Fibroblasts: The grey eminence of mammary gland development

SUMBAL, Jakub, Denisa BELISOVÁ and Zuzana KOLEDOVÁ. Fibroblasts: The grey eminence of mammary gland development. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, vol. 114, JUN 2021, p. 134-142. ISSN 1084-9521. Available from: https://dx.doi.org/10.1016/j.semcdb.2020.10.012.

Basic information

• Original name: Fibroblasts: The grey eminence of mammary gland development
• Authors: SUMBAL, Jakub (203 Czech Republic, belonging to the institution), Denisa BELISOVÁ (703 Slovakia, belonging to the institution) and Zuzana KOLEDOVÁ (703 Slovakia, guarantor, belonging to the institution).
• Edition: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, LONDON, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, 1084-9521.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10601 Cell biology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 7.499
• RIV identification code: RIV/00216224:14110/21:00121780
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.semcdb.2020.10.012
• UT WoS: 000653461300003
• Keywords in English: Breast; Epithelial-stromal interactions; Fibroblast; Heterogeneity; Mammary gland; Microenvironment
• Tags: 14110517, rivok
• Tags: International impact, Reviewed

Abstract

The essential role of mammary gland stroma in the regulation of mammary epithelial development, function, and cancer has long been recognized. Only recently, though, the functions of individual stromal cell populations have begun to become more clarified. Mammary fibroblasts have emerged as master regulators and modulators of epithelial cell behavior through paracrine signaling, extracellular matrix production and remodeling, and through regulation of other stromal cell types. In this review article, we summarize the crucial studies that helped to untangle the roles of fibroblasts in mammary gland development. Furthermore, we discuss the origin, heterogeneity, and plasticity of mammary fibroblasts during mammary development and cancer progression.

Links

• MUNI/G/1446/2018, interní kód MU: Name: Deciphering the mechanisms of mammary epithelial branched pattern formation through iterative biological and mathematical modelling

Investor: Masaryk University, INTERDISCIPLINARY - Interdisciplinary research projects

• ROZV/28/LF19/2020, interní kód MU: Name: Regulace morfogeneze epitelu mléčné žlázy pomocí mechanických sil a dynamiky signalizace

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects