J 2021

A model of perinatal stress and childhood wheezing: ELSPAC-CZ cohort

ŠTĚPANÍKOVÁ, Irena, Vojtěch THON, Ondřej MIKEŠ and Jana KLÁNOVÁ

Basic information

Original name

A model of perinatal stress and childhood wheezing: ELSPAC-CZ cohort

Authors

ŠTĚPANÍKOVÁ, Irena (203 Czech Republic, guarantor, belonging to the institution), Vojtěch THON (203 Czech Republic, belonging to the institution), Ondřej MIKEŠ (203 Czech Republic, belonging to the institution) and Jana KLÁNOVÁ (203 Czech Republic, belonging to the institution)

Edition

Pediatric Pulmonology, Hoboken, Wiley, 2021, 8755-6863

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30209 Paediatrics

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.090

RIV identification code

RIV/00216224:14310/21:00122092

Organization unit

Faculty of Science

DOI

UT WoS

000628916000001

Keywords in English

child wheezing; early life stress; maternal depression; resiratory infections

Tags

Tags

International impact, Reviewed
Změněno: 16/5/2022 11:34, Mgr. Marie Šípková, DiS.

Abstract

V originále

Background Prenatal origins of wheezing are not fully understood. This study develops a model of mechanisms linking perinatal stress exposure to wheeze phenotypes in children. Methods Data were obtained from 1880 mother-child dyads participating in ELSPAC-CZ birth cohort. Wheeze phenotypes assessed between birth and age 7 years included "never wheeze," "early-onset transient (EOT) wheeze," "early-onset persistent (EOP) wheeze," and "late-onset (LO) wheeze." Prenatal and postnatal stress exposures were assessed in mid-pregnancy and 6 months after delivery, respectively, using an inventory of 42 life events. Results In adjusted models, children in the highest tercile (high) versus lowest tercile (low) for prenatal life events had a 38% higher risk of EOT wheeze (relative risk ratio [RRR] = 1.38; 95% confidence interval [CI] = 1.01-1.88; p = .041) and 50% higher risk of LO wheeze (RRR = 1.50; 95% CI = 1.00-2.25; p = .047). High versus low exposure to postnatal life events predicted a 60% increase in relative risk of EOT wheeze (RRR = 1.60; 95% CI = 1.17-2.19; p = .003) and medium versus low exposure was related to an 85% increase in relative risk of EOP wheeze (RRR = 1.85; 95% CI = 1.16-2.95; p = .010). Lower respiratory tract infections and postpartum depression partially mediated between postnatal life events and any wheeze (indirect effects 1.06, 95% CI = 1.02-1.09, p = .003 and odds ratio [OR] = 1.08, 95% CI = 1.02-1.15, p = .012, respectively), while postnatal events mediate for prenatal events (indirect effect OR = 1.11; 95% CI = 1.03-1.18; p = .005). Conclusions Exposures to prenatal and postnatal life events are risk factors for the development of wheezing. Prenatal stress contributes to wheeze directly and also through postnatal life events, respiratory infections, and maternal depression.

Links

EF15_003/0000469, research and development project
Name: Cetocoen Plus
EF16_013/0001761, research and development project
Name: RECETOX RI
EF17_043/0009632, research and development project
Name: CETOCOEN Excellence
LM2018121, research and development project
Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI
857560, interní kód MU
(CEP code: EF17_043/0009632)
Name: CETOCOEN Excellence (Acronym: CETOCOEN Excellence)
Investor: European Union, Spreading excellence and widening participation