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@article{1786144, author = {Štěpaníková, Irena and Thon, Vojtěch and Mikeš, Ondřej and Klánová, Jana}, article_location = {Hoboken}, article_number = {6}, doi = {http://dx.doi.org/10.1002/ppul.25346}, keywords = {child wheezing; early life stress; maternal depression; resiratory infections}, language = {eng}, issn = {8755-6863}, journal = {Pediatric Pulmonology}, title = {A model of perinatal stress and childhood wheezing: ELSPAC-CZ cohort}, url = {https://onlinelibrary.wiley.com/doi/10.1002/ppul.25346}, volume = {56}, year = {2021} }
TY - JOUR ID - 1786144 AU - Štěpaníková, Irena - Thon, Vojtěch - Mikeš, Ondřej - Klánová, Jana PY - 2021 TI - A model of perinatal stress and childhood wheezing: ELSPAC-CZ cohort JF - Pediatric Pulmonology VL - 56 IS - 6 SP - 1471-1483 EP - 1471-1483 PB - Wiley SN - 87556863 KW - child wheezing KW - early life stress KW - maternal depression KW - resiratory infections UR - https://onlinelibrary.wiley.com/doi/10.1002/ppul.25346 N2 - Background Prenatal origins of wheezing are not fully understood. This study develops a model of mechanisms linking perinatal stress exposure to wheeze phenotypes in children. Methods Data were obtained from 1880 mother-child dyads participating in ELSPAC-CZ birth cohort. Wheeze phenotypes assessed between birth and age 7 years included "never wheeze," "early-onset transient (EOT) wheeze," "early-onset persistent (EOP) wheeze," and "late-onset (LO) wheeze." Prenatal and postnatal stress exposures were assessed in mid-pregnancy and 6 months after delivery, respectively, using an inventory of 42 life events. Results In adjusted models, children in the highest tercile (high) versus lowest tercile (low) for prenatal life events had a 38% higher risk of EOT wheeze (relative risk ratio [RRR] = 1.38; 95% confidence interval [CI] = 1.01-1.88; p = .041) and 50% higher risk of LO wheeze (RRR = 1.50; 95% CI = 1.00-2.25; p = .047). High versus low exposure to postnatal life events predicted a 60% increase in relative risk of EOT wheeze (RRR = 1.60; 95% CI = 1.17-2.19; p = .003) and medium versus low exposure was related to an 85% increase in relative risk of EOP wheeze (RRR = 1.85; 95% CI = 1.16-2.95; p = .010). Lower respiratory tract infections and postpartum depression partially mediated between postnatal life events and any wheeze (indirect effects 1.06, 95% CI = 1.02-1.09, p = .003 and odds ratio [OR] = 1.08, 95% CI = 1.02-1.15, p = .012, respectively), while postnatal events mediate for prenatal events (indirect effect OR = 1.11; 95% CI = 1.03-1.18; p = .005). Conclusions Exposures to prenatal and postnatal life events are risk factors for the development of wheezing. Prenatal stress contributes to wheeze directly and also through postnatal life events, respiratory infections, and maternal depression. ER -
ŠTĚPANÍKOVÁ, Irena, Vojtěch THON, Ondřej MIKEŠ and Jana KLÁNOVÁ. A model of perinatal stress and childhood wheezing: ELSPAC-CZ cohort. \textit{Pediatric Pulmonology}. Hoboken: Wiley, 2021, vol.~56, No~6, p.~1471-1483. ISSN~8755-6863. Available from: https://dx.doi.org/10.1002/ppul.25346.
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