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@article{1783816, author = {Abramyan, John and GeethaandLoganathan, Poongodi and Šulcová, Marie and Buchtová, marcela}, article_location = {Lausanne}, article_number = {June}, doi = {http://dx.doi.org/10.3389/fcell.2021.671475}, keywords = {teeth; dental lamina; apoptosis; odontogenesis; morphogenesis}, language = {eng}, issn = {2296-634X}, journal = {Frontiers in Cell and Developmental Biology}, title = {Role of Cell Death in Cellular Processes During Odontogenesis}, url = {https://doi.org/10.3389/fcell.2021.671475}, volume = {9}, year = {2021} }
TY - JOUR ID - 1783816 AU - Abramyan, John - Geetha-Loganathan, Poongodi - Šulcová, Marie - Buchtová, marcela PY - 2021 TI - Role of Cell Death in Cellular Processes During Odontogenesis JF - Frontiers in Cell and Developmental Biology VL - 9 IS - June SP - "671475" EP - "671475" PB - Frontiers Media S.A. SN - 2296634X KW - teeth KW - dental lamina KW - apoptosis KW - odontogenesis KW - morphogenesis UR - https://doi.org/10.3389/fcell.2021.671475 N2 - The development of a tooth germ in a precise size, shape, and position in the jaw, involves meticulous regulation of cell proliferation and cell death. Apoptosis, as the most common type of programmed cell death during embryonic development, plays a number of key roles during odontogenesis, ranging from the budding of the oral epithelium during tooth initiation, to later tooth germ morphogenesis and removal of enamel knot signaling center. Here, we summarize recent knowledge about the distribution and function of apoptotic cells during odontogenesis in several vertebrate lineages, with a special focus on amniotes (mammals and reptiles). We discuss the regulatory roles that apoptosis plays on various cellular processes during odontogenesis. We also review apoptosis-associated molecular signaling during tooth development, including its relationship with the autophagic pathway. Lastly, we cover apoptotic pathway disruption, and alterations in apoptotic cell distribution in transgenic mouse models. These studies foster a deeper understanding how apoptotic cells affect cellular processes during normal odontogenesis, and how they contribute to dental disorders, which could lead to new avenues of treatment in the future. ER -
ABRAMYAN, John, Poongodi GEETHA-LOGANATHAN, Marie ŠULCOVÁ and marcela BUCHTOVÁ. Role of Cell Death in Cellular Processes During Odontogenesis. \textit{Frontiers in Cell and Developmental Biology}. Lausanne: Frontiers Media S.A., 2021, vol.~9, June, p.~''671475'', 26 pp. ISSN~2296-634X. Available from: https://dx.doi.org/10.3389/fcell.2021.671475.
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