| DYKOVÁ, Iva, J. ŽÁK, Martin REICHARD, Kamila SOUČKOVÁ, Ondřej SLABÝ and Radim BLAŽEK. Swim bladder as a primary site of mycobacterial infection in Nothobranchius 'belly sliders'. Diseases of aquatic organisms. Inter Research, 2021, vol. 145, July, p. 111-117. ISSN 0177-5103. Available from: https://dx.doi.org/10.3354/dao03601. |
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@article{1785687,
author = {Dyková, Iva and Žák, J. and Reichard, Martin and Součková, Kamila and Slabý, Ondřej and Blažek, Radim},
article_number = {July},
doi = {http://dx.doi.org/10.3354/dao03601},
keywords = {Abnormal swimming; Laboratory-reared killifish; Model organism; Mycobacterial infection},
language = {eng},
issn = {0177-5103},
journal = {Diseases of aquatic organisms},
title = {Swim bladder as a primary site of mycobacterial infection in Nothobranchius 'belly sliders'},
url = {https://doi.org/10.3354/dao03601},
volume = {145},
year = {2021}
}
TY - JOUR
ID - 1785687
AU - Dyková, Iva - Žák, J. - Reichard, Martin - Součková, Kamila - Slabý, Ondřej - Blažek, Radim
PY - 2021
TI - Swim bladder as a primary site of mycobacterial infection in Nothobranchius 'belly sliders'
JF - Diseases of aquatic organisms
VL - 145
IS - July
SP - 111-117
EP - 111-117
PB - Inter Research
SN - 01775103
KW - Abnormal swimming
KW - Laboratory-reared killifish
KW - Model organism
KW - Mycobacterial infection
UR - https://doi.org/10.3354/dao03601
N2 - The swim bladder inflates early after fish hatching via its interconnection with the digestive tract (ductus pneumaticus). This interconnection may serve as a portal to foreign particles, including bacteria, causing deficiencies in primary swim bladder inflation. We histologically examined 134 African annual killifish (genus Nothobranchius) with secondary loss of swim bladder function ('belly sliders'). We demonstrate that these fish lost the ability of air regulation in their swim bladders likely due to Mycobacterium spp. infection at an individual-specific age. Nearly all examined belly sliders had thickened swim bladder walls, and their swim bladder was filled with material containing mycobacteria, cell debris, young monocytic cells and phagocyting macrophages. Mycobacterial infection was restricted to the swim bladder in juveniles, where mycobacteria likely enter the host through the ductus pneumaticus. Infection in adults was systemic and mycobacteria were present in all examined organs. Presence of mycobacteria in the epithelial lining and submucosal layers of the digestive tract of adults suggests that it may also serve as the entrance site of infection. We suspect 2 sources of Mycobacterium contamination: dietary (with bloodworms) and/or contaminated hatching substrate. These sources of contamination may be eliminated by use of laboratory dry feed and egg disinfection prior to hatching.
ER -
DYKOVÁ, Iva, J. ŽÁK, Martin REICHARD, Kamila SOUČKOVÁ, Ondřej SLABÝ and Radim BLAŽEK. Swim bladder as a primary site of mycobacterial infection in Nothobranchius 'belly sliders'. \textit{Diseases of aquatic organisms}. Inter Research, 2021, vol.~145, July, p.~111-117. ISSN~0177-5103. Available from: https://dx.doi.org/10.3354/dao03601.
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