Comparison of Four Bowel Cleansing Agents for Colonoscopy and
the Factors Affecting their Efficacy. A Prospective, Randomized
Study

J 2021

Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study

KMOCHOVA, Klara, Tomas GREGA, Ondřej NGO, Gabriela VOJTECHOVA, Ondřej MÁJEK et. al.

Basic information

Original name

Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study

Authors

KMOCHOVA, Klara (56 Belgium), Tomas GREGA (203 Czech Republic), Ondřej NGO (203 Czech Republic, belonging to the institution), Gabriela VOJTECHOVA (203 Czech Republic), Ondřej MÁJEK (203 Czech Republic, belonging to the institution), Petr URBANEK (203 Czech Republic), Miroslav ZAVORAL (203 Czech Republic) and Stepan SUCHANEK (203 Czech Republic, guarantor)

Edition

Journal of Gastrointestinal and Liver Diseases, CLUJ-NAPOCA, MEDICAL UNIV PRESS, 2021, 1841-8724

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30219 Gastroenterology and hepatology

Country of publisher

Romania

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.142

RIV identification code

RIV/00216224:14110/21:00120113

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.15403/jgld-3401

UT WoS

000663559800009

Keywords in English

bowel preparation; cleansing agents; colonoscopy; quality of colonoscopy; screening; polyp detection rate

Abstract

V originále

Background & Aims: Adequate bowel preparation is essential for successful and effective colonoscopy. Several types of cleansing agents are currently available including low-volume solutions. The aim of this study was to compare the efficacy of four different bowel cleansing agents. Methods: A single-center, prospective, randomized, and single-blind study was performed. Consecutive patients referred for colonoscopy were enrolled and randomized into one of the following types of laxatives: polyethylenglycol 4L (PEG), oral sulfate solution (OSS), 2L polyethylenglycol + ascorbate (2L-PEG/Asc), or magnesium citrate + sodium picosulfate (MCSP). The primary outcome was quality of bowel cleansing evaluated according to the Boston Bowel Preparation Scale (BBPS). Secondary outcomes were polyp detection rate (PDR) and tolerability. Results: Final analysis was performed on 431 patients. The number of patients with adequate bowel preparation (BBPS total scores >= 6 and sub scores >= 2 in each segment) was not significantly different throughout all groups (95.4% PEG; 94.6% OSS; 96.3% 2L-PEG/Asc; 96.2% MCSP; p=0.955). Excellent bowel preparation (BBPS total scores >= 8) was associated with younger age (p=0.007). The groups did not have significantly different PDRs (49.5% PEG; 49.1% OSS; 38% 2L-PEG/Asc; 40.4% MCSP; p=0.201). The strongest predictors of pathology identification were age and male gender. The best-tolerated solution was MCSP (palatability: p<0.001; nausea: p=0.024). Conclusion: All tested laxatives provided comparable efficacy in terms of bowel cleansing quality and PDR. The low-volume agent MCSP was the best tolerated.

Links

NV16-29614A, research and development project

Name: Porovnání účinnosti kolonické kapslové endoskopie a optické kolonoskopie u osob s pozitivním imunochemickým testem na okultní krvácení do stolice

NV17-31909A, research and development project

Name: Vývoj multiparametrického testu nové generace pro predikci rizika rekurence kolorektální neoplázie

NV18-08-00246, research and development project

Name: Endoskopická transmurální resekce versus standardní endoskopická terapie v léčbě kolorektální neoplázie – prospektivní randomizovaná studie

Investor: Ministry of Health of the CR

Citovat

KMOCHOVA, Klara, Tomas GREGA, Ondřej NGO, Gabriela VOJTECHOVA, Ondřej MÁJEK, Petr URBANEK, Miroslav ZAVORAL and Stepan SUCHANEK. Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study. Journal of Gastrointestinal and Liver Diseases. CLUJ-NAPOCA: MEDICAL UNIV PRESS, 2021, vol. 30, No 2, p. 213-220. ISSN 1841-8724. Available from: https://dx.doi.org/10.15403/jgld-3401.

