Extracellular volume quantification using synthetic haematocrit
assessed from native and post-contrast longitudinal relaxation
T1 times of a blood pool

J 2021

Extracellular volume quantification using synthetic haematocrit assessed from native and post-contrast longitudinal relaxation T1 times of a blood pool

OPATŘIL, Lukáš, Roman PANOVSKÝ, Jan MÁCHAL, Tomas HOLECEK, Lucia MASÁROVÁ et. al.

Basic information

Original name

Extracellular volume quantification using synthetic haematocrit assessed from native and post-contrast longitudinal relaxation T1 times of a blood pool

Authors

OPATŘIL, Lukáš (203 Czech Republic, belonging to the institution), Roman PANOVSKÝ (203 Czech Republic, guarantor, belonging to the institution), Jan MÁCHAL (203 Czech Republic, belonging to the institution), Tomas HOLECEK (203 Czech Republic), Lucia MASÁROVÁ (703 Slovakia, belonging to the institution), Vera FEITOVA (203 Czech Republic), Vladimír KINCL (203 Czech Republic, belonging to the institution), Marek HODĚJOVSKÝ (203 Czech Republic, belonging to the institution) and Lenka ŠPINAROVÁ (203 Czech Republic, belonging to the institution)

Edition

BMC Cardiovascular Disorders, London, BMC, 2021, 1471-2261

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.174

RIV identification code

RIV/00216224:14110/21:00122063

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1186/s12872-021-02179-z

UT WoS

000679726500001

Keywords in English

Extracellular volume; ECV; Synthetic haematocrit; Cardiovascular magnetic resonance; CMR

Abstract

V originále

Background In terms of cardiovascular magnetic resonance are haematocrit values required for calculation of extracellular volume fraction (ECV). Previously published studies have hypothesized that haematocrit could be calculated from T1 blood pool relaxation time, however only native T1 relaxation time values have been used and the resulting formulae had been both in reciprocal and linear proportion. The aim of the study was to generate a synthetic haematocrit formula from only native relaxation time values first, calculate whether linear or reciprocal model is more precise in haematocrit estimation and then determine whether adding post-contrast values further improve its precision. Methods One hundred thirty-nine subjects underwent CMR examination. Haematocrit was measured using standard laboratory methods. Afterwards T1 relaxation times before and after the application of a contrast agent were measured and a statistical relationship between these values was calculated. Results Different linear and reciprocal models were created to estimate the value of synthetic haematocrit and ECV. The highest coefficient of determination was observed in the combined reciprocal model “− 0.047 + (779/ blood native) − (11.36/ blood post-contrast)”. Conclusions This study provides more evidence that assessing synthetic haematocrit and synthetic ECV is feasible and statistically most accurate model to use is reciprocal. Adding post-contrast values to the calculation was proved to improve the precision of the formula statistically significantly.

Links

MUNI/A/1685/2020, interní kód MU

Name: Nové trendy v diagnostice a terapii kardiomyopatií

Investor: Masaryk University

Citovat

OPATŘIL, Lukáš, Roman PANOVSKÝ, Jan MÁCHAL, Tomas HOLECEK, Lucia MASÁROVÁ, Vera FEITOVA, Vladimír KINCL, Marek HODĚJOVSKÝ and Lenka ŠPINAROVÁ. Extracellular volume quantification using synthetic haematocrit assessed from native and post-contrast longitudinal relaxation T1 times of a blood pool. BMC Cardiovascular Disorders. London: BMC, 2021, vol. 21, No 1, p. 1-8. ISSN 1471-2261. Available from: https://dx.doi.org/10.1186/s12872-021-02179-z.

@article{1785583,
   author = {Opatřil, Lukáš and Panovský, Roman and Máchal, Jan and Holecek, Tomas and Masárová, Lucia and Feitova, Vera and Kincl, Vladimír and Hodějovský, Marek and Špinarová, Lenka},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s12872-021-02179-z},
   keywords = {Extracellular volume; ECV; Synthetic haematocrit; Cardiovascular magnetic resonance; CMR},
   language = {eng},
   issn = {1471-2261},
   journal = {BMC Cardiovascular Disorders},
   title = {Extracellular volume quantification using synthetic haematocrit assessed from native and post-contrast longitudinal relaxation T1 times of a blood pool},
   url = {https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-021-02179-z},
   volume = {21},
   year = {2021}
}

TY  - JOUR
ID  - 1785583
AU  - Opatřil, Lukáš - Panovský, Roman - Máchal, Jan - Holecek, Tomas - Masárová, Lucia - Feitova, Vera - Kincl, Vladimír - Hodějovský, Marek - Špinarová, Lenka
PY  - 2021
TI  - Extracellular volume quantification using synthetic haematocrit assessed from native and post-contrast longitudinal relaxation T1 times of a blood pool
JF  - BMC Cardiovascular Disorders
VL  - 21
IS  - 1
SP  - 1-8
EP  - 1-8
PB  - BMC
SN  - 14712261
KW  - Extracellular volume
KW  - ECV
KW  - Synthetic haematocrit
KW  - Cardiovascular magnetic resonance
KW  - CMR
UR  - https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-021-02179-z
N2  - Background In terms of cardiovascular magnetic resonance are haematocrit values required for calculation of extracellular volume fraction (ECV). Previously published studies have hypothesized that haematocrit could be calculated from T1 blood pool relaxation time, however only native T1 relaxation time values have been used and the resulting formulae had been both in reciprocal and linear proportion. The aim of the study was to generate a synthetic haematocrit formula from only native relaxation time values first, calculate whether linear or reciprocal model is more precise in haematocrit estimation and then determine whether adding post-contrast values further improve its precision. Methods One hundred thirty-nine subjects underwent CMR examination. Haematocrit was measured using standard laboratory methods. Afterwards T1 relaxation times before and after the application of a contrast agent were measured and a statistical relationship between these values was calculated. Results Different linear and reciprocal models were created to estimate the value of synthetic haematocrit and ECV. The highest coefficient of determination was observed in the combined reciprocal model “− 0.047 + (779/ blood native) − (11.36/ blood post-contrast)”. Conclusions This study provides more evidence that assessing synthetic haematocrit and synthetic ECV is feasible and statistically most accurate model to use is reciprocal. Adding post-contrast values to the calculation was proved to improve the precision of the formula statistically significantly.
ER  -

OPATŘIL, Lukáš, Roman PANOVSKÝ, Jan MÁCHAL, Tomas HOLECEK, Lucia MASÁROVÁ, Vera FEITOVA, Vladimír KINCL, Marek HODĚJOVSKÝ and Lenka ŠPINAROVÁ. Extracellular volume quantification using synthetic haematocrit assessed from native and post-contrast longitudinal relaxation T1 times of a blood pool. \textit{BMC Cardiovascular Disorders}. London: BMC, 2021, vol.~21, No~1, p.~1-8. ISSN~1471-2261. Available from: https://dx.doi.org/10.1186/s12872-021-02179-z.

Detailed Information on Publication Record