Structural correlates of trauma-induced hyperarousal in mice

J 2021

Structural correlates of trauma-induced hyperarousal in mice

RUAT, Julia, Daniel E. HEINZ, Florian P. BINDER, Tibor ŠTARK, Robert NEUNER et. al.

Basic information

Original name

Structural correlates of trauma-induced hyperarousal in mice

Authors

RUAT, Julia, Daniel E. HEINZ, Florian P. BINDER, Tibor ŠTARK (703 Slovakia, belonging to the institution), Robert NEUNER, Alice HARTMANN, Paul M. KAPLICK, Alon CHEN, Michael CZISCH and Carsten T. WOTJAK (guarantor)

Edition

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2021, 0278-5846

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.201

RIV identification code

RIV/00216224:14110/21:00122080

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.pnpbp.2021.110404

UT WoS

000685538900013

Keywords in English

Post-traumatic stress disorder; Hyperarousal; Magnetic resonance imaging; Grey matter volume; Animal model

Abstract

V originále

Post-traumatic stress disorder (PTSD) is a chronic disease caused by traumatic incidents. Numerous studies have revealed grey matter volume differences in affected individuals. The nature of the disease renders it difficult to distinguish between a priori versus a posteriori changes. To overcome this difficulty, we studied the consequences of a traumatic event on brain morphology in mice before and 4 weeks after exposure to brief foot shocks (or sham treatment), and correlated morphology with symptoms of hyperarousal. In the latter context, we assessed hyperarousal upon confrontation with acoustic, visual, or composite (acoustic/visual/tactile) threats and integrated the individual readouts into a single Hyperarousal Score using logistic regression analysis. MRI scans with subsequent whole-brain deformation-based morphometry (DBM) analysis revealed a volume decrease of the dorsal hippocampus and an increase of the reticular nucleus in shocked mice when compared to non-shocked controls. Using the Hyperarousal Score as regressor for the post-exposure MRI measurement, we observed negative correlations with several brain structures including the dorsal hippocampus. If the development of changes with respect to the basal MRI was considered, reduction in globus pallidus volume reflected hyperarousal severity. Our findings demonstrate that a brief traumatic incident can cause volume changes in defined brain structures and suggest the globus pallidus as an important hub for the control of fear responses to threatening stimuli of different sensory modalities.

Links

MUNI/A/1249/2020, interní kód MU

Name: Základní výzkum v oblasti farmakokinetiky, neurobiologie závislostí a aplikovaný výzkum v oblasti personalizované farmakoterapie v onkologii (Acronym: SV_Farmakologie2021)

Investor: Masaryk University

Citovat

RUAT, Julia, Daniel E. HEINZ, Florian P. BINDER, Tibor ŠTARK, Robert NEUNER, Alice HARTMANN, Paul M. KAPLICK, Alon CHEN, Michael CZISCH and Carsten T. WOTJAK. Structural correlates of trauma-induced hyperarousal in mice. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2021, vol. 111, December 2021, p. 1-10. ISSN 0278-5846. Available from: https://dx.doi.org/10.1016/j.pnpbp.2021.110404.

@article{1785860,
   author = {Ruat, Julia and Heinz, Daniel E. and Binder, Florian P. and Štark, Tibor and Neuner, Robert and Hartmann, Alice and Kaplick, Paul M. and Chen, Alon and Czisch, Michael and Wotjak, Carsten T.},
   article_location = {OXFORD},
   article_number = {December 2021},
   doi = {http://dx.doi.org/10.1016/j.pnpbp.2021.110404},
   keywords = {Post-traumatic stress disorder; Hyperarousal; Magnetic resonance imaging; Grey matter volume; Animal model},
   language = {eng},
   issn = {0278-5846},
   journal = {PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY},
   title = {Structural correlates of trauma-induced hyperarousal in mice},
   url = {https://www.sciencedirect.com/science/article/pii/S0278584621001639?via%3Dihub},
   volume = {111},
   year = {2021}
}

TY  - JOUR
ID  - 1785860
AU  - Ruat, Julia - Heinz, Daniel E. - Binder, Florian P. - Štark, Tibor - Neuner, Robert - Hartmann, Alice - Kaplick, Paul M. - Chen, Alon - Czisch, Michael - Wotjak, Carsten T.
PY  - 2021
TI  - Structural correlates of trauma-induced hyperarousal in mice
JF  - PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
VL  - 111
IS  - December 2021
SP  - 1-10
EP  - 1-10
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 02785846
KW  - Post-traumatic stress disorder
KW  - Hyperarousal
KW  - Magnetic resonance imaging
KW  - Grey matter volume
KW  - Animal model
UR  - https://www.sciencedirect.com/science/article/pii/S0278584621001639?via%3Dihub
N2  - Post-traumatic stress disorder (PTSD) is a chronic disease caused by traumatic incidents. Numerous studies have revealed grey matter volume differences in affected individuals. The nature of the disease renders it difficult to distinguish between a priori versus a posteriori changes. To overcome this difficulty, we studied the consequences of a traumatic event on brain morphology in mice before and 4 weeks after exposure to brief foot shocks (or sham treatment), and correlated morphology with symptoms of hyperarousal. In the latter context, we assessed hyperarousal upon confrontation with acoustic, visual, or composite (acoustic/visual/tactile) threats and integrated the individual readouts into a single Hyperarousal Score using logistic regression analysis. MRI scans with subsequent whole-brain deformation-based morphometry (DBM) analysis revealed a volume decrease of the dorsal hippocampus and an increase of the reticular nucleus in shocked mice when compared to non-shocked controls. Using the Hyperarousal Score as regressor for the post-exposure MRI measurement, we observed negative correlations with several brain structures including the dorsal hippocampus. If the development of changes with respect to the basal MRI was considered, reduction in globus pallidus volume reflected hyperarousal severity. Our findings demonstrate that a brief traumatic incident can cause volume changes in defined brain structures and suggest the globus pallidus as an important hub for the control of fear responses to threatening stimuli of different sensory modalities.
ER  -

RUAT, Julia, Daniel E. HEINZ, Florian P. BINDER, Tibor ŠTARK, Robert NEUNER, Alice HARTMANN, Paul M. KAPLICK, Alon CHEN, Michael CZISCH and Carsten T. WOTJAK. Structural correlates of trauma-induced hyperarousal in mice. \textit{PROGRESS IN NEURO-PSYCHOPHARMACOLOGY \&{} BIOLOGICAL PSYCHIATRY}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2021, vol.~111, December 2021, p.~1-10. ISSN~0278-5846. Available from: https://dx.doi.org/10.1016/j.pnpbp.2021.110404.

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