| KUBÍNOVÁ, Renata, R. PORIZKOVA, Alice SYCHROVÁ, Oldřich FARSA, Zuzana HANÁKOVÁ, A. BACINSKA, Alois ČÍŽEK and Marie VALENTOVÁ. Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth. Journal of Enzyme Inhibition and Medicinal Chemistry. UK: Taylor & Francis, 2014, vol. 29, No 5, p. 749-752. ISSN 1475-6366. Available from: https://dx.doi.org/10.3109/14756366.2013.848204. |
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@article{1781680,
author = {Kubínová, Renata and Porizkova, R. and Sychrová, Alice and Farsa, Oldřich and Hanáková, Zuzana and Bacinska, A. and Čížek, Alois and Valentová, Marie},
article_location = {UK},
article_number = {5},
doi = {http://dx.doi.org/10.3109/14756366.2013.848204},
keywords = {alpha-glucosidase; antibacterial activity; cholinesterase; diterpenoids; rosmarinic acid},
language = {eng},
issn = {1475-6366},
journal = {Journal of Enzyme Inhibition and Medicinal Chemistry},
title = {Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth},
url = {https://pubmed.ncbi.nlm.nih.gov/24506206/},
volume = {29},
year = {2014}
}
TY - JOUR
ID - 1781680
AU - Kubínová, Renata - Porizkova, R. - Sychrová, Alice - Farsa, Oldřich - Hanáková, Zuzana - Bacinska, A. - Čížek, Alois - Valentová, Marie
PY - 2014
TI - Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth
JF - Journal of Enzyme Inhibition and Medicinal Chemistry
VL - 29
IS - 5
SP - 749-752
EP - 749-752
PB - Taylor & Francis
SN - 14756366
KW - alpha-glucosidase
KW - antibacterial activity
KW - cholinesterase
KW - diterpenoids
KW - rosmarinic acid
UR - https://pubmed.ncbi.nlm.nih.gov/24506206/
N2 - Plectranthus madagascariensis is used as a traditional medicine in Southern Africa. In search of compounds and activities supporting the medicinal use, the chemical profile of the methanolic extract was studied by high-performance liquid chromatography with diode array detection (HPLC-DAD). Four major constituents were isolated and identified as rosmarinic acid (1), 7 beta, 6 beta-dihydroxyroyleanone (2), 7 beta-acetoxy-6 beta-hydroxyroyleanone (3) and coleon U quinone (4). The two abietane diterpenoids (2 and 3) were isolated for the first time from this species. Antimicrobial, cholinesterase and alpha-glucosidase inhibitory activities of these compounds were studied. The compounds exhibited inhibitory activity on alpha-glucosidase with IC50 values from 33 to 275 mu M. Abietanes showed potent antibacterial activity against Staphylococcus aureus and Enterococcus faecalis.
ER -
KUBÍNOVÁ, Renata, R. PORIZKOVA, Alice SYCHROVÁ, Oldřich FARSA, Zuzana HANÁKOVÁ, A. BACINSKA, Alois ČÍŽEK and Marie VALENTOVÁ. Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth. \textit{Journal of Enzyme Inhibition and Medicinal Chemistry}. UK: Taylor \&{} Francis, 2014, vol.~29, No~5, p.~749-752. ISSN~1475-6366. Available from: https://dx.doi.org/10.3109/14756366.2013.848204.
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