J 2021

Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study

KMOCHOVA, Klara, Tomas GREGA, Ondřej NGO, Gabriela VOJTECHOVA, Ondřej MÁJEK et. al.

Basic information

Original name

Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study

Authors

KMOCHOVA, Klara (56 Belgium), Tomas GREGA (203 Czech Republic), Ondřej NGO (203 Czech Republic, belonging to the institution), Gabriela VOJTECHOVA (203 Czech Republic), Ondřej MÁJEK (203 Czech Republic, belonging to the institution), Petr URBANEK (203 Czech Republic), Miroslav ZAVORAL (203 Czech Republic) and Stepan SUCHANEK (203 Czech Republic, guarantor)

Edition

Journal of Gastrointestinal and Liver Diseases, CLUJ-NAPOCA, MEDICAL UNIV PRESS, 2021, 1841-8724

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30219 Gastroenterology and hepatology

Country of publisher

Romania

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 2.142

RIV identification code

RIV/00216224:14110/21:00120113

Organization unit

Faculty of Medicine

DOI

UT WoS

000663559800009

Keywords in English

bowel preparation; cleansing agents; colonoscopy; quality of colonoscopy; screening; polyp detection rate

Tags

Tags

International impact, Reviewed
Změněno: 23/7/2021 15:00, Mgr. Tereza Miškechová

Abstract

V originále

Background & Aims: Adequate bowel preparation is essential for successful and effective colonoscopy. Several types of cleansing agents are currently available including low-volume solutions. The aim of this study was to compare the efficacy of four different bowel cleansing agents. Methods: A single-center, prospective, randomized, and single-blind study was performed. Consecutive patients referred for colonoscopy were enrolled and randomized into one of the following types of laxatives: polyethylenglycol 4L (PEG), oral sulfate solution (OSS), 2L polyethylenglycol + ascorbate (2L-PEG/Asc), or magnesium citrate + sodium picosulfate (MCSP). The primary outcome was quality of bowel cleansing evaluated according to the Boston Bowel Preparation Scale (BBPS). Secondary outcomes were polyp detection rate (PDR) and tolerability. Results: Final analysis was performed on 431 patients. The number of patients with adequate bowel preparation (BBPS total scores >= 6 and sub scores >= 2 in each segment) was not significantly different throughout all groups (95.4% PEG; 94.6% OSS; 96.3% 2L-PEG/Asc; 96.2% MCSP; p=0.955). Excellent bowel preparation (BBPS total scores >= 8) was associated with younger age (p=0.007). The groups did not have significantly different PDRs (49.5% PEG; 49.1% OSS; 38% 2L-PEG/Asc; 40.4% MCSP; p=0.201). The strongest predictors of pathology identification were age and male gender. The best-tolerated solution was MCSP (palatability: p<0.001; nausea: p=0.024). Conclusion: All tested laxatives provided comparable efficacy in terms of bowel cleansing quality and PDR. The low-volume agent MCSP was the best tolerated.

Links

NV16-29614A, research and development project
Name: Porovnání účinnosti kolonické kapslové endoskopie a optické kolonoskopie u osob s pozitivním imunochemickým testem na okultní krvácení do stolice
NV17-31909A, research and development project
Name: Vývoj multiparametrického testu nové generace pro predikci rizika rekurence kolorektální neoplázie
NV18-08-00246, research and development project
Name: Endoskopická transmurální resekce versus standardní endoskopická terapie v léčbě kolorektální neoplázie – prospektivní randomizovaná studie
Investor: Ministry of Health of the CR