| KMOCHOVA, Klara, Tomas GREGA, Ondřej NGO, Gabriela VOJTECHOVA, Ondřej MÁJEK, Petr URBANEK, Miroslav ZAVORAL and Stepan SUCHANEK. Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study. Journal of Gastrointestinal and Liver Diseases. CLUJ-NAPOCA: MEDICAL UNIV PRESS, 2021, vol. 30, No 2, p. 213-220. ISSN 1841-8724. Available from: https://dx.doi.org/10.15403/jgld-3401. |
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@article{1783548,
author = {Kmochova, Klara and Grega, Tomas and Ngo, Ondřej and Vojtechova, Gabriela and Májek, Ondřej and Urbanek, Petr and Zavoral, Miroslav and Suchanek, Stepan},
article_location = {CLUJ-NAPOCA},
article_number = {2},
doi = {http://dx.doi.org/10.15403/jgld-3401},
keywords = {bowel preparation; cleansing agents; colonoscopy; quality of colonoscopy; screening; polyp detection rate},
language = {eng},
issn = {1841-8724},
journal = {Journal of Gastrointestinal and Liver Diseases},
title = {Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study},
url = {https://www.jgld.ro/jgld/index.php/jgld/article/view/3401},
volume = {30},
year = {2021}
}
TY - JOUR
ID - 1783548
AU - Kmochova, Klara - Grega, Tomas - Ngo, Ondřej - Vojtechova, Gabriela - Májek, Ondřej - Urbanek, Petr - Zavoral, Miroslav - Suchanek, Stepan
PY - 2021
TI - Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study
JF - Journal of Gastrointestinal and Liver Diseases
VL - 30
IS - 2
SP - 213-220
EP - 213-220
PB - MEDICAL UNIV PRESS
SN - 18418724
KW - bowel preparation
KW - cleansing agents
KW - colonoscopy
KW - quality of colonoscopy
KW - screening
KW - polyp detection rate
UR - https://www.jgld.ro/jgld/index.php/jgld/article/view/3401
N2 - Background & Aims: Adequate bowel preparation is essential for successful and effective colonoscopy. Several types of cleansing agents are currently available including low-volume solutions. The aim of this study was to compare the efficacy of four different bowel cleansing agents. Methods: A single-center, prospective, randomized, and single-blind study was performed. Consecutive patients referred for colonoscopy were enrolled and randomized into one of the following types of laxatives: polyethylenglycol 4L (PEG), oral sulfate solution (OSS), 2L polyethylenglycol + ascorbate (2L-PEG/Asc), or magnesium citrate + sodium picosulfate (MCSP). The primary outcome was quality of bowel cleansing evaluated according to the Boston Bowel Preparation Scale (BBPS). Secondary outcomes were polyp detection rate (PDR) and tolerability. Results: Final analysis was performed on 431 patients. The number of patients with adequate bowel preparation (BBPS total scores >= 6 and sub scores >= 2 in each segment) was not significantly different throughout all groups (95.4% PEG; 94.6% OSS; 96.3% 2L-PEG/Asc; 96.2% MCSP; p=0.955). Excellent bowel preparation (BBPS total scores >= 8) was associated with younger age (p=0.007). The groups did not have significantly different PDRs (49.5% PEG; 49.1% OSS; 38% 2L-PEG/Asc; 40.4% MCSP; p=0.201). The strongest predictors of pathology identification were age and male gender. The best-tolerated solution was MCSP (palatability: p<0.001; nausea: p=0.024). Conclusion: All tested laxatives provided comparable efficacy in terms of bowel cleansing quality and PDR. The low-volume agent MCSP was the best tolerated.
ER -
KMOCHOVA, Klara, Tomas GREGA, Ondřej NGO, Gabriela VOJTECHOVA, Ondřej MÁJEK, Petr URBANEK, Miroslav ZAVORAL and Stepan SUCHANEK. Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study. \textit{Journal of Gastrointestinal and Liver Diseases}. CLUJ-NAPOCA: MEDICAL UNIV PRESS, 2021, vol.~30, No~2, p.~213-220. ISSN~1841-8724. Available from: https://dx.doi.org/10.15403/jgld-3401.
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