Role of Cell Death in Cellular Processes During Odontogenesis

@article{1783816,
   author = {Abramyan, John and GeethaandLoganathan, Poongodi and Šulcová, Marie and Buchtová, marcela},
   article_location = {Lausanne},
   article_number = {June},
   doi = {http://dx.doi.org/10.3389/fcell.2021.671475},
   keywords = {teeth; dental lamina; apoptosis; odontogenesis; morphogenesis},
   language = {eng},
   issn = {2296-634X},
   journal = {Frontiers in Cell and Developmental Biology},
   title = {Role of Cell Death in Cellular Processes During Odontogenesis},
   url = {https://doi.org/10.3389/fcell.2021.671475},
   volume = {9},
   year = {2021}
}

TY  - JOUR
ID  - 1783816
AU  - Abramyan, John - Geetha-Loganathan, Poongodi - Šulcová, Marie - Buchtová, marcela
PY  - 2021
TI  - Role of Cell Death in Cellular Processes During Odontogenesis
JF  - Frontiers in Cell and Developmental Biology
VL  - 9
IS  - June
SP  - "671475"
EP  - "671475"
PB  - Frontiers Media S.A.
SN  - 2296634X
KW  - teeth
KW  - dental lamina
KW  - apoptosis
KW  - odontogenesis
KW  - morphogenesis
UR  - https://doi.org/10.3389/fcell.2021.671475
N2  - The development of a tooth germ in a precise size, shape, and position in the jaw, involves meticulous regulation of cell proliferation and cell death. Apoptosis, as the most common type of programmed cell death during embryonic development, plays a number of key roles during odontogenesis, ranging from the budding of the oral epithelium during tooth initiation, to later tooth germ morphogenesis and removal of enamel knot signaling center. Here, we summarize recent knowledge about the distribution and function of apoptotic cells during odontogenesis in several vertebrate lineages, with a special focus on amniotes (mammals and reptiles). We discuss the regulatory roles that apoptosis plays on various cellular processes during odontogenesis. We also review apoptosis-associated molecular signaling during tooth development, including its relationship with the autophagic pathway. Lastly, we cover apoptotic pathway disruption, and alterations in apoptotic cell distribution in transgenic mouse models. These studies foster a deeper understanding how apoptotic cells affect cellular processes during normal odontogenesis, and how they contribute to dental disorders, which could lead to new avenues of treatment in the future.
ER  - 

ABRAMYAN, John, Poongodi GEETHA-LOGANATHAN, Marie ŠULCOVÁ and marcela BUCHTOVÁ. Role of Cell Death in Cellular Processes During Odontogenesis. \textit{Frontiers in Cell and Developmental Biology}. Lausanne: Frontiers Media S.A., 2021, vol.~9, June, p.~''671475'', 26 pp. ISSN~2296-634X. Available from: https://dx.doi.org/10.3389/fcell.2021.671475.