Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer

VINKLEROVÁ, Petra, Markéta BEDNAŘÍKOVÁ, Luboš MINÁŘ, Michal FELSINGER, Jitka HAUSNEROVÁ, Petra OVESNÁ and Vít WEINBERGER. Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer. Healthcare. Basel: MDPI, 2021, vol. 9, No 7, p. 1-9. ISSN 2227-9032. Available from: https://dx.doi.org/10.3390/healthcare9070902.

Basic information

• Original name: Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer
• Authors: VINKLEROVÁ, Petra (203 Czech Republic, belonging to the institution), Markéta BEDNAŘÍKOVÁ (203 Czech Republic, belonging to the institution), Luboš MINÁŘ (203 Czech Republic, belonging to the institution), Michal FELSINGER (203 Czech Republic, belonging to the institution), Jitka HAUSNEROVÁ (203 Czech Republic, belonging to the institution), Petra OVESNÁ (203 Czech Republic, belonging to the institution) and Vít WEINBERGER (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Healthcare, Basel, MDPI, 2021, 2227-9032.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30214 Obstetrics and gynaecology
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.160
• RIV identification code: RIV/00216224:14110/21:00122021
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.3390/healthcare9070902
• UT WoS: 000677363300001
• Keywords in English: endometrial cancer; tumor markers; ER; PR; p53; L1CAM
• Tags: 14110212, 14110230, 14110411, 14119612, rivok
• Tags: International impact, Reviewed

Abstract

Endometrial cancer is the most common gynecologic malignancy in Europe and usually diagnosed in its initial stage owing to early symptoms of abnormal bleeding. There is no population screening for this disease, although it can sometimes be accidentally diagnosed in asymptomatic patients. Our study aims to determine differences in clinical and tumor characteristics between an asymptomatic and symptomatic group of patients. This unicentric prospective observational study took place in University Hospital Brno between January 2016 and December 2019. A total of 264 patients met inclusion criteria (26% asymptomatic, 74% with reported symptoms). We did not find a statistically significant difference in clinical characteristics (menopausal status, parity, age, BMI, and serum level of CA 125) between groups. According to ultrasound examination, bleeding tumors were larger (19.5 vs. 12.7 mm, p <= 0.001). Definitive histology results indicated more frequent lymphovascular space invasion (p < 0.001), along with deep myometrial (p = 0.001) and cervical (p = 0.002) invasion. There was no difference in advanced stages of the tumor. We did not substantiate statistically significant difference in immunohistochemical profile (estrogen and progesterone receptors, L1 cell adhesion molecule, tumor protein p53), which is relevant for tumor recurrence risk and survival capacity. Our conclusions affirmed that bleeding occurs more often among patients with local tumor invasion into the myometrium and cervical stroma. Final International Federation of Gynecology and Obstetrics (FIGO) stage, histology, and immunohistochemical characteristics do not significantly affect symptom appearance.