Polyscore of autonomic parameters for risk stratification of
the elderly general population: the Polyscore study

J 2021

Polyscore of autonomic parameters for risk stratification of the elderly general population: the Polyscore study

STEGER, Alexander, Michael DOMMASCH, Alexander MULLER, Daniel SINNECKER, Katharina M. HUSTER et. al.

Basic information

Original name

Polyscore of autonomic parameters for risk stratification of the elderly general population: the Polyscore study

Authors

STEGER, Alexander, Michael DOMMASCH, Alexander MULLER, Daniel SINNECKER, Katharina M. HUSTER, Teresa GOTZLER, Othmar GOTZLER, Alexander HAPFELMEIER, Kurt ULM, Petra BARTHEL, Katerina HNATKOVA (203 Czech Republic), Karl-Ludwig LAUGWITZ, Marek MALÍK (203 Czech Republic, belonging to the institution) and Georg SCHMIDT

Edition

Europace, Oxford, Oxford University Press, 2021, 1099-5129

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.486

RIV identification code

RIV/00216224:14110/21:00121829

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1093/europace/euaa359

UT WoS

000657483300019

Keywords in English

Elderly general population; Prospective validation; Autonomic markers; Risk assessment; Polyscore

Abstract

V originále

Aims Present society is constantly ageing and elderly frequently suffer from conditions that are difficult and/or costly to treat if detected late. Effective screening of the elderly is therefore needed so that those requiring detailed clinical work-up are identified early. We present a prospective validation of a screening strategy based on a Polyscore of seven predominantly autonomic, non-invasive risk markers. Methods and results Within a population-based survey in Germany (INVADE study), participants aged >= 60 years were enrolled between August 2013 and February 2015. Seven prospectively defined Polyscore components were obtained during 30-min continuous recordings of electrocardiogram, blood pressure, and respiration. Out of 1956 subjects, 168 were excluded due to atrial fibrillation, implanted pacemaker, or unsuitable recordings. All-cause mortality over a median 4-year follow-up was prospectively defined as the primary endpoint. The Polyscore divided the investigated population (n= 1788, median age: 72 years, females: 58%) into three predefined groups with low (n= 1405, 78.6%), intermediate (n = 326, 18.2%), and high risk (n = 57, 3.2%). During the follow-up, 82 (4.6%) participants died. Mortality in the Polyscore-defined risk groups was 3.4%, 7.4%, and 17.5%, respectively (P <0.0001). The Polyscore-based mortality prediction was independent of Framingham score, diabetes, chronic kidney disease, and major stroke and/or myocardial infarction history. It was particularly effective in those aged <75 years (n = 1145). Conclusion The Polyscore-based mortality risk assessment from short-term non-invasive recordings is effective in the elderly general population, especially those aged 60-74 years. Implementation of a comprehensive Polyscore screening of this age group is proposed to advance preventive medical care.

Citovat

STEGER, Alexander, Michael DOMMASCH, Alexander MULLER, Daniel SINNECKER, Katharina M. HUSTER, Teresa GOTZLER, Othmar GOTZLER, Alexander HAPFELMEIER, Kurt ULM, Petra BARTHEL, Katerina HNATKOVA, Karl-Ludwig LAUGWITZ, Marek MALÍK and Georg SCHMIDT. Polyscore of autonomic parameters for risk stratification of the elderly general population: the Polyscore study. Europace. Oxford: Oxford University Press, 2021, vol. 23, No 5, p. 789-796. ISSN 1099-5129. Available from: https://dx.doi.org/10.1093/europace/euaa359.

