Thermal Ablation and Transarterial Chemoembolization are
Characterized by Changing Dynamics of Circulating MicroRNAs

J 2021

Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs

ANDRAŠINA, Tomáš, Jaroslav JURÁČEK, Jan ZAVADIL, Barbora ČECHOVÁ, Tomáš ROHAN et. al.

Basic information

Original name

Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs

Authors

ANDRAŠINA, Tomáš (703 Slovakia, guarantor, belonging to the institution), Jaroslav JURÁČEK (203 Czech Republic, belonging to the institution), Jan ZAVADIL (203 Czech Republic, belonging to the institution), Barbora ČECHOVÁ (203 Czech Republic, belonging to the institution), Tomáš ROHAN (203 Czech Republic, belonging to the institution), Petra VESELÁ (203 Czech Republic, belonging to the institution), Mor PALDOR, Ondřej SLABÝ (203 Czech Republic, belonging to the institution) and Nahum GOLDBERG

Edition

Journal of vascular and interventional radiology, New York, Lippincott Williams & Wilkins, 2021, 1051-0443

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30224 Radiology, nuclear medicine and medical imaging

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.682

RIV identification code

RIV/00216224:14110/21:00121875

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.jvir.2020.10.024

UT WoS

000645600200011

Keywords in English

EPITHELIAL-MESENCHYMAL TRANSITION; RADIOFREQUENCY ABLATION; HEPATOCELLULAR-CARCINOMA; SERUM MICRORNA-210; CANCER; EXPRESSION; MECHANISM; GROWTH; PROGRESSION; METASTASIS

Abstract

V originále

Purpose: To determine whether the levels of circulating microRNAs (miRNAs) are altered in patients undergoing thermal ablation and chemoembolization and whether these changes are predictive of a clinical outcome. Material and Methods: This prospective study consisted of 43 patients diagnosed with hepatocellular carcinoma (n = 15) and intrahepatic colorectal cancer metastases (n = 28) treated with thermal ablation (n = 23; radiofrequency [n = 6] or microwave [n = 19]), chemoembolization using drug-eluting embolics (n = 18), or both (n = 2). Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. Tumor burden and treatment response at 3 months were evaluated using the modified response evaluation criteria in solid tumors. The miRNA results were compared with clinical outcomes (Mann-Whitney U test, Wilcoxon matched-pair test). Results: Dynamic changes in the circulating miRNA levels were observed following both the interventions. For thermal ablation, significant increases in miR-21, miR-210, miR-122, miR-200a, and miR-34a concentrations peaked 60-90 minutes after the intervention (P < .01). However, for transarterial chemoembolization, maximum increases in the miRNA concentrations were observed at 24 hours after the intervention for miR-21, miR-210, miR-122, miR-200a, and miR-34a (P < .05). The increased concentrations of the circulating miRNAs were followed by a subsequent decline to baseline by 7 days. For the thermal ablation (but not chemoembolization) patients, elevations in the miR-210 and miR-200a levels were associated with early progressive disease at 3 months (P = .040 and P = .012, respectively). Conclusions: Increased but dynamic levels of circulating miRNAs are present following interventional oncologic procedures and may prove useful as biomarkers for the monitoring of clinical outcomes.

Links

MUNI/A/1488/2019, interní kód MU

Name: Význam radiologických intervencí a pokročilých zobrazovacích metod v diagnostice a léčbě onkologických pacientů

Investor: Masaryk University, Category A

Citovat

ANDRAŠINA, Tomáš, Jaroslav JURÁČEK, Jan ZAVADIL, Barbora ČECHOVÁ, Tomáš ROHAN, Petra VESELÁ, Mor PALDOR, Ondřej SLABÝ and Nahum GOLDBERG. Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs. Journal of vascular and interventional radiology. New York: Lippincott Williams & Wilkins, 2021, vol. 32, No 3, p. 403-411. ISSN 1051-0443. Available from: https://dx.doi.org/10.1016/j.jvir.2020.10.024.

