| JAKUBIKOVA, Michala, Michaela TYBLOVA, Adam TESAR, Magda HORÁKOVÁ, Daniela VLAŽNÁ, Irena RYSANKOVA, Iveta NOVAKOVA, Kristyna DOLECKOVA, Pavel DUSEK, Jiri PITHA, Stanislav VOHÁŇKA and Josef BEDNAŘÍK. Predictive factors for a severe course of COVID-19 infection in myasthenia gravis patients with an overall impact on myasthenic outcome status and survival. European Journal of Neurology. Oxford: Rapid Science Ltd., 2021, vol. 28, No 10, p. 3418-3425. ISSN 1351-5101. Available from: https://dx.doi.org/10.1111/ene.14951. |
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@article{1783118,
author = {Jakubikova, Michala and Tyblova, Michaela and Tesar, Adam and Horáková, Magda and Vlažná, Daniela and Rysankova, Irena and Novakova, Iveta and Doleckova, Kristyna and Dusek, Pavel and Pitha, Jiri and Voháňka, Stanislav and Bednařík, Josef},
article_location = {Oxford},
article_number = {10},
doi = {http://dx.doi.org/10.1111/ene.14951},
keywords = {corticosteroids; COVID-19; immunosuppression; myasthenia gravis; rituximab},
language = {eng},
issn = {1351-5101},
journal = {European Journal of Neurology},
title = {Predictive factors for a severe course of COVID-19 infection in myasthenia gravis patients with an overall impact on myasthenic outcome status and survival},
url = {https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.14951},
volume = {28},
year = {2021}
}
TY - JOUR
ID - 1783118
AU - Jakubikova, Michala - Tyblova, Michaela - Tesar, Adam - Horáková, Magda - Vlažná, Daniela - Rysankova, Irena - Novakova, Iveta - Doleckova, Kristyna - Dusek, Pavel - Pitha, Jiri - Voháňka, Stanislav - Bednařík, Josef
PY - 2021
TI - Predictive factors for a severe course of COVID-19 infection in myasthenia gravis patients with an overall impact on myasthenic outcome status and survival
JF - European Journal of Neurology
VL - 28
IS - 10
SP - 3418-3425
EP - 3418-3425
PB - Rapid Science Ltd.
SN - 13515101
KW - corticosteroids
KW - COVID-19
KW - immunosuppression
KW - myasthenia gravis
KW - rituximab
UR - https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.14951
N2 - Background and purpose Myasthenia gravis (MG) patients could be a vulnerable group in the pandemic era of coronavirus 2019 (COVID-19) mainly due to respiratory muscle weakness, older age and long-term immunosuppressive treatment. We aimed to define factors predicting the severity of COVID-19 in MG patients and risk of MG exacerbation during COVID-19. Methods We evaluated clinical features and outcomes after COVID-19 in 93 MG patients. Results Thirty-five patients (38%) had severe pneumonia and we recorded 10 deaths (11%) due to COVID-19. Higher forced vital capacity (FVC) values tested before COVID-19 were shown to be protective against severe infection (95% CI 0.934-0.98) as well as good control of MG measured by the quantified myasthenia gravis score (95% CI 1.047-1.232). Long-term chronic corticosteroid treatment worsened the course of COVID-19 in MG patients (95% CI 1.784-111.43) and this impact was positively associated with dosage (p = 0.005). Treatment using azathioprine (95% CI 0.448-2.935), mycophenolate mofetil (95% CI 0.91-12.515) and ciclosporin (95% CI 0.029-2.212) did not influence the course of COVID-19. MG patients treated with rituximab had a high risk of death caused by COVID-19 (95% CI 3.216-383.971). Exacerbation of MG during infection was relatively rare (15%) and was not caused by remdesivir, convalescent plasma or favipiravir (95% CI 0.885-10.87). Conclusions As the most important predictors of severe COVID-19 in MG patients we identified unsatisfied condition of MG with lower FVC, previous long-term corticosteroid treatment especially in higher doses, older age, the presence of cancer, and recent rituximab treatment.
ER -
JAKUBIKOVA, Michala, Michaela TYBLOVA, Adam TESAR, Magda HORÁKOVÁ, Daniela VLAŽNÁ, Irena RYSANKOVA, Iveta NOVAKOVA, Kristyna DOLECKOVA, Pavel DUSEK, Jiri PITHA, Stanislav VOHÁŇKA and Josef BEDNAŘÍK. Predictive factors for a severe course of COVID-19 infection in myasthenia gravis patients with an overall impact on myasthenic outcome status and survival. \textit{European Journal of Neurology}. Oxford: Rapid Science Ltd., 2021, vol.~28, No~10, p.~3418-3425. ISSN~1351-5101. Available from: https://dx.doi.org/10.1111/ene.14951.
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