Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification

LÁZNIČKOVÁ, Petra, Kamila BENDÍČKOVÁ, Tomáš KEPÁK and Jan FRIČ. Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification. Frontiers in Aging. LAUSANNE: FRONTIERS MEDIA SA, 2021, vol. 2021, No 2, p. 1-20. ISSN 1663-4365. Available from: https://dx.doi.org/10.3389/fragi.2021.708788.

Basic information

• Original name: Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification
• Authors: LÁZNIČKOVÁ, Petra (203 Czech Republic, belonging to the institution), Kamila BENDÍČKOVÁ (203 Czech Republic), Tomáš KEPÁK (203 Czech Republic, belonging to the institution) and Jan FRIČ (203 Czech Republic, guarantor).
• Edition: Frontiers in Aging, LAUSANNE, FRONTIERS MEDIA SA, 2021, 1663-4365.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30204 Oncology
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 5.702
• RIV identification code: RIV/00216224:14110/21:00121956
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.3389/fragi.2021.708788
• UT WoS: 001090275600001
• Keywords in English: childhood cancer survivor; immunosenescence; low-grade inflammation; accelerated aging; late effects; patient stratification; elderly
• Tags: 14110321, 14110513, rivok
• Tags: International impact, Reviewed

Abstract

The population of childhood cancer survivors (CCS) has grown rapidly in recent decades. Although cured of their original malignancy, these individuals are at increased risk of serious late effects, including age-associated complications. An impaired immune system has been linked to the emergence of these conditions in the elderly and CCS, likely due to senescent immune cell phenotypes accompanied by low-grade inflammation, which in the elderly is known as “inflammaging.” Whether these observations in the elderly and CCS are underpinned by similar mechanisms is unclear. If so, existing knowledge on immunosenescent phenotypes and inflammaging might potentially serve to benefit CCS. We summarize recent findings on the immune changes in CCS and the elderly, and highlight the similarities and identify areas for future research. Improving our understanding of the underlying mechanisms and immunosenescent markers of accelerated immune aging might help us to identify individuals at increased risk of serious health complications.

Links

• MUNI/A/1325/2020, interní kód MU: Name: Biomedicínské vědy

Investor: Masaryk University