Immunosenescence in Childhood Cancer Survivors and in Elderly:
A Comparison and Implication for Risk Stratification

J 2021

Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification

LÁZNIČKOVÁ, Petra, Kamila BENDÍČKOVÁ, Tomáš KEPÁK and Jan FRIČ

Basic information

Original name

Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification

Authors

LÁZNIČKOVÁ, Petra (203 Czech Republic, belonging to the institution), Kamila BENDÍČKOVÁ (203 Czech Republic), Tomáš KEPÁK (203 Czech Republic, belonging to the institution) and Jan FRIČ (203 Czech Republic, guarantor)

Edition

Frontiers in Aging, LAUSANNE, FRONTIERS MEDIA SA, 2021, 1663-4365

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.702

RIV identification code

RIV/00216224:14110/21:00121956

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3389/fragi.2021.708788

UT WoS

001090275600001

Keywords in English

childhood cancer survivor; immunosenescence; low-grade inflammation; accelerated aging; late effects; patient stratification; elderly

Abstract

V originále

The population of childhood cancer survivors (CCS) has grown rapidly in recent decades. Although cured of their original malignancy, these individuals are at increased risk of serious late effects, including age-associated complications. An impaired immune system has been linked to the emergence of these conditions in the elderly and CCS, likely due to senescent immune cell phenotypes accompanied by low-grade inflammation, which in the elderly is known as “inflammaging.” Whether these observations in the elderly and CCS are underpinned by similar mechanisms is unclear. If so, existing knowledge on immunosenescent phenotypes and inflammaging might potentially serve to benefit CCS. We summarize recent findings on the immune changes in CCS and the elderly, and highlight the similarities and identify areas for future research. Improving our understanding of the underlying mechanisms and immunosenescent markers of accelerated immune aging might help us to identify individuals at increased risk of serious health complications.

Links

MUNI/A/1325/2020, interní kód MU

Name: Biomedicínské vědy

Investor: Masaryk University

Citovat

LÁZNIČKOVÁ, Petra, Kamila BENDÍČKOVÁ, Tomáš KEPÁK and Jan FRIČ. Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification. Frontiers in Aging. LAUSANNE: FRONTIERS MEDIA SA, 2021, vol. 2021, No 2, p. 1-20. ISSN 1663-4365. Available from: https://dx.doi.org/10.3389/fragi.2021.708788.

@article{1783117,
   author = {Lázničková, Petra and Bendíčková, Kamila and Kepák, Tomáš and Frič, Jan},
   article_location = {LAUSANNE},
   article_number = {2},
   doi = {http://dx.doi.org/10.3389/fragi.2021.708788},
   keywords = {childhood cancer survivor; immunosenescence; low-grade inflammation; accelerated aging; late effects; patient stratification; elderly},
   language = {eng},
   issn = {1663-4365},
   journal = {Frontiers in Aging},
   title = {Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification},
   url = {https://www.frontiersin.org/articles/10.3389/fragi.2021.708788/full#h9},
   volume = {2021},
   year = {2021}
}

TY  - JOUR
ID  - 1783117
AU  - Lázničková, Petra - Bendíčková, Kamila - Kepák, Tomáš - Frič, Jan
PY  - 2021
TI  - Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification
JF  - Frontiers in Aging
VL  - 2021
IS  - 2
SP  - 1-20
EP  - 1-20
PB  - FRONTIERS MEDIA SA
SN  - 16634365
KW  - childhood cancer survivor
KW  - immunosenescence
KW  - low-grade inflammation
KW  - accelerated aging
KW  - late effects
KW  - patient stratification
KW  - elderly
UR  - https://www.frontiersin.org/articles/10.3389/fragi.2021.708788/full#h9
N2  - The population of childhood cancer survivors (CCS) has grown rapidly in recent decades. Although cured of their original malignancy, these individuals are at increased risk of serious late effects, including age-associated complications. An impaired immune system has been linked to the emergence of these conditions in the elderly and CCS, likely due to senescent immune cell phenotypes accompanied by low-grade inflammation, which in the elderly is known as “inflammaging.” Whether these observations in the elderly and CCS are underpinned by similar mechanisms is unclear. If so, existing knowledge on immunosenescent phenotypes and inflammaging might potentially serve to benefit CCS. We summarize recent findings on the immune changes in CCS and the elderly, and highlight the similarities and identify areas for future research. Improving our understanding of the underlying mechanisms and immunosenescent markers of accelerated immune aging might help us to identify individuals at increased risk of serious health complications.
ER  -

LÁZNIČKOVÁ, Petra, Kamila BENDÍČKOVÁ, Tomáš KEPÁK and Jan FRIČ. Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification. \textit{Frontiers in Aging}. LAUSANNE: FRONTIERS MEDIA SA, 2021, vol.~2021, No~2, p.~1-20. ISSN~1663-4365. Available from: https://dx.doi.org/10.3389/fragi.2021.708788.

Detailed Information on Publication Record