Detailed Information on Publication Record
2021
COVID-19's natural course among ambulatory monitored outpatients
WEINBERGEROVÁ, Barbora, Jiří MAYER, Štěpán HRABOVSKÝ, Zuzana NOVÁKOVÁ, Zdeněk POSPÍŠIL et. al.Basic information
Original name
COVID-19's natural course among ambulatory monitored outpatients
Authors
WEINBERGEROVÁ, Barbora (203 Czech Republic, guarantor, belonging to the institution), Jiří MAYER (203 Czech Republic, belonging to the institution), Štěpán HRABOVSKÝ (203 Czech Republic, belonging to the institution), Zuzana NOVÁKOVÁ (203 Czech Republic, belonging to the institution), Zdeněk POSPÍŠIL (203 Czech Republic, belonging to the institution), Lucie MARTYKÁNOVÁ (203 Czech Republic, belonging to the institution), Katerina HORTOVA (203 Czech Republic), Lucie MANDELOVA (203 Czech Republic), Karel HEJDUK (203 Czech Republic, belonging to the institution), Renata CHLOUPKOVÁ (203 Czech Republic, belonging to the institution), Michal POSPÍŠIL (203 Czech Republic, belonging to the institution), Martina DOUBKOVÁ (203 Czech Republic, belonging to the institution), Vladimír MAREK (203 Czech Republic, belonging to the institution), Renata NOVOTNA (203 Czech Republic), Martin DOLEČEK (203 Czech Republic, belonging to the institution), Hana MATĚJOVSKÁ KUBEŠOVÁ (203 Czech Republic, belonging to the institution), Kristián BRAT (703 Slovakia, belonging to the institution), Radana PAŘÍZKOVÁ (203 Czech Republic, belonging to the institution), Petr HUSA (203 Czech Republic, belonging to the institution), Marek MECHL (203 Czech Republic, belonging to the institution), Zdeněk KRÁL (203 Czech Republic, belonging to the institution) and Martina LENGEROVÁ (203 Czech Republic, belonging to the institution)
Edition
Nature Scientific Reports, London, NATURE RESEARCH, 2021, 2045-2322
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10700 1.7 Other natural sciences
Country of publisher
Germany
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.996
RIV identification code
RIV/00216224:14110/21:00121827
Organization unit
Faculty of Medicine
UT WoS
000652603700004
Keywords in English
COVID-19; ambulatory monitored outpatients
Tags
International impact, Reviewed
Změněno: 5/4/2022 13:35, Mgr. Tereza Miškechová
Abstract
V originále
Research objective was to detail COVID-19's natural trajectory in relation to the Czech population's viral load. Our prospective detailed daily questionnaire-based telemonitoring study evaluated COVID-19's impact among 105 outpatients. In accordance with government quarantine requirements, outpatients were divided into a cohort with two negative tests at the end of the disease (40 patients) and a cohort with a new algorithm (65 patients) following a 14-day quarantine. Median follow-up differed significantly between the 2 groups (23 days vs. 16 days). Only 6% of patients were asymptomatic during the entire telemonitoring period. Another 13% of patients were diagnosed asymptomatic, as suspected contacts, yet later developed symptoms, while the remaining 81% were diagnosed as symptomatic on average 6 days following symptom onset. Telemonitoring enabled precise symptom status chronicling. The most frequently reported complaints were fevers, respiratory issues, and anosmia. Six patients were eventually hospitalized for complications detected early after routine telemonitoring. During the extended follow-up (median 181 days), anosmia persisted in 26% of patients. 79% of patients in the new quarantine algorithm cohort reported no symptoms on day 11 compared to just 56% of patients in the two negative test cohort upon first testing negative (median-19 days). The highest viral load occurred within 0-2 days of initial symptom onset. Both the PCR viral load and two consecutive PCR negative sample realizations indicated high interindividual variability with a surprisingly fluctuating pattern among 43% of patients. No definitive COVID-19 symptoms or set of symptoms excepting anosmia (59%) and/or ageusia (47%) were identified. No preexisting medical conditions specifically foreshadowed disease trajectory in a given patient. Without a PCR negativity requirement for quarantine cessation, patients could exhibit fewer symptoms. Our study therefore highlights the urgent need for routine ambulatory patient telemedicine monitoring, early complication detection, intensive mass education connecting disease demeanor with subsequent swift diagnostics, and, notably, the need to reevaluate and modify quarantine regulations for better control of SARS-CoV-2 proliferation.