna VALOVA, Jan ZIDEK, Jozef KAISER, Tomas ZIKMUND and Lucy VOJTOVA. Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue. \textit{Journal of the Mechanical Behavior of Biomedical Materials}. Elsevier: Amsterdam, 2021, vol.~115, MAR 2021, p.~1-8. ISSN~1751-6161. Available from: https://dx.doi.org/10.1016/j.jmbbm.2020.104249.
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