The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy

BARTOŇOVÁ, Michaela, Marek BARTOŇ, Pavel ŘÍHA, Lubomír VOJTÍŠEK, Milan BRÁZDIL and Ivan REKTOR. The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy. Scientific Reports. London: NATURE RESEARCH, vol. 11, No 1, p. "14208", 10 pp. ISSN 2045-2322. doi:10.1038/s41598-021-92804-w. 2021.

Basic information

• Original name: The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy
• Authors: BARTOŇOVÁ, Michaela (703 Slovakia, belonging to the institution), Marek BARTOŇ (203 Czech Republic, belonging to the institution), Pavel ŘÍHA (203 Czech Republic, belonging to the institution), Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Scientific Reports, London, NATURE RESEARCH, 2021, 2045-2322.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30103 Neurosciences
• Country of publisher: Germany
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.996
• RIV identification code: RIV/00216224:14740/21:00120114
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1038/s41598-021-92804-w
• UT WoS: 000674488400010
• Keywords in English: TEMPORAL-LOBE EPILEPSY; WHITE-MATTER ABNORMALITIES; CORTICAL DYSPLASIA; PROPOSAL; LESIONS; IMAGES; MODEL
• Tags: 14110127, CF MAFIL, podil, rivok
• Tags: International impact, Reviewed

Abstract

Y The effectivity of diffusion-weighted MRI methods in detecting the epileptogenic zone (EZ) was tested. Patients with refractory epilepsy (N=25) who subsequently underwent resective surgery were recruited. First, the extent of white matter (WM) asymmetry from mean kurtosis (MK) was calculated in order to detect the lobe with the strongest impairment. Second, a newly developed metric was used, reflecting a selection of brain areas with concurrently increased mean Diffusivity, reduced fractional Anisotropy, and reduced mean Kurtosis (iDrArK). A two-step EZ detection was performed as (1) lobe-specific detection, (2) iDrArK voxel-wise detection (with a possible lobe-specific restriction if the result of the first step was significant in a given subject). The method results were compared with the surgery resection zones. From the whole cohort (N=25), the numbers of patients with significant results were: 10 patients in lobe detection and 9 patients in EZ detection. From these subsets of patients with significant results, the impaired lobe was successfully detected with 100% accuracy; the EZ was successfully detected with 89% accuracy. The detection of the EZ using iDrArK was substantially more successful when compared with solo diffusional parameters (or their pairwise combinations). For a subgroup with significant results from step one (N=10), iDrArK without lobe restriction achieved 37.5% accuracy; lobe-restricted iDrArK achieved 100% accuracy. The study shows the plausibility of MK for detecting widespread WM changes and the benefit of combining different diffusional voxel-wise parameters.

Links

• LM2018129, research and development project: Name: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministry of Education, Youth and Sports of the CR

• NU21-04-00254, research and development project: Name: Detekce zóny počátku záchvatu u multi-lezionální epilepsie s užitím multimodálního neurozobrazování (Acronym: MultiEPI)

Investor: Ministry of Health of the CR, Detection of seizure onset zone in multi-lesional epilepsies using multimodal imaging methods, Subprogram 1 - standard