@article{1778201,
   author = {Steger, Alexander and Dommasch, Michael and Muller, Alexander and Sinnecker, Daniel and Huster, Katharina M. and Gotzler, Teresa and Gotzler, Othmar and Hapfelmeier, Alexander and Ulm, Kurt and Barthel, Petra and Hnatkova, Katerina and Laugwitz, KarlandLudwig and Malík, Marek and Schmidt, Georg},
   article_location = {Oxford},
   article_number = {5},
   doi = {http://dx.doi.org/10.1093/europace/euaa359},
   keywords = {Elderly general population; Prospective validation; Autonomic markers; Risk assessment; Polyscore},
   language = {eng},
   issn = {1099-5129},
   journal = {Europace},
   title = {Polyscore of autonomic parameters for risk stratification of the elderly general population: the Polyscore study},
   url = {https://www.sciencedirect.com/science/article/pii/S0278584620304814?via%3Dihub},
   volume = {23},
   year = {2021}
}

TY  - JOUR
ID  - 1778201
AU  - Steger, Alexander - Dommasch, Michael - Muller, Alexander - Sinnecker, Daniel - Huster, Katharina M. - Gotzler, Teresa - Gotzler, Othmar - Hapfelmeier, Alexander - Ulm, Kurt - Barthel, Petra - Hnatkova, Katerina - Laugwitz, Karl-Ludwig - Malík, Marek - Schmidt, Georg
PY  - 2021
TI  - Polyscore of autonomic parameters for risk stratification of the elderly general population: the Polyscore study
JF  - Europace
VL  - 23
IS  - 5
SP  - 789-796
EP  - 789-796
PB  - Oxford University Press
SN  - 10995129
KW  - Elderly general population
KW  - Prospective validation
KW  - Autonomic markers
KW  - Risk assessment
KW  - Polyscore
UR  - https://www.sciencedirect.com/science/article/pii/S0278584620304814?via%3Dihub
N2  - Aims Present society is constantly ageing and elderly frequently suffer from conditions that are difficult and/or costly to treat if detected late. Effective screening of the elderly is therefore needed so that those requiring detailed clinical work-up are identified early. We present a prospective validation of a screening strategy based on a Polyscore of seven predominantly autonomic, non-invasive risk markers. Methods and results Within a population-based survey in Germany (INVADE study), participants aged >= 60 years were enrolled between August 2013 and February 2015. Seven prospectively defined Polyscore components were obtained during 30-min continuous recordings of electrocardiogram, blood pressure, and respiration. Out of 1956 subjects, 168 were excluded due to atrial fibrillation, implanted pacemaker, or unsuitable recordings. All-cause mortality over a median 4-year follow-up was prospectively defined as the primary endpoint. The Polyscore divided the investigated population (n= 1788, median age: 72 years, females: 58%) into three predefined groups with low (n= 1405, 78.6%), intermediate (n = 326, 18.2%), and high risk (n = 57, 3.2%). During the follow-up, 82 (4.6%) participants died. Mortality in the Polyscore-defined risk groups was 3.4%, 7.4%, and 17.5%, respectively (P <0.0001). The Polyscore-based mortality prediction was independent of Framingham score, diabetes, chronic kidney disease, and major stroke and/or myocardial infarction history. It was particularly effective in those aged <75 years (n = 1145). Conclusion The Polyscore-based mortality risk assessment from short-term non-invasive recordings is effective in the elderly general population, especially those aged 60-74 years. Implementation of a comprehensive Polyscore screening of this age group is proposed to advance preventive medical care.
ER  -

STEGER, Alexander, Michael DOMMASCH, Alexander MULLER, Daniel SINNECKER, Katharina M. HUSTER, Teresa GOTZLER, Othmar GOTZLER, Alexander HAPFELMEIER, Kurt ULM, Petra BARTHEL, Katerina HNATKOVA, Karl-Ludwig LAUGWITZ, Marek MALÍK and Georg SCHMIDT. Polyscore of autonomic parameters for risk stratification of the elderly general population: the Polyscore study. \textit{Europace}. Oxford: Oxford University Press, 2021, vol.~23, No~5, p.~789-796. ISSN~1099-5129. Available from: https://dx.doi.org/10.1093/europace/euaa359.

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