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@article{1780443, author = {Psár, Robert and Urban, Ondřej and Černá, Marie and Rohan, Tomáš and Hill, Martin}, article_location = {Švýcarsko}, article_number = {5}, doi = {http://dx.doi.org/10.3390/diagnostics11050776}, keywords = {computed tomography; early diagnosis; endoscopic ultrasound-guided fine needle aspiration; isoattenuation; pancreatic carcinoma}, language = {eng}, issn = {2075-4418}, journal = {Diagnostics}, title = {Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA)}, url = {https://www.mdpi.com/2075-4418/11/5/776/htm}, volume = {11}, year = {2021} }
TY - JOUR ID - 1780443 AU - Psár, Robert - Urban, Ondřej - Černá, Marie - Rohan, Tomáš - Hill, Martin PY - 2021 TI - Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA) JF - Diagnostics VL - 11 IS - 5 SP - 1-11 EP - 1-11 PB - MDPI SN - 20754418 KW - computed tomography KW - early diagnosis KW - endoscopic ultrasound-guided fine needle aspiration KW - isoattenuation KW - pancreatic carcinoma UR - https://www.mdpi.com/2075-4418/11/5/776/htm N2 - (1) Background. The aim was to define typical features of isoattenuating pancreatic carcinomas on computed tomography (CT) and endosonography and determine the yield of fine-needle aspiration endosonography (EUS-FNA) in their diagnosis. (2) Methods. One hundred and seventy-three patients with pancreatic carcinomas underwent multiphase contrast-enhanced CT followed by EUS-FNA at the time of diagnosis. Secondary signs on CT, size and location on EUS, and the yield of EUS-FNA in isoattenuating and hypoattenuating pancreatic cancer, were evaluated. (3) Results. Isoattenuating pancreatic carcinomas occurred in 12.1% of patients. Secondary signs of isoattenuating pancreatic carcinomas on CT were present in 95.2% cases and included dilatation of the pancreatic duct and/or the common bile duct (85.7%), interruption of the pancreatic duct (76.2%), abnormal pancreatic contour (33.3%), and atrophy of the distal parenchyma (9.5%) Compared to hypoattenuating pancreatic carcinomas, isoattenuating carcinomas were more often localized in the pancreatic head (100% vs. 59.2%; p < 0.001). In ROC (receiver operating characteristic) analysis, the optimal cut-off value for the size of isoattenuating carcinomas on EUS was <= 25 mm (AUC = 0.898). The sensitivity of EUS-FNA in confirmation of isoattenuating and hypoattenuating pancreatic cancer were 90.5% and 92.8% (p = 0.886). (4) Conclusions. Isoattenuating pancreatic head carcinoma can be revealed by indirect signs on CT and confirmed with high sensitivity by EUS-FNA. ER -
PSÁR, Robert, Ondřej URBAN, Marie ČERNÁ, Tomáš ROHAN and Martin HILL. Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA). \textit{Diagnostics}. Švýcarsko: MDPI, 2021, vol.~11, No~5, p.~1-11. ISSN~2075-4418. Available from: https://dx.doi.org/10.3390/diagnostics11050776.
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