The benefit of the diffusion kurtosis imaging in presurgical
evaluation in patients with focal MR-negative epilepsy

J 2021

The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy

BARTOŇOVÁ, Michaela, Marek BARTOŇ, Pavel ŘÍHA, Lubomír VOJTÍŠEK, Milan BRÁZDIL et. al.

Basic information

Original name

The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy

Authors

BARTOŇOVÁ, Michaela (703 Slovakia, belonging to the institution), Marek BARTOŇ (203 Czech Republic, belonging to the institution), Pavel ŘÍHA (203 Czech Republic, belonging to the institution), Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

Scientific Reports, London, NATURE RESEARCH, 2021, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.996

RIV identification code

RIV/00216224:14740/21:00120114

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1038/s41598-021-92804-w

UT WoS

000674488400010

Keywords in English

TEMPORAL-LOBE EPILEPSY; WHITE-MATTER ABNORMALITIES; CORTICAL DYSPLASIA; PROPOSAL; LESIONS; IMAGES; MODEL

Abstract

V originále

Y The effectivity of diffusion-weighted MRI methods in detecting the epileptogenic zone (EZ) was tested. Patients with refractory epilepsy (N=25) who subsequently underwent resective surgery were recruited. First, the extent of white matter (WM) asymmetry from mean kurtosis (MK) was calculated in order to detect the lobe with the strongest impairment. Second, a newly developed metric was used, reflecting a selection of brain areas with concurrently increased mean Diffusivity, reduced fractional Anisotropy, and reduced mean Kurtosis (iDrArK). A two-step EZ detection was performed as (1) lobe-specific detection, (2) iDrArK voxel-wise detection (with a possible lobe-specific restriction if the result of the first step was significant in a given subject). The method results were compared with the surgery resection zones. From the whole cohort (N=25), the numbers of patients with significant results were: 10 patients in lobe detection and 9 patients in EZ detection. From these subsets of patients with significant results, the impaired lobe was successfully detected with 100% accuracy; the EZ was successfully detected with 89% accuracy. The detection of the EZ using iDrArK was substantially more successful when compared with solo diffusional parameters (or their pairwise combinations). For a subgroup with significant results from step one (N=10), iDrArK without lobe restriction achieved 37.5% accuracy; lobe-restricted iDrArK achieved 100% accuracy. The study shows the plausibility of MK for detecting widespread WM changes and the benefit of combining different diffusional voxel-wise parameters.

Links

NU21-04-00254, research and development project

Name: Detekce zóny počátku záchvatu u multi-lezionální epilepsie s užitím multimodálního neurozobrazování (Acronym: MultiEPI)

Investor: Ministry of Health of the CR, Detection of seizure onset zone in multi-lesional epilepsies using multimodal imaging methods, Subprogram 1 - standard

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

BARTOŇOVÁ, Michaela, Marek BARTOŇ, Pavel ŘÍHA, Lubomír VOJTÍŠEK, Milan BRÁZDIL and Ivan REKTOR. The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy. Scientific Reports. London: NATURE RESEARCH, 2021, vol. 11, No 1, p. "14208", 10 pp. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-021-92804-w.

@article{1785382,
   author = {Bartoňová, Michaela and Bartoň, Marek and Říha, Pavel and Vojtíšek, Lubomír and Brázdil, Milan and Rektor, Ivan},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-021-92804-w},
   keywords = {TEMPORAL-LOBE EPILEPSY; WHITE-MATTER ABNORMALITIES; CORTICAL DYSPLASIA; PROPOSAL; LESIONS; IMAGES; MODEL},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy},
   url = {https://www.nature.com/articles/s41598-021-92804-w.pdf},
   volume = {11},
   year = {2021}
}

TY  - JOUR
ID  - 1785382
AU  - Bartoňová, Michaela - Bartoň, Marek - Říha, Pavel - Vojtíšek, Lubomír - Brázdil, Milan - Rektor, Ivan
PY  - 2021
TI  - The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy
JF  - Scientific Reports
VL  - 11
IS  - 1
SP  - "14208"
EP  - "14208"
PB  - NATURE RESEARCH
SN  - 20452322
KW  - TEMPORAL-LOBE EPILEPSY
KW  - WHITE-MATTER ABNORMALITIES
KW  - CORTICAL DYSPLASIA
KW  - PROPOSAL
KW  - LESIONS
KW  - IMAGES
KW  - MODEL
UR  - https://www.nature.com/articles/s41598-021-92804-w.pdf
N2  - Y The effectivity of diffusion-weighted MRI methods in detecting the epileptogenic zone (EZ) was tested. Patients with refractory epilepsy (N=25) who subsequently underwent resective surgery were recruited. First, the extent of white matter (WM) asymmetry from mean kurtosis (MK) was calculated in order to detect the lobe with the strongest impairment. Second, a newly developed metric was used, reflecting a selection of brain areas with concurrently increased mean Diffusivity, reduced fractional Anisotropy, and reduced mean Kurtosis (iDrArK). A two-step EZ detection was performed as (1) lobe-specific detection, (2) iDrArK voxel-wise detection (with a possible lobe-specific restriction if the result of the first step was significant in a given subject). The method results were compared with the surgery resection zones. From the whole cohort (N=25), the numbers of patients with significant results were: 10 patients in lobe detection and 9 patients in EZ detection. From these subsets of patients with significant results, the impaired lobe was successfully detected with 100% accuracy; the EZ was successfully detected with 89% accuracy. The detection of the EZ using iDrArK was substantially more successful when compared with solo diffusional parameters (or their pairwise combinations). For a subgroup with significant results from step one (N=10), iDrArK without lobe restriction achieved 37.5% accuracy; lobe-restricted iDrArK achieved 100% accuracy. The study shows the plausibility of MK for detecting widespread WM changes and the benefit of combining different diffusional voxel-wise parameters.
ER  -

BARTOŇOVÁ, Michaela, Marek BARTOŇ, Pavel ŘÍHA, Lubomír VOJTÍŠEK, Milan BRÁZDIL and Ivan REKTOR. The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy. \textit{Scientific Reports}. London: NATURE RESEARCH, 2021, vol.~11, No~1, p.~''14208'', 10 pp. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-021-92804-w.

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