Expansion of rDNA and pericentromere satellite repeats in the
genomes of bank voles Myodes glareolus exposed to environmental
radionuclides

J 2021

Expansion of rDNA and pericentromere satellite repeats in the genomes of bank voles Myodes glareolus exposed to environmental radionuclides

JERNFORS, Toni, John DANFORTH, Jenni KESANIEMI, Antom LAVRINIENKO, Eugene TUKALENKO et. al.

Basic information

Original name

Expansion of rDNA and pericentromere satellite repeats in the genomes of bank voles Myodes glareolus exposed to environmental radionuclides

Authors

JERNFORS, Toni (246 Finland), John DANFORTH (124 Canada), Jenni KESANIEMI (246 Finland), Antom LAVRINIENKO (246 Finland), Eugene TUKALENKO (246 Finland), Jiří FAJKUS (203 Czech Republic, belonging to the institution), Martina DVOŘÁČKOVÁ (203 Czech Republic, belonging to the institution), Täppio MAPPES (246 Finland) and Phillip C. WATTS (826 United Kingdom of Great Britain and Northern Ireland)

Edition

Ecology and Evolution, 111 River st, Hoboken 07030-5774, NJ USA, John Wiley & Sons, 2021, 2045-7758

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10618 Ecology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.167

RIV identification code

RIV/00216224:14740/21:00122007

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1002/ece3.7684

UT WoS

000653643300001

Keywords in English

anthropogenic disturbance; chernobyl; copy number; ionizing radiation; myodes glareolus; rDNA

Abstract

V originále

Altered copy number of certain highly repetitive regions of the genome, such as satellite DNA within heterochromatin and ribosomal RNA loci (rDNA), is hypothesized to help safeguard the genome against damage derived from external stressors. We quantified copy number of the 18S rDNA and a pericentromeric satellite DNA (Msat-160) in bank voles (Myodes glareolus) inhabiting the Chernobyl Exclusion Zone (CEZ), an area that is contaminated by radionuclides and where organisms are exposed to elevated levels of ionizing radiation. We found a significant increase in 18S rDNA and Msat-160 content in the genomes of bank voles from contaminated locations within the CEZ compared with animals from uncontaminated locations. Moreover, 18S rDNA and Msat-160 copy number were positively correlated in the genomes of bank voles from uncontaminated, but not in the genomes of animals inhabiting contaminated, areas. These results show the capacity for local-scale geographic variation in genome architecture and are consistent with the genomic safeguard hypothesis. Disruption of cellular processes related to genomic stability appears to be a hallmark effect in bank voles inhabiting areas contaminated by radionuclides.

Links

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

JERNFORS, Toni, John DANFORTH, Jenni KESANIEMI, Antom LAVRINIENKO, Eugene TUKALENKO, Jiří FAJKUS, Martina DVOŘÁČKOVÁ, Täppio MAPPES and Phillip C. WATTS. Expansion of rDNA and pericentromere satellite repeats in the genomes of bank voles Myodes glareolus exposed to environmental radionuclides. Ecology and Evolution. 111 River st, Hoboken 07030-5774, NJ USA: John Wiley & Sons, 2021, vol. 11, No 13, p. 8754-8767. ISSN 2045-7758. Available from: https://dx.doi.org/10.1002/ece3.7684.

@article{1784128,
   author = {Jernfors, Toni and Danforth, John and Kesaniemi, Jenni and Lavrinienko, Antom and Tukalenko, Eugene and Fajkus, Jiří and Dvořáčková, Martina and Mappes, Täppio and Watts, Phillip C.},
   article_location = {111 River st, Hoboken 07030-5774, NJ USA},
   article_number = {13},
   doi = {http://dx.doi.org/10.1002/ece3.7684},
   keywords = {anthropogenic disturbance; chernobyl; copy number; ionizing radiation; myodes glareolus; rDNA},
   language = {eng},
   issn = {2045-7758},
   journal = {Ecology and Evolution},
   title = {Expansion of rDNA and pericentromere satellite repeats in the genomes of bank voles Myodes glareolus exposed to environmental radionuclides},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/ece3.7684},
   volume = {11},
   year = {2021}
}

TY  - JOUR
ID  - 1784128
AU  - Jernfors, Toni - Danforth, John - Kesaniemi, Jenni - Lavrinienko, Antom - Tukalenko, Eugene - Fajkus, Jiří - Dvořáčková, Martina - Mappes, Täppio - Watts, Phillip C.
PY  - 2021
TI  - Expansion of rDNA and pericentromere satellite repeats in the genomes of bank voles Myodes glareolus exposed to environmental radionuclides
JF  - Ecology and Evolution
VL  - 11
IS  - 13
SP  - 8754-8767
EP  - 8754-8767
PB  - John Wiley & Sons
SN  - 20457758
KW  - anthropogenic disturbance
KW  - chernobyl
KW  - copy number
KW  - ionizing radiation
KW  - myodes glareolus
KW  - rDNA
UR  - https://onlinelibrary.wiley.com/doi/10.1002/ece3.7684
N2  - Altered copy number of certain highly repetitive regions of the genome, such as satellite DNA within heterochromatin and ribosomal RNA loci (rDNA), is hypothesized to help safeguard the genome against damage derived from external stressors. We quantified copy number of the 18S rDNA and a pericentromeric satellite DNA (Msat-160) in bank voles (Myodes glareolus) inhabiting the Chernobyl Exclusion Zone (CEZ), an area that is contaminated by radionuclides and where organisms are exposed to elevated levels of ionizing radiation. We found a significant increase in 18S rDNA and Msat-160 content in the genomes of bank voles from contaminated locations within the CEZ compared with animals from uncontaminated locations. Moreover, 18S rDNA and Msat-160 copy number were positively correlated in the genomes of bank voles from uncontaminated, but not in the genomes of animals inhabiting contaminated, areas. These results show the capacity for local-scale geographic variation in genome architecture and are consistent with the genomic safeguard hypothesis. Disruption of cellular processes related to genomic stability appears to be a hallmark effect in bank voles inhabiting areas contaminated by radionuclides.
ER  -

JERNFORS, Toni, John DANFORTH, Jenni KESANIEMI, Antom LAVRINIENKO, Eugene TUKALENKO, Jiří FAJKUS, Martina DVOŘÁČKOVÁ, Täppio MAPPES and Phillip C. WATTS. Expansion of rDNA and pericentromere satellite repeats in the genomes of bank voles Myodes glareolus exposed to environmental radionuclides. \textit{Ecology and Evolution}. 111 River st, Hoboken 07030-5774, NJ USA: John Wiley \&{} Sons, 2021, vol.~11, No~13, p.~8754-8767. ISSN~2045-7758. Available from: https://dx.doi.org/10.1002/ece3.7684.

Detailed Information on Publication Record