A model of perinatal stress and childhood wheezing: ELSPAC-CZ cohort

ŠTĚPANÍKOVÁ, Irena, Vojtěch THON, Ondřej MIKEŠ and Jana KLÁNOVÁ. A model of perinatal stress and childhood wheezing: ELSPAC-CZ cohort. Pediatric Pulmonology. Hoboken: Wiley, 2021, vol. 56, No 6, p. 1471-1483. ISSN 8755-6863. Available from: https://dx.doi.org/10.1002/ppul.25346.

Basic information

• Original name: A model of perinatal stress and childhood wheezing: ELSPAC-CZ cohort
• Authors: ŠTĚPANÍKOVÁ, Irena (203 Czech Republic, guarantor, belonging to the institution), Vojtěch THON (203 Czech Republic, belonging to the institution), Ondřej MIKEŠ (203 Czech Republic, belonging to the institution) and Jana KLÁNOVÁ (203 Czech Republic, belonging to the institution).
• Edition: Pediatric Pulmonology, Hoboken, Wiley, 2021, 8755-6863.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30209 Paediatrics
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.090
• RIV identification code: RIV/00216224:14310/21:00122092
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.1002/ppul.25346
• UT WoS: 000628916000001
• Keywords in English: child wheezing; early life stress; maternal depression; resiratory infections
• Tags: rivok
• Tags: International impact, Reviewed

Abstract

Background Prenatal origins of wheezing are not fully understood. This study develops a model of mechanisms linking perinatal stress exposure to wheeze phenotypes in children. Methods Data were obtained from 1880 mother-child dyads participating in ELSPAC-CZ birth cohort. Wheeze phenotypes assessed between birth and age 7 years included "never wheeze," "early-onset transient (EOT) wheeze," "early-onset persistent (EOP) wheeze," and "late-onset (LO) wheeze." Prenatal and postnatal stress exposures were assessed in mid-pregnancy and 6 months after delivery, respectively, using an inventory of 42 life events. Results In adjusted models, children in the highest tercile (high) versus lowest tercile (low) for prenatal life events had a 38% higher risk of EOT wheeze (relative risk ratio [RRR] = 1.38; 95% confidence interval [CI] = 1.01-1.88; p = .041) and 50% higher risk of LO wheeze (RRR = 1.50; 95% CI = 1.00-2.25; p = .047). High versus low exposure to postnatal life events predicted a 60% increase in relative risk of EOT wheeze (RRR = 1.60; 95% CI = 1.17-2.19; p = .003) and medium versus low exposure was related to an 85% increase in relative risk of EOP wheeze (RRR = 1.85; 95% CI = 1.16-2.95; p = .010). Lower respiratory tract infections and postpartum depression partially mediated between postnatal life events and any wheeze (indirect effects 1.06, 95% CI = 1.02-1.09, p = .003 and odds ratio [OR] = 1.08, 95% CI = 1.02-1.15, p = .012, respectively), while postnatal events mediate for prenatal events (indirect effect OR = 1.11; 95% CI = 1.03-1.18; p = .005). Conclusions Exposures to prenatal and postnatal life events are risk factors for the development of wheezing. Prenatal stress contributes to wheeze directly and also through postnatal life events, respiratory infections, and maternal depression.

Links

• EF15_003/0000469, research and development project: Name: Cetocoen Plus
• EF16_013/0001761, research and development project: Name: RECETOX RI
• EF17_043/0009632, research and development project: Name: CETOCOEN Excellence
• LM2018121, research and development project: Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

• 857560, interní kód MU(CEP code: EF17_043/0009632): Name: CETOCOEN Excellence (Acronym: CETOCOEN Excellence)

Investor: European Union, Spreading excellence and widening participation