@article{1780439,
   author = {Andrašina, Tomáš and Juráček, Jaroslav and Zavadil, Jan and Čechová, Barbora and Rohan, Tomáš and Veselá, Petra and Paldor, Mor and Slabý, Ondřej and Goldberg, Nahum},
   article_location = {New York},
   article_number = {3},
   doi = {http://dx.doi.org/10.1016/j.jvir.2020.10.024},
   keywords = {EPITHELIAL-MESENCHYMAL TRANSITION; RADIOFREQUENCY ABLATION; HEPATOCELLULAR-CARCINOMA; SERUM MICRORNA-210; CANCER; EXPRESSION; MECHANISM; GROWTH; PROGRESSION; METASTASIS},
   language = {eng},
   issn = {1051-0443},
   journal = {Journal of vascular and interventional radiology},
   title = {Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs},
   url = {https://www.sciencedirect.com/science/article/pii/S1051044320309532},
   volume = {32},
   year = {2021}
}

TY  - JOUR
ID  - 1780439
AU  - Andrašina, Tomáš - Juráček, Jaroslav - Zavadil, Jan - Čechová, Barbora - Rohan, Tomáš - Veselá, Petra - Paldor, Mor - Slabý, Ondřej - Goldberg, Nahum
PY  - 2021
TI  - Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs
JF  - Journal of vascular and interventional radiology
VL  - 32
IS  - 3
SP  - 403-411
EP  - 403-411
PB  - Lippincott Williams & Wilkins
SN  - 10510443
KW  - EPITHELIAL-MESENCHYMAL TRANSITION
KW  - RADIOFREQUENCY ABLATION
KW  - HEPATOCELLULAR-CARCINOMA
KW  - SERUM MICRORNA-210
KW  - CANCER
KW  - EXPRESSION
KW  - MECHANISM
KW  - GROWTH
KW  - PROGRESSION
KW  - METASTASIS
UR  - https://www.sciencedirect.com/science/article/pii/S1051044320309532
N2  - Purpose: To determine whether the levels of circulating microRNAs (miRNAs) are altered in patients undergoing thermal ablation and chemoembolization and whether these changes are predictive of a clinical outcome. Material and Methods: This prospective study consisted of 43 patients diagnosed with hepatocellular carcinoma (n = 15) and intrahepatic colorectal cancer metastases (n = 28) treated with thermal ablation (n = 23; radiofrequency [n = 6] or microwave [n = 19]), chemoembolization using drug-eluting embolics (n = 18), or both (n = 2). Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. Tumor burden and treatment response at 3 months were evaluated using the modified response evaluation criteria in solid tumors. The miRNA results were compared with clinical outcomes (Mann-Whitney U test, Wilcoxon matched-pair test). Results: Dynamic changes in the circulating miRNA levels were observed following both the interventions. For thermal ablation, significant increases in miR-21, miR-210, miR-122, miR-200a, and miR-34a concentrations peaked 60-90 minutes after the intervention (P < .01). However, for transarterial chemoembolization, maximum increases in the miRNA concentrations were observed at 24 hours after the intervention for miR-21, miR-210, miR-122, miR-200a, and miR-34a (P < .05). The increased concentrations of the circulating miRNAs were followed by a subsequent decline to baseline by 7 days. For the thermal ablation (but not chemoembolization) patients, elevations in the miR-210 and miR-200a levels were associated with early progressive disease at 3 months (P = .040 and P = .012, respectively). Conclusions: Increased but dynamic levels of circulating miRNAs are present following interventional oncologic procedures and may prove useful as biomarkers for the monitoring of clinical outcomes.
ER  -

ANDRAŠINA, Tomáš, Jaroslav JURÁČEK, Jan ZAVADIL, Barbora ČECHOVÁ, Tomáš ROHAN, Petra VESELÁ, Mor PALDOR, Ondřej SLABÝ and Nahum GOLDBERG. Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs. \textit{Journal of vascular and interventional radiology}. New York: Lippincott Williams \&{} Wilkins, 2021, vol.~32, No~3, p.~403-411. ISSN~1051-0443. Available from: https://dx.doi.org/10.1016/j.jvir.2020.10.024.

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