Fibroblasts: The grey eminence of mammary gland development

J 2021

Fibroblasts: The grey eminence of mammary gland development

SUMBAL, Jakub, Denisa BELISOVÁ and Zuzana KOLEDOVÁ

Basic information

Original name

Fibroblasts: The grey eminence of mammary gland development

Authors

SUMBAL, Jakub (203 Czech Republic, belonging to the institution), Denisa BELISOVÁ (703 Slovakia, belonging to the institution) and Zuzana KOLEDOVÁ (703 Slovakia, guarantor, belonging to the institution)

Edition

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, LONDON, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, 1084-9521

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.499

RIV identification code

RIV/00216224:14110/21:00121780

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.semcdb.2020.10.012

UT WoS

000653461300003

Keywords in English

Breast; Epithelial-stromal interactions; Fibroblast; Heterogeneity; Mammary gland; Microenvironment

Abstract

V originále

The essential role of mammary gland stroma in the regulation of mammary epithelial development, function, and cancer has long been recognized. Only recently, though, the functions of individual stromal cell populations have begun to become more clarified. Mammary fibroblasts have emerged as master regulators and modulators of epithelial cell behavior through paracrine signaling, extracellular matrix production and remodeling, and through regulation of other stromal cell types. In this review article, we summarize the crucial studies that helped to untangle the roles of fibroblasts in mammary gland development. Furthermore, we discuss the origin, heterogeneity, and plasticity of mammary fibroblasts during mammary development and cancer progression.

Links

MUNI/G/1446/2018, interní kód MU

Name: Deciphering the mechanisms of mammary epithelial branched pattern formation through iterative biological and mathematical modelling

Investor: Masaryk University, INTERDISCIPLINARY - Interdisciplinary research projects

ROZV/28/LF19/2020, interní kód MU

Name: Regulace morfogeneze epitelu mléčné žlázy pomocí mechanických sil a dynamiky signalizace

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

SUMBAL, Jakub, Denisa BELISOVÁ and Zuzana KOLEDOVÁ. Fibroblasts: The grey eminence of mammary gland development. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, vol. 114, JUN 2021, p. 134-142. ISSN 1084-9521. Available from: https://dx.doi.org/10.1016/j.semcdb.2020.10.012.

@article{1776282,
   author = {Sumbal, Jakub and Belisová, Denisa and Koledová, Zuzana},
   article_location = {LONDON},
   article_number = {JUN 2021},
   doi = {http://dx.doi.org/10.1016/j.semcdb.2020.10.012},
   keywords = {Breast; Epithelial-stromal interactions; Fibroblast; Heterogeneity; Mammary gland; Microenvironment},
   language = {eng},
   issn = {1084-9521},
   journal = {SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY},
   title = {Fibroblasts: The grey eminence of mammary gland development},
   url = {https://www.sciencedirect.com/science/article/pii/S1084952120301695?via%3Dihub},
   volume = {114},
   year = {2021}
}

TY  - JOUR
ID  - 1776282
AU  - Sumbal, Jakub - Belisová, Denisa - Koledová, Zuzana
PY  - 2021
TI  - Fibroblasts: The grey eminence of mammary gland development
JF  - SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
VL  - 114
IS  - JUN 2021
SP  - 134-142
EP  - 134-142
PB  - ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
SN  - 10849521
KW  - Breast
KW  - Epithelial-stromal interactions
KW  - Fibroblast
KW  - Heterogeneity
KW  - Mammary gland
KW  - Microenvironment
UR  - https://www.sciencedirect.com/science/article/pii/S1084952120301695?via%3Dihub
N2  - The essential role of mammary gland stroma in the regulation of mammary epithelial development, function, and cancer has long been recognized. Only recently, though, the functions of individual stromal cell populations have begun to become more clarified. Mammary fibroblasts have emerged as master regulators and modulators of epithelial cell behavior through paracrine signaling, extracellular matrix production and remodeling, and through regulation of other stromal cell types. In this review article, we summarize the crucial studies that helped to untangle the roles of fibroblasts in mammary gland development. Furthermore, we discuss the origin, heterogeneity, and plasticity of mammary fibroblasts during mammary development and cancer progression.
ER  -

SUMBAL, Jakub, Denisa BELISOVÁ and Zuzana KOLEDOVÁ. Fibroblasts: The grey eminence of mammary gland development. \textit{SEMINARS IN CELL \&{} DEVELOPMENTAL BIOLOGY}. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, vol.~114, JUN 2021, p.~134-142. ISSN~1084-9521. Available from: https://dx.doi.org/10.1016/j.semcdb.2020.10.012.

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