Diffusion kurtosis imaging detects the time-dependent progress
of pathological changes in the oral rotenone mouse model of
Parkinson's disease

J 2021

Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease

KHAIRNAR, Amit Suresh, Jana RUDÁ, Anas ARAB, Constantinos HADJISTYLLIS, Alžběta ŠEJNOHA MINSTEROVÁ et. al.

Basic information

Original name

Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease

Name in Czech

Zobrazování kurtózy difuze detekuje časový průběh patologických změn v perorálním rotenonovém myším modelu Parkinsonovy nemoci

Authors

KHAIRNAR, Amit Suresh (356 India, belonging to the institution), Jana RUDÁ (203 Czech Republic, guarantor, belonging to the institution), Anas ARAB (760 Syrian Arab Republic, belonging to the institution), Constantinos HADJISTYLLIS (276 Germany), Alžběta ŠEJNOHA MINSTEROVÁ (203 Czech Republic, belonging to the institution), Qi SHANG (276 Germany), Alexandra CHOVSEPAIN (276 Germany), Eva DRAŽANOVÁ (203 Czech Republic, belonging to the institution), Nikoletta SZABÓ (348 Hungary, belonging to the institution), Zenon STARČUK (203 Czech Republic), Irena REKTOROVÁ (203 Czech Republic, belonging to the institution) and Francisco PAN-MONTOJO (276 Germany)

Edition

Journal of Neurochemistry, HOBOKEN, Wiley-Blackwell, 2021, 0022-3042

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.546

RIV identification code

RIV/00216224:14740/21:00120106

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1111/jnc.15449

UT WoS

000669590100001

Keywords in English

alpha synuclein; diffusion kurtosis imaging; MRI; Parkinsons disease; rotenone; tract-based spatial statistics

Abstract

V originále

We test the utility and sensitivity of the diffusion kurtosis imaging (DKI) in detecting progressive microstructural changes in several brain regions of mice exposed to chronic intragastric administration of rotenone,a mouse model that mimics the spatiotemporal progression of PD-like pathology from the ENS to the SN as described by Braak's staging.

Links

EF16_013/0001775, research and development project

Name: Modernizace a podpora výzkumných aktivit národní infrastruktury pro biologické a medicínské zobrazování Czech-BioImaging

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

MUNI/A/1249/2020, interní kód MU

Name: Základní výzkum v oblasti farmakokinetiky, neurobiologie závislostí a aplikovaný výzkum v oblasti personalizované farmakoterapie v onkologii (Acronym: SV_Farmakologie2021)

Investor: Masaryk University

NU20-04-00294, research and development project

Name: Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat

Investor: Ministry of Health of the CR, Diagnostics of Lewy body diseases in prodromal stage based on multimodal data analysis

90062, large research infrastructures

Name: Czech-BioImaging

Citovat

KHAIRNAR, Amit Suresh, Jana RUDÁ, Anas ARAB, Constantinos HADJISTYLLIS, Alžběta ŠEJNOHA MINSTEROVÁ, Qi SHANG, Alexandra CHOVSEPAIN, Eva DRAŽANOVÁ, Nikoletta SZABÓ, Zenon STARČUK, Irena REKTOROVÁ and Francisco PAN-MONTOJO. Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease. Journal of Neurochemistry. HOBOKEN: Wiley-Blackwell, 2021, vol. 158, No 3, p. 779-797. ISSN 0022-3042. Available from: https://dx.doi.org/10.1111/jnc.15449.

@article{1777967,
   author = {Khairnar, Amit Suresh and Rudá, Jana and Arab, Anas and Hadjistyllis, Constantinos and Šejnoha Minsterová, Alžběta and Shang, Qi and Chovsepain, Alexandra and Dražanová, Eva and Szabó, Nikoletta and Starčuk, Zenon and Rektorová, Irena and PanandMontojo, Francisco},
   article_location = {HOBOKEN},
   article_number = {3},
   doi = {http://dx.doi.org/10.1111/jnc.15449},
   keywords = {alpha synuclein; diffusion kurtosis imaging; MRI; Parkinsons disease; rotenone; tract-based spatial statistics},
   language = {eng},
   issn = {0022-3042},
   journal = {Journal of Neurochemistry},
   title = {Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/jnc.15449},
   volume = {158},
   year = {2021}
}

TY  - JOUR
ID  - 1777967
AU  - Khairnar, Amit Suresh - Rudá, Jana - Arab, Anas - Hadjistyllis, Constantinos - Šejnoha Minsterová, Alžběta - Shang, Qi - Chovsepain, Alexandra - Dražanová, Eva - Szabó, Nikoletta - Starčuk, Zenon - Rektorová, Irena - Pan-Montojo, Francisco
PY  - 2021
TI  - Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease
JF  - Journal of Neurochemistry
VL  - 158
IS  - 3
SP  - 779-797
EP  - 779-797
PB  - Wiley-Blackwell
SN  - 00223042
KW  - alpha synuclein
KW  - diffusion kurtosis imaging
KW  - MRI
KW  - Parkinsons disease
KW  - rotenone
KW  - tract-based spatial statistics
UR  - https://onlinelibrary.wiley.com/doi/10.1111/jnc.15449
N2  - We test the utility and sensitivity of the diffusion kurtosis imaging (DKI) in detecting progressive microstructural changes in several brain regions of mice exposed to chronic intragastric administration of rotenone,a mouse model that mimics the spatiotemporal progression of PD-like pathology from the ENS to the SN as described by Braak's staging.
ER  -

KHAIRNAR, Amit Suresh, Jana RUDÁ, Anas ARAB, Constantinos HADJISTYLLIS, Alžběta ŠEJNOHA MINSTEROVÁ, Qi SHANG, Alexandra CHOVSEPAIN, Eva DRAŽANOVÁ, Nikoletta SZABÓ, Zenon STARČUK, Irena REKTOROVÁ and Francisco PAN-MONTOJO. Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease. \textit{Journal of Neurochemistry}. HOBOKEN: Wiley-Blackwell, 2021, vol.~158, No~3, p.~779-797. ISSN~0022-3042. Available from: https://dx.doi.org/10.1111/jnc.15449.

Detailed Information on Publication Record