@article{1783548,
   author = {Kmochova, Klara and Grega, Tomas and Ngo, Ondřej and Vojtechova, Gabriela and Májek, Ondřej and Urbanek, Petr and Zavoral, Miroslav and Suchanek, Stepan},
   article_location = {CLUJ-NAPOCA},
   article_number = {2},
   doi = {http://dx.doi.org/10.15403/jgld-3401},
   keywords = {bowel preparation; cleansing agents; colonoscopy; quality of colonoscopy; screening; polyp detection rate},
   language = {eng},
   issn = {1841-8724},
   journal = {Journal of Gastrointestinal and Liver Diseases},
   title = {Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study},
   url = {https://www.jgld.ro/jgld/index.php/jgld/article/view/3401},
   volume = {30},
   year = {2021}
}

TY  - JOUR
ID  - 1783548
AU  - Kmochova, Klara - Grega, Tomas - Ngo, Ondřej - Vojtechova, Gabriela - Májek, Ondřej - Urbanek, Petr - Zavoral, Miroslav - Suchanek, Stepan
PY  - 2021
TI  - Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study
JF  - Journal of Gastrointestinal and Liver Diseases
VL  - 30
IS  - 2
SP  - 213-220
EP  - 213-220
PB  - MEDICAL UNIV PRESS
SN  - 18418724
KW  - bowel preparation
KW  - cleansing agents
KW  - colonoscopy
KW  - quality of colonoscopy
KW  - screening
KW  - polyp detection rate
UR  - https://www.jgld.ro/jgld/index.php/jgld/article/view/3401
N2  - Background & Aims: Adequate bowel preparation is essential for successful and effective colonoscopy. Several types of cleansing agents are currently available including low-volume solutions. The aim of this study was to compare the efficacy of four different bowel cleansing agents. Methods: A single-center, prospective, randomized, and single-blind study was performed. Consecutive patients referred for colonoscopy were enrolled and randomized into one of the following types of laxatives: polyethylenglycol 4L (PEG), oral sulfate solution (OSS), 2L polyethylenglycol + ascorbate (2L-PEG/Asc), or magnesium citrate + sodium picosulfate (MCSP). The primary outcome was quality of bowel cleansing evaluated according to the Boston Bowel Preparation Scale (BBPS). Secondary outcomes were polyp detection rate (PDR) and tolerability. Results: Final analysis was performed on 431 patients. The number of patients with adequate bowel preparation (BBPS total scores >= 6 and sub scores >= 2 in each segment) was not significantly different throughout all groups (95.4% PEG; 94.6% OSS; 96.3% 2L-PEG/Asc; 96.2% MCSP; p=0.955). Excellent bowel preparation (BBPS total scores >= 8) was associated with younger age (p=0.007). The groups did not have significantly different PDRs (49.5% PEG; 49.1% OSS; 38% 2L-PEG/Asc; 40.4% MCSP; p=0.201). The strongest predictors of pathology identification were age and male gender. The best-tolerated solution was MCSP (palatability: p<0.001; nausea: p=0.024). Conclusion: All tested laxatives provided comparable efficacy in terms of bowel cleansing quality and PDR. The low-volume agent MCSP was the best tolerated.
ER  -

KMOCHOVA, Klara, Tomas GREGA, Ondřej NGO, Gabriela VOJTECHOVA, Ondřej MÁJEK, Petr URBANEK, Miroslav ZAVORAL and Stepan SUCHANEK. Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study. \textit{Journal of Gastrointestinal and Liver Diseases}. CLUJ-NAPOCA: MEDICAL UNIV PRESS, 2021, vol.~30, No~2, p.~213-220. ISSN~1841-8724. Available from: https://dx.doi.org/10.15403/jgld-3401.

Detailed Information on Publication Record