SYCHROVÁ, Alice, K. SCHNEIDEROVA, D. VESELA, Zuzana HANÁKOVÁ, A. FONTANA, Acqua S. DALL, J. CVACKA, G. INNOCENTI, J. NOVOTNA, M. URBANOVA, J. PELLETIER, Alois ČÍŽEK, H. ZEMLICKOVA and Karel ŠMEJKAL. Minor C-geranylated flavanones from Paulownia tomentosa fruits with MRSA antibacterial activity. Phytochemistry. Oxford: Pergamon-Elsevier Science LTD, 2013, vol. 89, p. 104-113. ISSN 0031-9422. Available from: https://dx.doi.org/10.1016/j.phytochem.2013.01.002.
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Basic information
Original name Minor C-geranylated flavanones from Paulownia tomentosa fruits with MRSA antibacterial activity
Authors SYCHROVÁ, Alice, K. SCHNEIDEROVA, D. VESELA, Zuzana HANÁKOVÁ, A. FONTANA, Acqua S. DALL, J. CVACKA, G. INNOCENTI, J. NOVOTNA, M. URBANOVA, J. PELLETIER, Alois ČÍŽEK, H. ZEMLICKOVA and Karel ŠMEJKAL.
Edition Phytochemistry, Oxford, Pergamon-Elsevier Science LTD, 2013, 0031-9422.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.350
Organization unit Faculty of Pharmacy
Doi http://dx.doi.org/10.1016/j.phytochem.2013.01.002
UT WoS 000318133800013
Keywords in English Paulownia tomentosa; Preparative HPLC; Prenyl; Geranyl; Flavonoid; MRSA; Antibacterial
Tags International impact, Reviewed
Changed by Changed by: Mgr. Hana Hurtová, učo 244985. Changed: 12/7/2021 08:40.
Abstract
Exhaustive chromatographic separation of the chloroform portion of the ethanolic extract obtained from Paulownia tomentosa (Thunb). Steud. (Paulowniaceae) fruits has led to isolation of ten C-6 geranylated flavanones tomentodiplacone C-I and mimulone C-E, featured by 3'-methoxy and 4'-hydroxy or 4'-hydroxy substitution of the B-ring of the flavonoid, respectively. The structures of these compounds were determined by using mass spectrometry (including HRMS) and 1D and 2D NMR spectroscopy. The absolute configurations of the compounds at C-2 were determined using circular dichroism. The obtained compounds showed the presence of a geranyl moiety functionalized by a carbonyl, hydroxyl or methoxyl group, or by formation of tetrahydrofuran or fused-pyrane ring, respectively. All of the flavanones described were isolated for the first time from a natural source. The antibacterial activities of selected compounds isolated along with the previously isolated geranylated flavanones were evaluated against a common panel of microbes and MRSA strains. The selected isolated compounds were tested for their ability to affect eukaryotic translation initiation via dual-luciferase reporter assay (firefly and renilla). (C) 2013 Elsevier Ltd. All rights reserved.
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