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@article{1785584,
author = {Klugar, Miloslav and Riad, Abanoub and Mekhemar, Mohamed and Conrad, Jonas and Buchbender, Mayte and Howaldt, HansandPeter and Attia, Sameh},
article_location = {Basel},
article_number = {8},
doi = {http://dx.doi.org/10.3390/biology10080752},
keywords = {adverse effects; BTN162 vaccine; ChAdOx1 COVID-19 vaccine; cross-sectional studies; COVID-19 vaccines; drug-related side effects and adverse reactions; Germany; health personnel; mRNA-1273 vaccine; prevalence},
language = {eng},
issn = {2079-7737},
journal = {Biology},
title = {Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers},
url = {https://www.mdpi.com/2079-7737/10/8/752},
volume = {10},
year = {2021}
}
TY - JOUR
ID - 1785584
AU - Klugar, Miloslav - Riad, Abanoub - Mekhemar, Mohamed - Conrad, Jonas - Buchbender, Mayte - Howaldt, Hans-Peter - Attia, Sameh
PY - 2021
TI - Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers
JF - Biology
VL - 10
IS - 8
SP - 1-21
EP - 1-21
PB - MDPI
SN - 20797737
KW - adverse effects
KW - BTN162 vaccine
KW - ChAdOx1 COVID-19 vaccine
KW - cross-sectional studies
KW - COVID-19 vaccines
KW - drug-related side effects and adverse reactions
KW - Germany
KW - health personnel
KW - mRNA-1273 vaccine
KW - prevalence
UR - https://www.mdpi.com/2079-7737/10/8/752
N2 - Background: the increasing number of COVID-19 vaccines available to the public may trigger hesitancy or selectivity towards vaccination. This study aimed to evaluate the post-vaccination side effects of the different vaccines approved in Germany; Methods: a cross-sectional survey-based study was carried out using an online questionnaire validated and tested for a priori reliability. The questionnaire inquired about demographic data, medical and COVID-19-related anamneses, and local, systemic, oral, and skin-related side effects following COVID-19 vaccination; Results: out of the 599 participating healthcare workers, 72.3% were females, and 79.1% received mRNA-based vaccines, while 20.9% received a viral vector-based vaccine. 88.1% of the participants reported at least one side effect. Injection site pain (75.6%) was the most common local side effect, and headache/fatigue (53.6%), muscle pain (33.2%), malaise (25%), chills (23%), and joint pain (21.2%) were the most common systemic side effects. The vast majority (84.9%) of side effects resolved within 1–3 days post-vaccination; Conclusions: the mRNA-based vaccines were associated with a higher prevalence of local side effects (78.3% vs. 70.4%; Sig. = 0.064), while the viral vector-based vaccine was associated with a higher prevalence of systemic side effects (87.2% vs. 61%; Sig. < 0.001). Females and the younger age group were associated with an increased risk of side effects either after mRNA-based or viral vector-based vaccines. The gender- and age-based differences warrant further rigorous investigation and standardized methodology.
ER -
KLUGAR, Miloslav, Abanoub RIAD, Mohamed MEKHEMAR, Jonas CONRAD, Mayte BUCHBENDER, Hans-Peter HOWALDT and Sameh ATTIA. Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers. \textit{Biology}. Basel: MDPI, 2021, vol.~10, No~8, p.~1-21. ISSN~2079-7737. Available from: https://dx.doi.org/10.3390/biology10080752.
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