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@article{1781684,
author = {Sychrová, Alice and Schneiderova, K. and Vesela, D. and Hanáková, Zuzana and Fontana, A. and Dall, Acqua S. and Cvacka, J. and Innocenti, G. and Novotna, J. and Urbanova, M. and Pelletier, J. and Čížek, Alois and Zemlickova, H. and Šmejkal, Karel},
article_location = {Oxford},
doi = {http://dx.doi.org/10.1016/j.phytochem.2013.01.002},
keywords = {Paulownia tomentosa; Preparative HPLC; Prenyl; Geranyl; Flavonoid; MRSA; Antibacterial},
language = {eng},
issn = {0031-9422},
journal = {Phytochemistry},
title = {Minor C-geranylated flavanones from Paulownia tomentosa fruits with MRSA antibacterial activity},
url = {https://www.sciencedirect.com/science/article/pii/S0031942213000241?via%3Dihub},
volume = {89},
year = {2013}
}
TY - JOUR
ID - 1781684
AU - Sychrová, Alice - Schneiderova, K. - Vesela, D. - Hanáková, Zuzana - Fontana, A. - Dall, Acqua S. - Cvacka, J. - Innocenti, G. - Novotna, J. - Urbanova, M. - Pelletier, J. - Čížek, Alois - Zemlickova, H. - Šmejkal, Karel
PY - 2013
TI - Minor C-geranylated flavanones from Paulownia tomentosa fruits with MRSA antibacterial activity
JF - Phytochemistry
VL - 89
SP - 104-113
EP - 104-113
PB - Pergamon-Elsevier Science LTD
SN - 00319422
KW - Paulownia tomentosa
KW - Preparative HPLC
KW - Prenyl
KW - Geranyl
KW - Flavonoid
KW - MRSA
KW - Antibacterial
UR - https://www.sciencedirect.com/science/article/pii/S0031942213000241?via%3Dihub
N2 - Exhaustive chromatographic separation of the chloroform portion of the ethanolic extract obtained from Paulownia tomentosa (Thunb). Steud. (Paulowniaceae) fruits has led to isolation of ten C-6 geranylated flavanones tomentodiplacone C-I and mimulone C-E, featured by 3'-methoxy and 4'-hydroxy or 4'-hydroxy substitution of the B-ring of the flavonoid, respectively. The structures of these compounds were determined by using mass spectrometry (including HRMS) and 1D and 2D NMR spectroscopy. The absolute configurations of the compounds at C-2 were determined using circular dichroism. The obtained compounds showed the presence of a geranyl moiety functionalized by a carbonyl, hydroxyl or methoxyl group, or by formation of tetrahydrofuran or fused-pyrane ring, respectively. All of the flavanones described were isolated for the first time from a natural source. The antibacterial activities of selected compounds isolated along with the previously isolated geranylated flavanones were evaluated against a common panel of microbes and MRSA strains. The selected isolated compounds were tested for their ability to affect eukaryotic translation initiation via dual-luciferase reporter assay (firefly and renilla). (C) 2013 Elsevier Ltd. All rights reserved.
ER -
SYCHROVÁ, Alice, K. SCHNEIDEROVA, D. VESELA, Zuzana HANÁKOVÁ, A. FONTANA, Acqua S. DALL, J. CVACKA, G. INNOCENTI, J. NOVOTNA, M. URBANOVA, J. PELLETIER, Alois ČÍŽEK, H. ZEMLICKOVA a Karel ŠMEJKAL. Minor C-geranylated flavanones from Paulownia tomentosa fruits with MRSA antibacterial activity. \textit{Phytochemistry}. Oxford: Pergamon-Elsevier Science LTD, roč.~89, s.~104-113. ISSN~0031-9422. doi:10.1016/j.phytochem.2013.01.002. 2013.
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